Eye Manifestations of Systemic Disease, 2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 1131

Special Issue Editor


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Guest Editor
Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA
Interests: age related macular degeneration; diabetic retinopathy; ocular trauma; retinal detachments; hereditary retinal and macular diseases
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Special Issue Information

Dear Colleagues,

As an extension of the brain, the eye is a sensory organ unlike any other, with a uniqueness which comes from the fact that its neurological structures can be directly visualized on clinical examination. Systemic pathological changes such as infections, malignancies, and inflammatory disorders may be reflected in the eye; as such, the ophthalmologist is often the first to diagnose them. In this Special Issue, we explore the eye as it relates to the body as a whole. We consider how systemic diseases such as diabetes can lead to both reversible and irreversible vision loss, and how the eye is an immunologically privileged organ that can still be affected by systemic infectious diseases and autoimmune disorders, leading to ocular inflammation. We also explore how ophthalmic signs and symptoms, as well as the cellular and vascular structures in the retina, can be diagnostic sources for neurological conditions such as multiple sclerosis, myasthenia gravis, and Alzheimer’s disease. Additionally, we review the latest advances in ocular imaging and its significance and impact on the diagnosis and management of ophthalmic disorders. Finally, we discuss recent advances in ophthalmic surgery for the treatment and prevention of blindness. Our goal in this Special Issue is to provide a comprehensive perspective of the eye and overview how the visual system interacts with the body during various states of disease.

Dr. Manju Subramanian
Guest Editor

Manuscript Submission Information

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Keywords

  • age-related macular
  • degeneration diabetic retinopathy
  • ocular trauma
  • retinal detachments
  • hereditary retinal and macular diseases

Published Papers (1 paper)

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Review

12 pages, 4736 KiB  
Review
Ocular Manifestation in Systemic Sclerosis—A Literature Review
by Katarzyna Paczwa, Magdalena Rerych, Katarzyna Romanowska-Próchnicka, Radosław Różycki and Joanna Gołębiewska
Life 2024, 14(5), 627; https://doi.org/10.3390/life14050627 - 13 May 2024
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Abstract
Systemic sclerosis (SSc) is a chronic autoimmune connective tissue disease that affects more than 2 million people worldwide. It manifests through vasculopathy, an abnormal immunological response, and fibrosis leading to dysfunction of the multiple organs. The disease is categorized into two subtypes: limited [...] Read more.
Systemic sclerosis (SSc) is a chronic autoimmune connective tissue disease that affects more than 2 million people worldwide. It manifests through vasculopathy, an abnormal immunological response, and fibrosis leading to dysfunction of the multiple organs. The disease is categorized into two subtypes: limited cutaneous SSc and diffuse cutaneous SSc. Scleroderma can affect vital organs with respiratory, cardiac, renal, ocular, and dermatological complications. The ocular manifestations of the disease can occur in the anterior and posterior segments of the eye. Changes in the anterior segment related to the disease include eyelid skin remodeling, dry eye syndrome, and conjunctival abnormalities. The disease’s impact on the posterior segment of the eye mostly causes pathologies in the retinal microcirculatory system and abnormalities in the optic nerve. This review provides detailed insights into ocular complications associated with scleroderma. Full article
(This article belongs to the Special Issue Eye Manifestations of Systemic Disease, 2nd Edition)
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