Clinical Advances in Dermatology: Pathophysiology, Diagnosis and Treatment

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: 25 May 2025 | Viewed by 4221

Special Issue Editors


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Guest Editor

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Guest Editor
Dermatology and Venereology, Hospital Universitario Reina Sofia, 14004 Córdoba, Spain
Interests: psoriasis; atopic dermatitis; urticaria; biosimilars pediatric dermatology; trichology

Special Issue Information

Dear Colleagues,

The eruption of great therapeutic advances in our field, with the incorporation of biological drugs and molecules such as JAK (Janus Kinase) inhibitors, has advanced the knowledge of diagnosis thanks to new scales and results reported by patients that are being included in studies, clinical trials and randomized trials. New therapeutic targets and a better understanding of the pathophysiology of some immune-mediated diseases, such as psoriasis, atopic dermatitis, vitiligo, hidradenitis, urticaria or alopecia areata, have also emerged. In this issue, we will delve into the advances that are taking place in the different fields of clinical dermatology regarding these pathologies.

Dr. Ricardo Ruíz-Villaverde
Dr. Manuel Galán-Gutiérrez
Guest Editors

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Keywords

  • psoriasis
  • atopic dermatitis
  • laser therapy
  • urticaria
  • alopecia areata
  • treatment
  • biological treatment
  • JAK (Janus Kinase) inhibitors

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Published Papers (3 papers)

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Research

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8 pages, 730 KiB  
Article
Efficacy and Safety of Intra-Class Switching from Ixekizumab to Secukinumab in Patients with Plaque Psoriasis: A Multicenter Retrospective Study
by Nicoletta Bernardini, Annunziata Dattola, Raimondo Rossi, Gianluca Pagnanelli, Paolo Amerio, Laura Atzori, Cristina Mugheddu, Viviana Lora, Domenico Giordano, Lucia Finistauri Guacci, Severino Persechino, Antonio Giovanni Richetta, Nevena Skroza and Concetta Potenza
J. Pers. Med. 2024, 14(12), 1169; https://doi.org/10.3390/jpm14121169 - 22 Dec 2024
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Abstract
Background: the present multicenter retrospective study aimed to evaluate the efficacy and safety of intra-class switching between interleukin-17A (IL-17A) inhibitors, specifically from ixekizumab to secukinumab, in patients with plaque psoriasis. Methods: this study included 11 patients (6 male, 5 female) who had previously [...] Read more.
Background: the present multicenter retrospective study aimed to evaluate the efficacy and safety of intra-class switching between interleukin-17A (IL-17A) inhibitors, specifically from ixekizumab to secukinumab, in patients with plaque psoriasis. Methods: this study included 11 patients (6 male, 5 female) who had previously received ixekizumab and then were switched to secukinumab. Patients’ PASI, DLQI, and pain VAS (in those with psoriatic arthritis) were evaluated at weeks 16, 24, 54, and 98. Results: PASI-90 was reached in 10 (91%) cases at week 24. One patient experienced secondary failure to secukinumab at week 98. No adverse events were reported. Conclusions: overall, the majority of patients experienced a favorable response to secukinumab, suggesting that it may be an effective treatment option for patients with an inadequate response or loss of efficacy to ixekizumab. Full article
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12 pages, 277 KiB  
Article
Changes in Serum IL-12 Levels following the Administration of H1-Antihistamines in Patients with Chronic Spontaneous Urticaria
by Corina Daniela Ene, Milena Tocut, Mircea Tampa, Simona Roxana Georgescu, Clara Matei, Iulia Maria Teodora Leulescu, Ilinca Nicolae and Cosmin Ene
J. Pers. Med. 2024, 14(3), 295; https://doi.org/10.3390/jpm14030295 - 10 Mar 2024
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Abstract
Introduction. Research regarding the role of the IL-12 cytokine family in modulating immune and inflammatory responses is continuously evolving. In this study, the contribution of the p35 and p40 subunits as monomers (noted as IL-12p35 and IL-12p40) and heterodimers (noted as IL-12p70 or [...] Read more.
Introduction. Research regarding the role of the IL-12 cytokine family in modulating immune and inflammatory responses is continuously evolving. In this study, the contribution of the p35 and p40 subunits as monomers (noted as IL-12p35 and IL-12p40) and heterodimers (noted as IL-12p70 or IL-12p35/p40) was analysed in the pathophysiology and progression of chronic spontaneous urticaria (CSU). Materials and methods. We conducted a longitudinal, case–control study involving 42 CSU cases and 40 control cases comprising adults without associated conditions. Serial measurements were performed to assess the serum levels of IL-12p70, IL-12p35, and IL-12p40 at the onset of the disease (pre-therapy phase) and 6 weeks after the initiation of the treatment (post-therapy phase). Results. During the pre-therapeutic phase of CSU, elevated serum levels of IL-12 cytokine subtypes were detected compared to the control group. The relationship between IL-12 profiles and the course of CSU highlighted the pro-inflammatory role of IL-12p70 and the anti-inflammatory role of IL-12p35. Significant correlations were observed between IL-12p70 levels and the duration of the disease, as well as between IL-12 and the effectiveness of H1-antihistamines. Conclusions. The molecular background for the pleiotropic activities mediated by IL-12-derived cytokines in patients with CSU lies in the strict regulation of the production, signalling pathways, and cytokine-specific influences on the same pathophysiological events. The results of the present study suggest that the superficial layers of the skin serve as a cellular source of IL-12, a cytokine produced through antigenic stimulation. In patients with CSU, we identified independent, additive, or divergent functions of IL-12p70, IL-12p35, and IL-12p40, all relevant to systemic inflammation. These findings prove that the prototype programming of IL-12 is abnormal in CSU. Full article

