Dermatology and Oxidative Stress

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: closed (22 March 2024) | Viewed by 3220

Special Issue Editors


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Guest Editor
Department of Microbiology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Interests: oxidative stress; inflammation; chronic inflammatory skin diseases

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Guest Editor
Department of Microbiology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Interests: oxidative stress; skin infections; autoimmune diseases; chronic inflammatory skin diseases

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Guest Editor
1. Department of Dermatology, “Victor Babes” Clinical Hospital for Infectious Diseases, 030303 Bucharest, Romania
2. Department of Dermatology, “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania
Interests: dermatology; inflammation; carcinogenesis; oxidative stress
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Dermatology, “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania
2. Department of Dermatology, “Victor Babes” Clinical Hospital for Infectious Diseases, 283 Mihai Bravu Street, 030303 Bucharest, Romania
Interests: dermatology; psoriasis; skin infections; skin cancers; viral infections; autoimmune disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidative stress has recently been recognized as playing a pivotal role in the pathogenesis of various disorders such as cardiovascular diseases, neurodegenerative disorders, viral infections, and skin diseases. In the human body, reactive oxygen species (ROS) have a dual role, as they participate in the defense against pathogens and in maintaining cell homeostasis, but at the same time, when they accumulate in high concentrations, they may exert harmful effects on the host cells, leading to various tissue injuries. 

On the skin, ROS induce the appearance of erythema, edema, or pain and play a major role in the aging process. There is an intense debate around whether oxidative stress initiates pathogenic processes that result in skin diseases or is a consequence of the activity of inflammatory cells involved in disease pathogenesis. Numerous studies attest to the link between inflammation and oxidative stress. The relationship between inflammation and oxidative stress is bidirectional because inflammatory cells release ROS, but ROS in turn can activate pathways involved in chronic inflammation. In this context, studies increasingly suggest that oxidative stress plays a crucial role in the pathogenesis of numerous inflammatory/autoimmune skin diseases such as alopecia areata, vitiligo, lichen planus, psoriasis, etc. It should also be noted that ROS have a genotoxic effect, and prolonged exposure to ROS in the context of chronic inflammation can lead to malignancy. 

Investigating the effects of the imbalance between prooxidants and antioxidants on cell signaling pathways, cell differentiation, and apoptosis could yield valuable insights into the mechanisms underlying many diseases.

The aim of this Special Issue is to explore recent advances in research involving the role of oxidative stress in the pathogenesis of skin diseases, new markers of oxidative stress for the diagnosis and monitoring of skin diseases, antioxidant therapies, and the link between oxidative stress and skin carcinogenesis. We welcome researchers to submit original research manuscripts and reviews to provide readers with a better understanding of the relationship between oxidative stress and skin diseases.

Dr. Cristina Iulia Mitran
Dr. Madalina Irina Mitran
Dr. Mircea Tampa
Prof. Dr. Simona Roxana Georgescu
Guest Editors

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Keywords

  • markers of oxidative stress
  • ROS-mediated cellular signaling
  • chronic inflammation
  • skin carcinogenesis
  • skin aging
  • skin infections
  • autoimmunity
  • antioxidant therapies

Published Papers (1 paper)

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Review

15 pages, 311 KiB  
Review
Markers of Oxidative Stress in Patients with Acne: A Literature Review
by Gabriela Loredana Popa, Cristina Iulia Mitran, Madalina Irina Mitran, Mircea Tampa, Clara Matei, Mircea Ioan Popa and Simona Roxana Georgescu
Life 2023, 13(7), 1433; https://doi.org/10.3390/life13071433 - 23 Jun 2023
Cited by 4 | Viewed by 2287
Abstract
Acne vulgaris is a chronic inflammatory skin disease of the pilosebaceous unit. Its pathogenesis is multifactorial and involves the overlap between four main processes: alteration of the keratinization, increased sebum production, colonization with Cutibacterium acnes, and inflammation. The role of oxidative stress [...] Read more.
Acne vulgaris is a chronic inflammatory skin disease of the pilosebaceous unit. Its pathogenesis is multifactorial and involves the overlap between four main processes: alteration of the keratinization, increased sebum production, colonization with Cutibacterium acnes, and inflammation. The role of oxidative stress (OS) has been intensively studied in inflammatory skin conditions such as psoriasis, vitiligo, or atopic dermatitis. However, the involvement of OS in the pathogenesis of acne is less known. The evidence accumulated over the last decade suggests that in the case of acne patients, there is an imbalance between oxidants and antioxidants. In this review, we analyzed studies that evaluated markers of OS in patients with acne, published in the last ten years, with the aim of providing new insights into the pathogenesis of acne. Full article
(This article belongs to the Special Issue Dermatology and Oxidative Stress)
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