New Updates in Adipocytes and Adipose Tissue—3rd Edition

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 634

Special Issue Editors


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Guest Editor
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Interests: brown adipose tissue; thermogenesis; beige adipocytes; irisin; autophagy; adipokines; interleukin-6
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Interests: proteomics; metabolomics; serum metabolites; obesity; insulin resistance; system biology
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
Interests: adipocytes; thermogenesis; obesity; diabetes; SLC transporter; nutrition; bone

Special Issue Information

Dear Colleagues,

The first and second editions of this Special Issue were a great success. Now, we invite you to participate in the third edition. (https://www.mdpi.com/journal/life/special_issues/Adipo_Lifehttps://www.mdpi.com/journal/life/special_issues/BDQ1HTRE87)

Obesity is one of the major risk factors for insulin resistance, metabolic syndrome, coronary heart disease, and cancer, which are all currently leading causes of mortality. Although the combined prevalence of overweight and obesity has increased continuously up to 40–50% in most developed countries, effective therapeutic approaches against these conditions, including behavioral therapy, pharmacotherapy, and bariatric surgery, are very limited. Adipose tissue is a complex organ with profound effects on the homeostasis of the entire body. White adipocytes function as a means of long-term energy storage by accumulating a single large lipid vacuole, which is surrounded by a thin rim of cytoplasm that contains only small amounts of mitochondria. They also produce metabolites and signaling lipids and secrete protein factors (adipokines). Brown and beige adipocytes accumulate numerous small lipid droplets in a multilocular arrangement, contain a large amount of mitochondria-rich cytoplasm, and convert glucose and fatty acids into heat. The production of adipocyte-derived factors changes under different nutritional and pathological conditions that contribute to the pathophysiology of several comorbidities. This Special Issue will focus on metabolic changes and novel molecular pathways observed in obesity, with a high emphasis on adipose tissues that can be targeted in the fight against obesity and metabolic syndrome.

Dr. Kristóf Endre Károly
Dr. Éva Csősz
Dr. Rini Arianti
Guest Editors

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Keywords

  • adipose tissue
  • obesity
  • inflammation
  • thermogenesis
  • adipokines
  • insulin resistance

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Published Papers (1 paper)

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Research

13 pages, 1361 KB  
Article
Anthropometric Obesity Phenotypes in Young Physically Active Men: The Role of Body Composition and Fat Distribution
by Agnieszka Wasiluk, Jerzy Saczuk and Ryszard Asienkiewicz
Life 2025, 15(12), 1808; https://doi.org/10.3390/life15121808 - 25 Nov 2025
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Abstract
Background: BMI does not distinguish fat from lean mass, reducing its usefulness in active young adults. This study assessed obesity phenotypes and their associations with lean mass and adipose tissue distribution. Methods: A total of 174 male university students (mean age 20.88 ± [...] Read more.
Background: BMI does not distinguish fat from lean mass, reducing its usefulness in active young adults. This study assessed obesity phenotypes and their associations with lean mass and adipose tissue distribution. Methods: A total of 174 male university students (mean age 20.88 ± 0.86 years) underwent anthropometric measurements, including BMI, waist circumference (WC), and waist-to-hip ratio (WHR), and body composition assessment using bioelectrical impedance analysis (BIA). Participants were classified into four phenotypes (MHNW, MHO, MUO, and NWO) based on BMI, body fat percentage (%BF), WC, and WHR. One-way ANOVA with Newman–Keuls post hoc tests was used to assess group differences. A multiple linear regression model was applied to determine the independent predictors of %BF. Results: MHNW was the most prevalent phenotype (66.7%), followed by MHO (19.0%), MUO (8.0%), and NWO (6.9%). Significant differences were observed in body composition and fat distribution among phenotypes. BMI poorly reflected %BF. Multiple regression analysis identified WC and WHR as the strongest independent predictors of %BF, whereas BMI was not significant after adjustment. Higher lean body mass in MHNW and MHO was associated with more favorable fat distribution patterns. Conclusions: BMI alone is insufficient to assess metabolic risk in young, physically active adults. WC and WHR showed superior predictive value for body fatness and should complement BMI in metabolic risk evaluation. Including lean body mass and fat distribution measures improves the identification of individuals at risk of metabolic and cardiovascular disorders. Full article
(This article belongs to the Special Issue New Updates in Adipocytes and Adipose Tissue—3rd Edition)
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