Neuronal Cell Rearrangement during Aging and Neurodegenerative Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 4134
Special Issue Editors
Interests: neurodegeneration; neurodegenerative disorders; neuronal cell rearrangement; Parkinson; PPARs
Special Issues, Collections and Topics in MDPI journals
Interests: neurodegenerative diseases; neurodegeneration; neurological disorders; Parkinson’s disease; probiotics; neuropathic pain; stem cells
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Brain cells normally react adaptively to bioenergetic alterations and oxidative stress, which result from constant activity in the neuronal circuits. During aging and in neurodegenerative diseases, these mechanisms are altered. Neuronal cells have distinctive age-related variations in their metabolism and function, and thus, a greater predisposition to insults and disease. During aging, neuron metabolism may be modified, causing glucose hypometabolism, decreased transport of the critical substrates that underlie metabolism, changes in calcium signaling, and mitochondrial dysfunction. In addition, there is an accumulation of impaired and aggregated proteins in the cytoplasm and in the mitochondria, mainly due to oxidative stress and neuroinflammation. These alterations lead to greater neuron vulnerability in various regions of the brain and increased susceptibility to several diseases. The aim of this Special Issue is to collect studies or review articles on the main neuronal cell rearrangements that occur during aging or in neurodegenerative diseases, as well as studies on therapeutic approaches to counteracting these compromised mechanisms.
Dr. Michele D'Angelo
Dr. Vanessa Castelli
Guest Editors
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