Epidemiology and Risk Factors of Skin Cancer

Abstract submission deadline

closed (30 July 2024)

Manuscript submission deadline

closed (30 September 2024)

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Topic Information

Dear Colleagues,

Skin cancer is the most frequent oncological diagnosis worldwide. The global prevalence of melanoma has increased from 0.02% in 1990 to 0.03% in 2017. On the other hand, the prevalence of non-melanoma skin cancer (basal cell carcinoma and squamous cell carcinoma) has increased from 0.01% in 1990 to 0.03% in 2017. Despite numerous efforts and campaigns on promotion and prevention strategies, its incidence, prevalence, and disability-adjusted life years continue to increase. The constant increase in the prevalence and morbidity of skin cancer in recent decades is a current epidemiological challenge, which is why it is essential to promote community participation and empowerment and to develop and disseminate new and promising preventive strategies. Exposure to ultraviolet radiation is the most important modifiable environmental risk factor for the development of skin cancer. However, it is clear that this is not the only contributing factor. Having knowledge of global incidence and prevalence, determining new risk factors, and better characterizing known factors are essential in a health problem such as skin cancer.

In this topic, we focus on the current state of knowledge on the epidemiology and risk factors of skin cancer, both melanoma and non-melanoma, including not only basal cell carcinoma and squamous cell carcinoma but also other less-prevalent cancers such as Merkel cell carcinoma.

The topic Epidemiology and Risk Factors of Skin Cancer provides a platform to publish manuscripts from different disciplines including exposure assessment science, epidemiology, intervention studies, and risk and health impact assessment, as well as population studies, big data studies, and studies on the application of artificial intelligence in this field. We preferably seek new research papers and systematic reviews, although other types of contributions such as narrative reviews, case series, brief reports, etc., may also be considered.

Dr. José Juan Pereyra-Rodríguez
Dr. Ricardo Ruiz-Villaverde
Prof. Dr. Jose-Carlos Armario-Hita
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Biomedicines biomedicines	3.9	5.2	2013	14.6 Days	CHF 2600
Cancers cancers	4.5	8.0	2009	17.4 Days	CHF 2900
Clinics and Practice clinpract	1.7	2.6	2011	20.8 Days	CHF 1600
Dermato dermato	-	-	2021	37.6 Days	CHF 1000
Life life	3.2	4.3	2011	17.8 Days	CHF 2600
Current Oncology curroncol	2.8	3.3	1994	19.8 Days	CHF 2200

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Published Papers (2 papers)

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All Biomedicines Cancers Clinics and Practice Dermato Life Current Oncology

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8 pages, 681 KiB  

Open AccessArticle

Factors Influencing Margin Clearance and the Number of Stages of Mohs Micrographic Surgery in Basal Cell Carcinoma: A Retrospective Chart Review

by Vijaya T. Daniel, Vincent Azzolino, Maria Abraham, Nicholas Leonard, Kaitlin Blankenship, Karan Lal, Julie Flahive, Regina Brown, Elizabeth Tkachenko, Shereen Teymour, Abdel Kader El Tal and Bassel H. Mahmoud

Cancers 2024, 16(13), 2380; https://doi.org/10.3390/cancers16132380 - 28 Jun 2024

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Abstract

How patient and tumor factors influence clearance margins and the number of Mohs Micrographic Surgery (MMS) stages when treating basal cell carcinoma (BCC) remains widely uncharacterized. It is important to elucidate these relationships, as surgical outcomes may be compared nationally between colleagues. Our [...] Read more.

How patient and tumor factors influence clearance margins and the number of Mohs Micrographic Surgery (MMS) stages when treating basal cell carcinoma (BCC) remains widely uncharacterized. It is important to elucidate these relationships, as surgical outcomes may be compared nationally between colleagues. Our objective is to evaluate the relationships between defect size and patient demographics, as well as between BCC subtypes and the number of MMS stages. Our second objective is to compare practice patterns and characteristics of patients requiring MMS at academic centers and private practices. A retrospective chart review was performed using data collected at academic centers (2015–2018) and private practices (2011–2018) of BCC patients older than 18 years old who underwent MMS. In total, 7651 patients with BCC requiring MMS were identified. Academic center adjusted analyses demonstrated clearance margins 0.1 mm higher for every year’s increase in age (p < 0.0001) and 0.25 increase in MMS stages for high-risk BCC (p < 0.0001). Private practice adjusted analyses demonstrated clearance margins 0.04 mm higher for every year’s increase in age (p < 0.0001). Clearance margins correlate with older age, and additional MMS stages correlate with high-risk BCC, suggesting the role patient and tumor factors may play in predicting tumor clearance and MMS stages. Full article

(This article belongs to the Topic Epidemiology and Risk Factors of Skin Cancer)

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15 pages, 780 KiB  

Open AccessArticle

Evaluation of a Population-Based Targeted Screening Approach for Skin Cancer with Long-Time Follow-Up in Austria including Potential Effects on Melanoma Mortality

by Wolfgang Brozek, Patrick Clemens, Hanno Ulmer, Nina Häring, Hans Concin, Emanuel Zitt and Gabriele Nagel

Cancers 2024, 16(7), 1283; https://doi.org/10.3390/cancers16071283 - 26 Mar 2024

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Abstract

Background: whether screening for skin cancer affects melanoma-specific mortality in a population-based setting remains unclear. Methods: in this population-based cohort study, we characterized and evaluated a skin cancer prevention program following a targeted screening approach conducted in 1989–1994 in the Austrian province Vorarlberg, [...] Read more.

Background: whether screening for skin cancer affects melanoma-specific mortality in a population-based setting remains unclear. Methods: in this population-based cohort study, we characterized and evaluated a skin cancer prevention program following a targeted screening approach conducted in 1989–1994 in the Austrian province Vorarlberg, with follow-up until 2019. The general population and attendees of a health examination program served for comparison. Results: in the screening program including full follow-up until 2019, 207 invasive and 187 in situ melanomas were identified in 8997 individuals. Incidences of invasive and in situ melanomas were elevated compared to the general population (IRR 2.92, 95%-CI 2.49–3.41, and IRR 4.13, 95%-CI 3.53–4.83, respectively) and the health examination program (HR 3.02, 95%-CI 2.59–3.52, and HR 3.90, 95%-CI 3.30–4.61, respectively). Breslow thickness and Clark’s level at time of invasive diagnosis were significantly lower in 1989–2019, but the tumor characteristics of the melanomas diagnosed during 1989–1994 did not differ from the comparison groups. Moreover, melanoma mortality was significantly elevated in the screening program (IRR 1.66, 95%-CI 1.00–2.75 vs. the general population, HR 2.12, 95%-CI 1.25–3.61 vs. the health examination cohort). Melanoma mortality in Vorarlberg declined until 2004, though statistically non-significantly. Conclusions: given the uncertain effectiveness and high public expenditures of population-wide mass screening programs, primary prevention and targeted risk-based skin cancer screening might be promising alternatives. Full article

(This article belongs to the Topic Epidemiology and Risk Factors of Skin Cancer)

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