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8 pages, 6608 KiB  
Case Report
Superficial Anaplastic Lymphoma Kinase-Rearranged Myxoid Spindle Cell Neoplasm in the Buttock: A Case Report
by Jong-Hyup Kim, In-Chang Koh, Hoon Kim, Soo-Yeon Lim, Joon-Hyuk Choi and Kun-Young Kwon
J. Pers. Med. 2024, 14(8), 858; https://doi.org/10.3390/jpm14080858 - 13 Aug 2024
Cited by 2 | Viewed by 997
Abstract
Anaplastic lymphoma kinase (ALK) is detected in both normal and oncological developmental tissues. Among ALK-related tumors, superficial ALK-rearranged myxoid spindle cell neoplasm (SAMS) is a rare, soft tissue tumor characterized by the immunophenotypical co-expression of CD34 and S100. Here, we describe a patient [...] Read more.
Anaplastic lymphoma kinase (ALK) is detected in both normal and oncological developmental tissues. Among ALK-related tumors, superficial ALK-rearranged myxoid spindle cell neoplasm (SAMS) is a rare, soft tissue tumor characterized by the immunophenotypical co-expression of CD34 and S100. Here, we describe a patient with this rare tumor and outline its clinical and radiological characteristics. A 28-year-old woman with diabetes, hypertension, and panic disorder presented with discomfort caused by a rubbery mass on the left buttock that had persisted for 10 years. Computed tomography revealed a multilobulated hypodense mass with small internal enhancing foci, posing challenges for the exact diagnosis of the lesion. The entire lesion was excised with clear resection margins. An 8.0 × 6.0 cm, well-circumscribed tumor with a lobular growth pattern was observed in the deep subcutaneous tissue. Light microscopy revealed epithelioid, ovoid, and spindle-shaped cells with a reticular cordlike pattern. Immunohistochemistry results were positive for S100, CD34, and vimentin. Break-apart fluorescence in situ hybridization assay results for ALK were also positive. These findings were consistent with those of SAMS. This case suggests that SAMS should be considered when identifying large nonspecific masses during clinical and imaging evaluation. Full article
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