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Life
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Advances in Fetal Medicine: From Prenatal Diagnosis to Fetal and...
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Advances in Fetal Medicine: From Prenatal Diagnosis to Fetal and Neonatal Therapy

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Reproductive and Developmental Biology".

Deadline for manuscript submissions: 30 July 2026 | Viewed by 1764

Special Issue Editor

Dr. Przemysław Kosinski

E-Mail Website
Guest Editor
Department of Obstetrics, Perinatology and Gynecology, Medical University of Warsaw, 63A Zwirki i Wigury, 02-091 Warsaw, Poland
Interests: maternal and fetal medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite submissions to the upcoming Special Issue of Life, “Advances in Fetal Medicine: From Prenatal Diagnosis to Fetal and Neonatal Therapy.” This Special Issue aims to showcase cutting-edge research and clinical innovations that are transforming fetal and neonatal care. We welcome original research articles, comprehensive reviews that address the full spectrum of fetal medicine—from novel diagnostic technologies and screening strategies to therapeutic interventions and long-term outcomes.

Contributors are encouraged to submit manuscripts covering topics such as non-invasive prenatal testing, fetal imaging, fetal surgery, genetic and genomic advances, and innovations in neonatal intensive care. Our goal is to create a multidisciplinary platform for clinicians, researchers, and healthcare professionals to share insights that improve perinatal health and outcomes.

This Special Issue offers an opportunity to highlight your work in a high-visibility forum and reach a global audience of scientists and practitioners dedicated to maternal-fetal and neonatal health. We look forward to receiving your valuable contributions.

Dr. Przemysław Kosinski
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fetal medicine
  • prenatal diagnosis
  • non-invasive prenatal testing (NIPT)
  • fetal imaging
  • fetal therapy
  • fetal surgery
  • neonatal intensive care
  • genetic and genomic advances
  • perinatal outcomes
  • maternal-fetal health

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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12 pages, 6437 KB  
Article
The Umbilical Cord Clamp Method—Procedural Description and Safety Assessment of a Novel Method of Umbilical Catheter Fixation After Side Entry Insertion
by Anna Tomaszkiewicz, Piotr Kruczek, Piotr Szymański, Piotr Teplicki, Rita Abu Faraj-Batko, Alina Sobczak, Sonia Kahtan, Boris W. Kramer and Jan Mazela
Life 2025, 15(12), 1935; https://doi.org/10.3390/life15121935 - 18 Dec 2025
Viewed by 204
Abstract
Background: Umbilical venous catheter (UVC) placement is common in neonates but carries risks of migration and infection. This study evaluates safety of a novel fixation technique using the umbilical cord clamp after a side-entry insertion. Methods: A retrospective analysis of 264 neonates was [...] Read more.
Background: Umbilical venous catheter (UVC) placement is common in neonates but carries risks of migration and infection. This study evaluates safety of a novel fixation technique using the umbilical cord clamp after a side-entry insertion. Methods: A retrospective analysis of 264 neonates was conducted at a tertiary center in order to assess safety of the novel UVC fixation method. The new technique involved side-entry catheter insertion without severing the cord, secured to the clamp with a sterile patch. Catheter tip position was confirmed and monitored every 24 h via ultrasound. Results: Catheter migration occurred in 18.9% of cases, mostly inward into the right atrium which was managed by repositioning. Migration into the ductus venosus requiring removal occurred in 0.7% of cases and unscheduled removal due to stump detachment in 1.5%. No central line-associated bloodstream infections (CLABSIs) were observed. Conclusions: The umbilical cord clamp method is a safe, single-operator alternative for UVC fixation. This technique had a low rate of catheter migration, did not increase the risk of infection, and was cost-effective and simple. Full article
(This article belongs to the Special Issue Advances in Fetal Medicine: From Prenatal Diagnosis to Fetal and Neonatal Therapy)
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9 pages, 411 KB  
Case Report
Severe Hemolytic Disease of the Fetus Treated with Serial Intrauterine Transfusions: A Case Report and Review of Current Management
by Olga Olejniczak, Jakub Kornacki and Ewa Wender-Ożegowska
Life 2025, 15(12), 1875; https://doi.org/10.3390/life15121875 - 8 Dec 2025
Viewed by 322
Abstract
Hemolytic disease of the fetus and newborn (HDFN) is a severe complication of pregnancy caused by maternal alloimmunization to fetal red blood cells, leading to significant perinatal morbidity and mortality. The prognosis is particularly poor in cases complicated by fetal hydrops. Prophylactic administration [...] Read more.
Hemolytic disease of the fetus and newborn (HDFN) is a severe complication of pregnancy caused by maternal alloimmunization to fetal red blood cells, leading to significant perinatal morbidity and mortality. The prognosis is particularly poor in cases complicated by fetal hydrops. Prophylactic administration of anti-D immunoglobulin—during pregnancy, postpartum, and after events causing fetomaternal hemorrhage—has substantially reduced the incidence and severity of Rh-related HDFN. Nevertheless, the condition can still occur, either due to omitted prophylaxis or undetected fetomaternal hemorrhage. Definitive management often requires invasive interventions, including cordocentesis and intrauterine transfusions (IUTs), sometimes repeated multiple times, while the optimal timing of delivery remains uncertain, necessitating a careful balance between prematurity and ongoing fetal risk. We report the case of a 35-year-old multipara whose two most recent pregnancies were complicated by HDFN. The first affected pregnancy had a mild course, whereas the second was severe, necessitating multiple intrauterine transfusions (IUTs) throughout gestation. Despite an extremely low initial fetal hematocrit (4.5%), severe hydrops, and the requirement of six intrauterine transfusions (IUTs) during the pregnancy, the infant was delivered at 36 weeks’ gestation with a favorable postnatal outcome. This case report provides a comprehensive overview of intrauterine transfusion methodology, post-transfusion pregnancy monitoring, timing of successive IUTs, and optimal delivery planning in pregnancies complicated by HDFN. Full article
(This article belongs to the Special Issue Advances in Fetal Medicine: From Prenatal Diagnosis to Fetal and Neonatal Therapy)
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