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Life
Special Issues
The Emerging Role of Probiotics in Disease
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The Emerging Role of Probiotics in Disease

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 3709

Special Issue Editors

Dr. Michele D'Angelo

E-Mail Website
Guest Editor
Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L'Aquila, Italy
Interests: neurodegerative disorders; Parkinson’s disease; probiotics; brain repair
Special Issues, Collections and Topics in MDPI journals
Dr. Vanessa Castelli

E-Mail Website1 Website2
Guest Editor
Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L'Aquila, Italy
Interests: brain repair; neurological disorder; Parkinson’s disease; probiotics; neuropathic pain; stem cells
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Different nutraceutical interventions have been devoted to improving biological outcomes in different conditions, including the use of probiotics. Probiotics have shown potential effects in a variety of human disorders, including metabolic, autoimmune, cancer, and neurological disorders. Probiotics have shown strong immunoregulatory activity; thus, probiotics and their products can trigger regulatory pathways and T cells, reducing the inflammatory condition. In addition, it has been reported that probiotics can alter the microbiota composition, affecting the gut–brain axis function—a bidirectional system between the central nervous system and the enteric nervous system. Indeed, the use of probiotics has shown its potential in neurological disorders prevention or treatment or as adjuvant therapy. Furthermore, substantial improvements have been made in probiotic research, including the development of novel delivery methods and mechanism-based probiotics, new probiotic formulations, and other advances.

This Special Issue aims to collect all the research highlighting the new insights into probiotics in human disease. Both reviews and original research articles reporting our progress and current understanding in this field are welcome.

Dr. Michele D'Angelo
Dr. Vanessa Castelli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • probiotics
  • drug delivery
  • cancer
  • inflammation
  • autoimmune disorders
  • gut–brain axis
  • neurological disorders
  • new probiotic formulations

Published Papers (1 paper)

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Research

20 pages, 3406 KiB  
Article
Protective Effects of Probiotics on Cognitive and Motor Functions, Anxiety Level, Visceral Sensitivity, Oxidative Stress and Microbiota in Mice with Antibiotic-Induced Dysbiosis
by Alisa Arslanova, Aksiniya Tarasova, Anastasia Alexandrova, Vera Novoselova, Ilnar Shaidullov, Dilyara Khusnutdinova, Tatiana Grigoryeva, Dina Yarullina, Olga Yakovleva and Guzel Sitdikova
Life 2021, 11(8), 764; https://doi.org/10.3390/life11080764 - 29 Jul 2021
Cited by 13 | Viewed by 3143
Abstract
Accumulating clinical and preclinical data indicate a prominent role of gut microbiota in regulation of physiological functions. The gut-brain axis imbalance due to gut dysbiosis is associated with a range of neurodegenerative diseases. Probiotics were suggested not only to restore intestinal dysbiosis but [...] Read more.
Accumulating clinical and preclinical data indicate a prominent role of gut microbiota in regulation of physiological functions. The gut-brain axis imbalance due to gut dysbiosis is associated with a range of neurodegenerative diseases. Probiotics were suggested not only to restore intestinal dysbiosis but also modulate stress response and improve mood and anxiety symptoms. In this study, we assessed the effects of probiotic lactobacilli on behavioral reactions, the level of oxidative stress and microbiota content in mice administered to broad-spectrum antibiotics. Our study demonstrates that antibiotic treatment of adolescent mice for two weeks resulted in higher mortality and lower weight gain and induced significant changes in behavior including lower locomotor and exploratory activity, reduced muscle strength, visceral hypersensitivity, higher level of anxiety and impaired cognitive functions compared to the control group. These changes were accompanied by decreased diversity and total amount of bacteria, abundance of Proteobacteria and Verrucomicrobia phyla, and reduced Firmicutes/Bacteroides ratio in the gut microbiota. Moreover, a higher level of oxidative stress was found in brain and skeletal muscle tissues of mice treated with antibiotics. Oral administration of two Lactobacillus strains prevented the observed changes and improved not only microbiota content but also the behavioral alterations, suggesting a neuroprotective and antioxidant role of probiotics. Full article
(This article belongs to the Special Issue The Emerging Role of Probiotics in Disease)
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