Biomarkers and Prognostic Markers in Cardiovascular Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Medical Research".

Deadline for manuscript submissions: 20 March 2025 | Viewed by 759

Special Issue Editors


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Guest Editor
1. Department of Cardiac Surgery Research, Lankenau Institute for Medical Research, Main Line Health, Wynnewood, PA 19096, USA
2. Department of Cardiac Surgery, Lankenau Heart Institute, Main Line Health, Wynnewood, PA 19096, USA
Interests: cardiac surgery; arrhythmias; clinical cardiology; electrophysiology

Special Issue Information

Dear Colleagues,

Cardiovascular disease represents a pandemic that is a leading cause of severe morbidity and mortality for adults worldwide, while reducing patients’ quality of life and imposing a significant financial burden on societies. Although the development of more efficient treatment approaches remains the central goal of modern research, identifying novel biomarkers and prognostic markers to enable earlier diagnosis and more targeted intervention is also critical. In this rapidly changing landscape, we call on all cardiac surgeons, cardiologists, and allied researchers to contribute to this Special Issue and share their own experiences on biomarkers and prognostic markers for cardiovascular disease. Our vision is to provide the best currently available and up-to-date evidence on this important topic, thus providing all the necessary information for a smooth translation of basic research into clinical practice.

Yours faithfully,

Dr. Dimitrios E. Magouliotis
Dr. Serge Sicouri
Guest Editors

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Keywords

  • biomarkers
  • cardiovascular disease
  • prognostic markers
  • prognostic tools
  • cardiac disease
  • aortic disease

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Published Papers (1 paper)

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Research

11 pages, 1812 KiB  
Article
Hemostatic Properties of Aortic Root Preservation versus Root Replacement for Acute Type A Aortic Dissection: A Pooled Analysis
by Dimitrios E. Magouliotis, Arian Arjomandi Rad, Alessandro Viviano, Aung Ye Oo, Andrew Xanthopoulos, Serge Sicouri, Basel Ramlawi and Thanos Athanasiou
Life 2024, 14(10), 1255; https://doi.org/10.3390/life14101255 - 1 Oct 2024
Abstract
Objective: We reviewed the available literature on patients undergoing aortic repair for acute type A aortic dissection (ATAAD) with either aortic root preservation (RP) or root replacement (RR). Methods: Original research studies that evaluated short- and mid-term hemostatic properties of RP versus RR [...] Read more.
Objective: We reviewed the available literature on patients undergoing aortic repair for acute type A aortic dissection (ATAAD) with either aortic root preservation (RP) or root replacement (RR). Methods: Original research studies that evaluated short- and mid-term hemostatic properties of RP versus RR groups were identified, from 2000 to 2024. Intraoperative transfusions of red blood cells (RBCs), reoperation for bleeding, strategy of hemostatic sealing of the anastomosis in root repair following the reapproximation of the dissected layers of the aortic wall (with/without biological glue), and operative mortality were the primary endpoints. Postoperative morbidity and overall and reoperation-free survival at one and five years were the secondary endpoints. A sensitivity analysis was performed using the leave-one-out method. Results: Ten studies were included in the qualitative and quantitative synthesis, incorporating data from 6850 patients (RP: 4389 patients; RR: 2461 patients). Root preservation demonstrated a lower median transfusion of RBCs (WMD: −1.00; 95% CI: −1.41, −0.59; p < 0.01) and incidence of reoperation for bleeding compared to root replacement (OR: 0.67; 95% CI: 0.58, 0.77; p < 0.01). The majority of studies did not use biological glue in root repair to avoid the risk of an anastomotic pseudoaneurysm. No difference was found regarding postoperative morbidity, along with mid-term overall and reoperation-free survival. Conclusions: Root preservation without the use of biological glue during aortic repair is associated with enhanced hemostatic traits compared to the root replacement approach. A future well-designed Randomized Controlled Trial should further validate our outcomes. Full article
(This article belongs to the Special Issue Biomarkers and Prognostic Markers in Cardiovascular Diseases)
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