Therapeutic Approaches of Natural Products in Health and Disease

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Pharmaceutical Science".

Deadline for manuscript submissions: closed (31 October 2025) | Viewed by 477

Special Issue Editors


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Guest Editor
Department of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 4000 Plovdiv, Bulgaria
Interests: drug

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Guest Editor
Department of Organic Chemistry, Faculty of Chemistry, University of Plovdiv “Paisii Hilendarski”, 24, Tzar Asen Str., 4000 Plovdiv, Bulgaria
Interests: synthesis; drug discovery; medicinal chemistry; heterocyclic compounds; organic synthesis; hybrid molecules; nanoparticles; drug delivery systems; drug design
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Special Issue Information

Dear Colleagues,

Nature provides an endless supply of biologically active substances, making research into these compounds constantly relevant. This includes both, the discovery of new molecules and the evaluation of new biological activity of already known compounds. For centuries, people have used the benefits of nature in the areas they inhabited, both for food and medicinal purposes. Today, the accumulated knowledge about the benefits of natural products is reaching a much wider audience globally. Modern science allows studying the metabolism of compounds of natural origin at the cellular level, modifying natural molecules in order to obtain derivatives with better activity or lower toxicity, and conducting in-depth studies of a wide range of pharmacological effects.

This Special Issue aims to gather original research and review articles focused on pharmacological activities and the therapeutic potential of natural products. Applying a thorough methodology incorporating in vitro bioassays, and in vivo preclinical evaluations, this special issue elucidates the therapeutic advantages and underlying mechanisms of natural products, metabolites, and derivatives. Contributions that expand the understanding of the potential of these compounds and demonstrate their applications in medicine are encouraged. This special issue calls for interdisciplinary research addressing regulatory, ethical, and precision medicine challenges to advance therapeutic development

Dr. Mina Mihaylova Todorova
Dr. Stoyanka Atanasova
Guest Editors

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Keywords

  • natural products
  • bioactive compounds
  • isolation
  • analysis
  • metabolism
  • in vitro and in vivo experiments
  • pharmacological activity

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Published Papers (1 paper)

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Research

18 pages, 1169 KB  
Article
Chemical Characteristics and Biological Potential of Prunus laurocerasus Fruits
by Mina Todorova, Nadezhda Petkova, Ivan Ivanov, Yulian Tumbarski, Velichka Yanakieva, Ivelina Vasileva, Yoana Barakova, Emiliya Cherneva and Stoyanka Nikolova
Life 2025, 15(12), 1847; https://doi.org/10.3390/life15121847 - 30 Nov 2025
Viewed by 206
Abstract
Fruits of the Laurocerasus officinalis Roem., known as cherry laurel, are found in the Black Sea region. This study examines the phytochemical characterization, antioxidant properties, and antimicrobial potential of cherry laurel’s fruits, variety Novita, cultivated in Southern Bulgaria. The study is significant since [...] Read more.
Fruits of the Laurocerasus officinalis Roem., known as cherry laurel, are found in the Black Sea region. This study examines the phytochemical characterization, antioxidant properties, and antimicrobial potential of cherry laurel’s fruits, variety Novita, cultivated in Southern Bulgaria. The study is significant since it examines the phytochemical profile of this variety’s fruits for the first time. The carbohydrate composition of the fruit was identified. The total polyphenols and flavonoids of five fruit extracts (96% ethanol, 70% ethanol, 50% ethanol, 80% methanol, and water) were determined. The antioxidant potential of these five extracts was evaluated by three methods: DPPH, ABTS, and FRAP. We found that the 96% ethanol extract had the highest content of polyphenols and flavonoids and the highest antioxidant activity values by all three methods. A correlation was established between the content of polyphenols, flavonoids, and antioxidant activity based on the calculated correlation coefficient. The antimicrobial potential of methanolic and aqueous extracts of the fruit of the laurel cherry was evaluated against twenty microorganisms. It was found that the methanolic extracts exhibited moderate to high sensitivity against both Gram-positive and Gram-negative strains, yeast Saccharomyces cerevisiae, and five fungi, while water extracts had moderately sensitive activity against Micrococcus luteus only. Based on the results, we can conclude that the fruits demonstrate good antioxidant and antimicrobial potential. Full article
(This article belongs to the Special Issue Therapeutic Approaches of Natural Products in Health and Disease)
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