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Special Issues
Arthroplasty and Personalized Medicine: Updates and Challenges
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Arthroplasty and Personalized Medicine: Updates and Challenges

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Methodology, Drug and Device Discovery".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 2259

Special Issue Editors

Dr. Eugenio Jannelli

E-Mail Website
Guest Editor
1. Orthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy
2. Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy
Interests: arthroplasty; orthopaedics; fracture; traumatology
Special Issues, Collections and Topics in MDPI journals
Dr. Michela Saracco

E-Mail
Guest Editor Assistant
Department of Orthopaedics, University of Naples “Federico II”, 80131, Naples, Italy
Interests: arthroplasty; orthopaedics; fracture; traumatology; orthoplastic; limbs’ reconstructive microsurgery

Special Issue Information

Dear Colleagues,

This Special Issue aims to delve into the new topic of personalized medicine applied to orthopedic surgery, especially arthroplasty and orthobiology.

Personalized, or precision, medicine is an emerging branch of the medicine. Its scope is to provide prevention and treatment strategies based on specific phenotypes and genotypes characteristics. It could be seen as an evolution of medicine, which offers the possibility to offer the most effective and safe treatment for our patients.

In particular, research areas will include the following:

  • Personalized medicine and orthopedic surgery;
  • How personalized medicine can be applied to prosthetic surgery;
  • “Custom-made” prosthesis in primary and revision implants;
  • How personalized medicine has changed orthopedic surgery in recent years;
  • Precision-medicine approach applied to orthobiology and joint replacements;
  • Personalized medicine and tissue regeneration in orthopedics and orthoplastic.

Both original research and systematic reviews are welcome.

Dr. Eugenio Jannelli
Guest Editor

Dr. Michela Saracco
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • personalized medicine
  • personalized orthopedic surgery
  • primary and revision arthroplasties
  • personalized orthoplastic approach
  • personalized orthobiology

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

15 pages, 2933 KB  
Article
Does Intraoperative Navigation Improve K-Wire Positioning in Reverse Shoulder Arthroplasty?—A New Approach
by Timo Blaszczyk, Georg Gosheger, Jonathan Wohlmuth and Vincent Hofbauer
J. Pers. Med. 2025, 15(11), 509; https://doi.org/10.3390/jpm15110509 - 29 Oct 2025
Viewed by 192
Abstract
Background/Objectives: In reverse shoulder arthroplasty (RSA), precise K-wire positioning of the glenoid component is critical to prevent complications such as glenoid loosening or instability as well as premature implant failure. Optimal component placement must adhere to individualized preoperative plans to account for patient-specific [...] Read more.
Background/Objectives: In reverse shoulder arthroplasty (RSA), precise K-wire positioning of the glenoid component is critical to prevent complications such as glenoid loosening or instability as well as premature implant failure. Optimal component placement must adhere to individualized preoperative plans to account for patient-specific anatomical conditions. Conventional methods often fail to achieve this level of accuracy, undermining the need for personalized medicine. Intraoperative navigation systems are growing in use to improve accuracy in orthopedic surgery. This study aimed to compare the accuracy of K-wire positioning in a 3D-printed model of the scapula using conventional versus navigated methods. Methods: We recruited 20 participants: 10 experienced surgeons and 10 inexperienced medical students. Each participant performed four K-wire drillings—two with conventional instruments and two with an intraoperative navigation system. A novel target system, BoneTrack3D, was used to measure accuracy. We assessed the absolute deviation of the entry and exit points as well as the three-dimensional drilling angle. Results: The navigated method was significantly more accurate for all measured parameters at a family-wise significance level of α = 0.05. The median absolute deviation for the entry point was 1.6 mm with navigation versus 3.0 mm with the conventional method (p < 0.001). Similarly, the exit point deviation was 1.8 mm with navigation versus 6.7 mm conventionally (p < 0.001). The drilling angle deviation also showed significant improvement with navigation, at 2.6° compared to 8.9° conventionally (p < 0.001). However, the navigated method took longer, with a median drilling time of 100.0 s compared to 55.0 s for the conventional method (p < 0.001). The navigated method provided consistent and superior results regardless of a participant’s surgical experience. Conclusions: Navigated techniques for K-wire positioning in RSA demonstrate enhanced accuracy in a 3D-printed model, effectively executing a precise, patient-specific preoperative plan. This could be a direct contribution to personalized medicine, ensuring the final implant alignment is tailored to the individual’s anatomy. Furthermore, intraoperative navigation may contribute to a flatter learning curve, thereby increasing accessibility for surgeons with varying levels of experience. Although navigation introduces additional costs and longer initial procedure times, these drawbacks could be offset by improved technical outcomes and a reduced risk of complications. Future studies, including randomized clinical trials and cost-effectiveness analyses, should seek to validate these results in clinical settings with longer follow-up periods and larger patient cohorts to define long-term value and utility of navigation systems in reverse shoulder arthroplasty. Full article
(This article belongs to the Special Issue Arthroplasty and Personalized Medicine: Updates and Challenges)
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