Liver and Infection
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: closed (16 November 2022) | Viewed by 16709
Special Issue Editors
Interests: chronic viral hepatitis; NAFLD; sepsis; immune response; infectious diseases
Special Issue Information
Dear Colleagues,
This Special Issue will focus on infections in patients with liver diseases, including pathogenesis, immunology, clinical presentation, etiology, diagnosis, and treatment. The liver, with its ability to produce acute phase proteins, complement proteins and cytokines, plays a central role in regulating inflammation. A balanced pro- and anti-inflammatory liver response results in pathogen clearance and resolution of inflammation. Liver dysfunction during sepsis in patients without pre-existing liver disease is an independent predictor of mortality. The risk of developing bacterial infections is further enhanced in patients with liver cirrhosis, making them ten times more susceptible to bloodstream infections and resulting in a fourfold increase in mortality. Furthermore, the epidemiology and etiology of bacteriemia in liver cirrhosis patients is currently changing.
While survival following liver transplantation has dramatically increased owing to an improvement in surgical techniques and immunosuppression, infectious complications are a major source of morbidity and mortality in liver transplant recipients.
While non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in Western countries, the impact of NAFLD on bacterial infections has only recently started to be explored. Patients with NAFLD have been described to have more common recurrent bacterial infections, urinary tract infections, bacteriemia of gastrointestinal origin, Clostridioides difficile enterocolitis, and more severe pneumonia. Recently, COVID-19 has highlighted the importance of NAFLD in outcomes of severe viral infections. There is growing evidence that immunological changes in patients with NAFLD might have a profound impact in the course of infectious diseases—a place where we have not been looking so far. The rapidly increasing prevalence of NAFLD requires novel therapeutic and prophylactic approaches based on better understanding of the immunopathogenesis of infections in these patients.
The aim of this interdisciplinary issue is to bring together experts from different fields in promoting this important topic.
Dr. William Nseir
Dr. Neven Papic
Guest Editors
Manuscript Submission Information
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Keywords
- liver diseases
- non-alcoholic fatty liver disease
- liver cirrhosis
- liver transplantation
- infections
- sepsis
- COVID-19