New Updates in Adipocytes and Adipose Tissue: 2nd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 948

Special Issue Editors


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Guest Editor
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Interests: brown adipose tissue; thermogenesis; beige adipocytes; irisin; autophagy; adipokines; interleukin-6
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Interests: proteomics; metabolomics; serum metabolites; obesity; insulin resistance; system biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The first edition of this Special Issue was a great success. Now, we invite you to publish in the second edition. (https://www.mdpi.com/journal/life/special_issues/Adipo_Life)

Obesity is one of the major risk factors of insulin resistance, metabolic syndrome, coronary heart disease, and cancer, which are all leading causes of mortality today. Although the combined prevalence of overweight and obesity has increased continuously up to 40–50% in most developed countries, effective therapeutic approaches, including behavioral therapy, pharmacotherapy, or bariatric surgery, against this threat are very limited. Adipose tissue is a complex organ with profound effects on the homeostasis of the entire body. White adipocytes function as long-term energy storage by accumulating a single large lipid vacuole, which is surrounded by a thin rim of cytoplasm that contains only small amounts of mitochondria. They also produce metabolites and signaling lipids and secrete protein factors (adipokines). Brown and beige adipocytes accumulate numerous small lipid droplets in a multilocular arrangement, contain a large amount of mitochondria-rich cytoplasm, and convert glucose and fatty acids into heat. The production of adipocyte-derived factors changes under different nutritional and pathological conditions that contribute to the pathophysiology of several comorbidities. This Special Issue focuses on metabolic changes and novel molecular pathways observed in obesity with a high emphasis on adipose tissues that can be targeted in the fight against obesity and metabolic syndrome.

Dr. Kristóf Endre Károly
Dr. Éva Csősz
Guest Editors

Manuscript Submission Information

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Keywords

  • adipose tissue
  • obesity
  • inflammation
  • thermogenesis
  • adipokines
  • insulin resistance

Published Papers (1 paper)

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Review

28 pages, 2061 KiB  
Review
The Interplay between Obesity and Inflammation
by Ilinca Savulescu-Fiedler, Razvan Mihalcea, Serban Dragosloveanu, Cristian Scheau, Radu Octavian Baz, Ana Caruntu, Andreea-Elena Scheau, Constantin Caruntu and Serban Nicolae Benea
Life 2024, 14(7), 856; https://doi.org/10.3390/life14070856 - 8 Jul 2024
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Abstract
Obesity is an important condition affecting the quality of life of numerous patients and increasing their associated risk for multiple diseases, including tumors and immune-mediated disorders. Inflammation appears to play a major role in the development of obesity and represents a central point [...] Read more.
Obesity is an important condition affecting the quality of life of numerous patients and increasing their associated risk for multiple diseases, including tumors and immune-mediated disorders. Inflammation appears to play a major role in the development of obesity and represents a central point for the activity of cellular and humoral components in the adipose tissue. Macrophages play a key role as the main cellular component of the adipose tissue regulating the chronic inflammation and modulating the secretion and differentiation of various pro- and anti-inflammatory cytokines. Inflammation also involves a series of signaling pathways that might represent the focus for new therapies and interventions. Weight loss is essential in decreasing cardiometabolic risks and the degree of associated inflammation; however, the latter can persist for long after the excess weight is lost, and can involve changes in macrophage phenotypes that can ensure the metabolic adjustment. A clear understanding of the pathophysiological processes in the adipose tissue and the interplay between obesity and chronic inflammation can lead to a better understanding of the development of comorbidities and may ensure future targets for the treatment of obesity. Full article
(This article belongs to the Special Issue New Updates in Adipocytes and Adipose Tissue: 2nd Edition)
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