Psychiatric Treatment and Metabolic Dysregulation: From Pathophysiology to Therapeutic Implications
A Special Issue of Life (ISSN 2075-1729) belonging to the section "Medical Research".
Deadline for manuscript submissions: 28 February 2027 | Viewed by 307
Editors
Interests: non-alcoholic fatty liver disease; metabolic-associated fatty liver disease; diabetes; clinical pharmacology
Special Issues, Collections and Topics in MDPI journals
Interests: arrhythmias; intensive cardiac therapy; metabolic disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Psychiatric disorders and metabolic dysfunction are closely interrelated, creating a major challenge for contemporary mental health care. In addition to the intrinsic metabolic vulnerability observed in many patients with psychiatric conditions, a wide range of psychotropic treatments may contribute to clinically relevant metabolic disturbances, including weight gain, insulin resistance, dyslipidemia, and increased cardiovascular risk. These adverse effects can compromise treatment adherence, worsen long-term outcomes, and substantially increase the burden of disease. At the same time, growing evidence indicates that biological, genetic, inflammatory, endocrine, and lifestyle-related factors all contribute to interindividual variability in metabolic risk during psychiatric therapy. This makes the topic highly relevant for both basic and clinical research.
This Special Issue aims to bring together cutting-edge research on the mechanisms, predictors, prevention, and management of metabolic disorders associated with psychiatric therapy. Its scope aligns with the Journal’s interest in clinically relevant, translational, and multidisciplinary research at the interface of psychiatry, metabolism, pharmacology, and precision medicine. We particularly welcome studies that improve understanding of psychopharmacology-induced metabolic dysregulation and support safer, more individualized treatment strategies. The aim is to provide a platform for work that advances both mechanistic insight and practical solutions for improving metabolic health in psychiatric therapy.
In this Special Issue, original research articles and reviews are welcome. Research areas may include, but are not limited to, the following:
- Metabolic effects of antipsychotics, antidepressants, mood stabilizers, and other psychotropic agents;
- Biomarkers and clinical predictors of metabolic risk;
- Neuroendocrine, inflammatory, and gut–brain mechanisms;
- Pharmacogenomics and precision psychiatry;
- Preventive and therapeutic interventions to reduce metabolic burden;
- Real-world studies and long-term cardiometabolic outcomes.
We look forward to receiving your contributions.
Dr. Marcin Kosmalski
Dr. Monika Różycka-Kosmalska
Guest Editors
Manuscript Submission Information
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Keywords
- psychiatric therapy
- metabolic disorders
- psychopharmacology
- metabolic dysregulation
- cardiometabolic risk
- antipsychotics
- antidepressants
- precision psychiatry
- biomarkers
- psychological treatment
- neurovegetative alterations
- psychosomatic responses
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