Neurodegenerative Diseases: Molecular Pathology and Personalized Treatment
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Mechanisms of Diseases".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 115
Special Issue Editor
Interests: neurodegenerative diseases; neurodegeneration; neuroimaging; neurobiology and brain physiology; behavioural neuroscience
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, amyotrophic lateral sclerosis, and frontotemporal dementia, pose a major challenge for healthcare systems worldwide. Despite significant advances in understanding their molecular pathology, effective disease-modifying treatments remain elusive. This Special Issue on Neurodegenerative Diseases: Molecular Pathology and Personalized Treatment aims to combine cutting-edge research exploring the molecular mechanisms underlying these disorders and innovative strategies for personalized therapeutic interventions.
We welcome contributions that examine neurodegenerative pathology at the genetic, epigenetic, and proteomic levels, including studies on protein misfolding, neuroinflammation, mitochondrial dysfunction, and synaptic degeneration. Research employing advanced methodologies such as single-cell transcriptomics, multi-omics approaches, neuroimaging, and electrophysiology is highly encouraged.
This issue will highlight translational research and precision medicine approaches, including biomarker discovery, individualized risk assessment, and targeted therapeutic strategies, such as gene therapy, RNA-based treatments, neuroprotective agents, and personalized neuromodulation techniques. Studies integrating computational modelling, artificial intelligence, and machine learning to refine patient stratification and treatment prediction are welcome.
Additionally, we seek investigations into disease heterogeneity, the role of sex and ageing in neurodegeneration, and novel clinical trial designs that address patient-specific responses to therapy. Contributions from interdisciplinary collaborations that bridge basic, translational, and clinical research are encouraged to provide a comprehensive understanding of disease mechanisms and the path toward more effective, individualized treatments.
By fostering dialogue between molecular neuroscientists, clinicians, and computational biologists, this Special Issue aims to drive forward the next generation of personalized interventions for neurodegenerative diseases.
We invite original research articles, reviews, and other types contributing to this evolving field.
Dr. Oscar Arias-Carrion
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neurodegeneration
- molecular pathology
- precision medicine
- biomarkers
- personalized therapeutics
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