Deciphering Antioxidant Defence Mechanisms in Neuronal and Non-neuronal Cells
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: closed (16 February 2024) | Viewed by 7221
Special Issue Editors
Interests: brain aging; neurodegenerative diseases; glioblastoma; hypoxia
Special Issues, Collections and Topics in MDPI journals
Interests: neurodegeneration; Alzheimer’s disease; genetics of dementia; oxidative stress; microRNAs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Throughout life, the brain is constantly exposed to injuries that can exacerbate degenerative processes and accelerate aging. Oxidative stress is a deleterious condition defined as the imbalance between oxidant and antioxidant defences leading to reactive oxygen species (ROS) generation, which oxidizes macromolecules such as lipids, proteins and nucleic acids causing cell death and leading to neurodegeneration. Therefore, cells have evolved defence mechanisms to limit oxidative stress damage and maintain redox homeostasis. Understanding the physiological function of brain cells in response to oxidative injuries, as well as how the crosstalk between neuronal and glial cells is influenced by this condition will be of fundamental importance for the development of new therapeutic interventions focused on limiting oxidative brain injury.
Therefore, in this Special Issue, we invite investigators to contribute with original research articles, as well as review articles focusing on the role of oxidative stress in the pathophysiology of brain aging and neurodegenerative disorders, highlighting the molecular mechanisms of antioxidant defence in neuronal and non-neuronal cells. Understanding the control of redox homeostasis in normal and pathological conditions will be of fundamental importance in tackling brain diseases.
Potential topics include, but are not limited to, the following:
- Molecular basis of oxidative stress on glial cells in the aging brain;
- Neurodegenerative diseases and oxidative stress: the role of glial cells;
- Effects of oxidative stress on lipid metabolism in neurodegenerative diseases;
- Mechanisms of hypoxia-induced oxidative stress in neuronal and non-neuronal cells in neurodegenerative diseases;
- Role of oxidative stress-induced autophagy in neuroprotection;
- Oxidative stress-induced microglial activation in brain aging and neurodegeneration;
- Discovery of novel synthetic antioxidants to limit oxidative stress in the brain;
- Molecular mechanisms of antioxidants in brain aging and neurodegeneration;
- Mechanisms of astrocyte reactivity to oxidative stress in the brain;
- Microglial activation and neurodegenerative diseases: understanding the molecular basis of oxidative stress;
- The role of astrocyte response to oxidative stress in BBB permeability.
You may choose our Joint Special Issue in Brain Sciences.
Dr. Paolo Rosa
Dr. Alessio Crestini
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- oxidative stress
- reactive oxygen species
- ROS
- brain aging
- neurodegeneration
- neuronal loss
- hypoxia
- glial cells
- microglia
- antioxidants
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
