Imaging in Neurosurgery: State of the Art

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (10 September 2022) | Viewed by 3139

Special Issue Editors

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Guest Editor
Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, 67100 L’Aquila, Italy
Interests: neuroradiology; MRI; focused ultrasound; tremor; spine imaging
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Division of Brain Sciences, Imperial College London, London SW7 2BX, UK
Interests: neuroradiology; neurodegenerative and movement disorders; focused ultrasound (FUS); essential tremor; Parkinson’s disease
Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
Interests: functional MRI; surgical planning; functional brain mapping; brain connectivity; diffusion MRI; brain tumor

Special Issue Information

Dear Colleagues,

Neuroimaging plays a fundamental and essential role in the neurosurgical treatment of most brain and spine pathologies. The preoperative study of brain tumors is certainly a milestone in the application of presurgical neuroimaging; structural and functional imaging using advanced MRI sequences (such as perfusion imaging, functional MRI (fMRI), and diffusion MRI (dMRI) sequences) provide fundamental information for the selection of surgical candidates, the tailoring of individualized surgical planning based on structural and functional organization of the brain, and the prediction of postoperative functional outcome. Emerging radiomics techniques will also be implemented in the near future to increase the diagnostic and prognostic validity of neuroimaging data.

Accurate anatomical targeting through neuroimaging techniques is also crucial for optimal clinical outcomes in functional neurosurgical ablation and stimulation procedures such as DBS.

Imaging guidance indeed represents the basis of numerous growing minimally invasive neurosurgical treatments, such as the MRgFUS, used predominantly for the treatment of tremor and chronic pain, but with interesting perspectives in the treatment of epilepsy, psychiatric disorders, drug delivery and brain tumors.

Neuroimaging also plays a central and ever-expanding role in image-guided neurosurgery, thanks to the technological development of scanners and the advent of fusion imaging (MR-CT, MR-US), with a broad range of applications in brain and spine surgery.

This Special Issue aims to present the latest advances in the cross-disciplinary field of neuroimaging in neurosurgery, to build a focused update from different points of view. We welcome contributions from all specialists involved in the diagnosis and treatment of neurosurgical diseases, from basic neurological sciences (neuroanatomy, neurobiology) to medical clinical specialties (neurology, neurosurgery, neuroradiology, neurophysiology).

Dr. Federico Bruno
Dr. Ayesha Jameel
Dr. Yanmei Tie
Guest Editors

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  • neurosurgery
  • neuroimaging
  • MRI
  • radiomics
  • brain tumors
  • functional neurosurgery
  • surgical planning
  • functional brain mapping
  • image-guided neurosurgery

Published Papers (1 paper)

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13 pages, 6581 KiB  
Diffusion Tensor Imaging of a Median Nerve by Magnetic Resonance: A Pilot Study
by Kanza Awais, Žiga Snoj, Erika Cvetko and Igor Serša
Life 2022, 12(5), 748; - 18 May 2022
Cited by 2 | Viewed by 1999
The magnetic resonance Diffusion Tensor Imaging (DTI) is a powerful extension of Diffusion Weighted Imaging (DWI) utilizing multiple bipolar gradients, allowing for the evaluation of the microstructural environment of the highly anisotropic tissues. DTI was predominantly used for the assessment of the central [...] Read more.
The magnetic resonance Diffusion Tensor Imaging (DTI) is a powerful extension of Diffusion Weighted Imaging (DWI) utilizing multiple bipolar gradients, allowing for the evaluation of the microstructural environment of the highly anisotropic tissues. DTI was predominantly used for the assessment of the central nervous system (CNS), but with the advancement in magnetic resonance (MR) hardware and software, it has now become possible to image the peripheral nerves which were difficult to evaluate previously because of their small caliber. This study focuses on the assessment of the human median peripheral nerve ex vivo by DTI microscopy at 9.4 T magnetic field which allowed the evaluation of diffusion eigenvalues, the mean diffusivity and the fractional anisotropy at 35 μm in-plane resolution. The resolution was sufficient for clear depiction of all nerve anatomical structures and therefore further image analysis allowed the obtaining of average values for DT parameters in nerve fascicles (intrafascicular region and perineurium) as well as in the surrounding epineurium. The results confirmed the highest fractional anisotropy of 0.33 and principal diffusion eigenvalue of 1.0 × 10−9 m2/s in the intrafascicular region, somewhat lower values of 0.27 and 0.95 × 10−9 m2/s in the perineurium region and close to isotropic with very slow diffusion (0.15 and 0.05 × 10−9 m2/s) in the epineurium region. Full article
(This article belongs to the Special Issue Imaging in Neurosurgery: State of the Art)
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