Journal of Personalized Medicine

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Special Issue Information

Dear Colleagues,

Precision medicine is reshaping the paradigm of cancer treatment, and the management of gastric cancer has also recently moved toward a tailored therapeutic approach.

This Special Issue aims to highlight the most recent acquisitions around the molecular and cellular biology of gastric cancer, and it focuses on the most compelling advances in tailoring of systemic therapies in patients affected by this disease. The growing knowledge about the genomic landscape of gastric cancer has paved the way for the development of novel targeted drugs and the identification of relevant predictive factors.

Beyond the introduction of anti-HER2 agents more than ten years ago and, more recently, anti-VEGF drugs, the most promising targets include claudin 18.2 and FGFR, but many trials are ongoing.

Articles investigating genetic and epigenetic drivers or other significantly altered pathways, as well as preclinical or clinical studies focused on the molecular profiling, are welcome.

Dr. Valeria Merz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

gastric cancer
personalized medicine
tailored therapy
predictive factors
translational research
target therapy

Published Papers (2 papers)

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Research

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15 pages, 6363 KiB

Open AccessArticle

Gastric Cancer Angiogenesis Assessment by Dynamic Contrast Harmonic Imaging Endoscopic Ultrasound (CHI-EUS) and Immunohistochemical Analysis—A Feasibility Study

by Victor Mihai Sacerdoțianu, Bogdan Silviu Ungureanu, Sevastiţa Iordache, Sergiu Marian Cazacu, Daniel Pirici, Ilona Mihaela Liliac, Daniela Elena Burtea, Valeriu Șurlin, Cezar Stroescu, Dan Ionuț Gheonea and Adrian Săftoiu

J. Pers. Med. 2022, 12(7), 1020; https://doi.org/10.3390/jpm12071020 - 21 Jun 2022

Viewed by 1389

Abstract

Tumor vascular perfusion pattern in gastric cancer (GC) may be an important prognostic factor with therapeutic implications. Non-invasive methods such as dynamic contrast harmonic imaging endoscopic ultrasound (CHI-EUS) may provide details about tumor perfusion and could also lay out another perspective for angiogenesis assessment. Methods: We included 34 patients with GC, adenocarcinoma, with CHI-EUS examinations that were performed before any treatment decision. We analyzed eighty video sequences with a dedicated software for quantitative analysis of the vascular patterns of specific regions of interest (ROI). As a result, time-intensity curve (TIC) along with other derived parameters were automatically generated: peak enhancement (PE), rise time (RT), time to peak (TTP), wash-in perfusion index (WiPI), ROI area, and others. We performed CD105 and CD31 immunostaining to calculate the vascular diameter (vd) and the microvascular density (MVD), and the results were compared with CHI-EUS parameters. Results: High statistical correlations (p < 0.05) were observed between TIC analysis parameters MVD and vd CD31. Strong correlations were also found between tumor grade and 7 CHI-EUS parameters, p < 0.005. Conclusions: GC angiogenesis assessment by CHI-EUS is feasible and may be considered for future studies based on TIC analysis. Full article

(This article belongs to the Special Issue Advances of Personalized Medicine for Gastric Cancer)

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Review

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16 pages, 1044 KiB

Open AccessReview

High-Salt Diet Exacerbates H. pylori Infection and Increases Gastric Cancer Risks

by Vyshnavy Balendra, Chiara Amoroso, Barbara Galassi, Josephine Esposto, Claudia Bareggi, Jennie Luu, Lucia Scaramella and Michele Ghidini

J. Pers. Med. 2023, 13(9), 1325; https://doi.org/10.3390/jpm13091325 - 28 Aug 2023

Cited by 2 | Viewed by 3072

Abstract

Gastric cancer ranks as the fifth-leading contributor to global cancer incidence and the fourth-highest in terms of cancer-related mortality. Helicobacter pylori (H. pylori) infection leads to inflammation and ulceration, atrophic and chronic gastritis, and eventually, increases the risk of developing gastric adenocarcinoma. In this paper, we delve into the combined impact of a high-salt diet (HSD) and concurrent H. pylori infection, which act as predisposing factors for gastric malignancy. A multitude of mechanisms come into play, fostering the development of gastric adenocarcinoma due to the synergy between an HSD and H. pylori colonization. These encompass the disruption of mucosal barriers, cellular integrity, modulation of H. pylori gene expression, oxidative stress induction, and provocation of inflammatory responses. On the whole, gastric cancer patients were reported to have a higher median sodium intake with respect to healthy controls. H. pylori infection constitutes an additional risk factor, with a particular impact on the population with the highest daily sodium intake. Consequently, drawing from epidemiological discoveries, substantial evidence suggests that diminishing salt intake and employing antibacterial therapeutics could potentially lower the susceptibility to gastric cancer among individuals. Full article

(This article belongs to the Special Issue Advances of Personalized Medicine for Gastric Cancer)

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