Recent Advances in Biomaterials for Imaging and Disease Treatment

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials and Devices for Healthcare Applications".

Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 885

Special Issue Editor

School of Science, Harbin Institute of Technology, Shenzhen 518055, China
Interests: polymer chemistry; molecular imaging probes; nanomedicines; prodrugs; aggregation-induced emission; fluorescence imaging; photoacoustic imaging; microscopy; wide-field imaging; two photon imaging; second harmonic imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nowadays, the exploitation of biomaterials for advanced imaging and therapy of different diseases is burgeoning. When improvised by using modern-day polymer chemistry and nanotechnology, biomaterials play an important role in boosting the overall imaging and therapeutic outcomes. Imaging modalities like magnetic resonance imaging (MRI), fluorescence imaging (FI), PET/SPET imaging, CT imaging, ultrasound imaging, photoacoustic imaging, and Cerenkov luminescence tomography have been extensively studied, with a particular focus on how to use biomaterial-based imaging agents to amplify imaging fidelity and combine therapy for real-time monitoring therapy.

Herein, imaging-guided therapy has become a crucial modality in recent times. Inorganic and organic systems have mostly been explored in this domain over the last few years. However, their toxicity, pharmacokinetics, pharmacodynamics, and other physicochemical properties restrict them from being translated clinically. Recently, scientists started exploring the potential of biomaterials for imaging and therapeutic applications. It is worth noting that advanced nanoprecipitation techniques and a few other synthetic procedures such as organic–inorganic hybrids, bioconjugation, composite formation, polymeric coating technology, and solid–lipid system formation make biomaterials more fruitful in this domain. On the one hand, biomaterials are less expensive, and the modification of such materials is easier for the therapeutic regime. On the other hand, their presence can make samples more vulnerable to diseased microenvironments. For example, the penetration, adhesion, and cellular permeability of biomaterials are better than any other inorganic systems. Even in drug delivery, biomaterials are the wisest option due to their sustained drug and other payload release capacities. From the imaging point of view, biomaterials offer enormous potential due to their extensive adsorption and uptake capabilities. Moreover, their modification makes it easier for any foreign molecule/functional groups for molecular imaging to be accommodated. Henceforth, biomaterials could be a game-changer in the coming years if properly improvised and administrated clinically. 

Thus, we welcome the submission of review and research papers from different domains of therapy and imaging related to biomaterials research. This Special Issue will also highlight the advances made in these imaging and therapeutic paradigms for treating different diseases such as cancer, inflammation, bacterial infections, wound-healing applications, cardiovascular diseases, bone diseases, tissue engineering, and neurodegenerative diseases. 

Dr. Bing Guo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • imaging-guided therapy
  • theranostics
  • drug delivery systems
  • targeted therapy
  • bacterial infections
  • wound healing
  • anticancer therapy
  • antibacterial therapy
  • inflammation
  • bone tissue engineering
  • cardio vasculature diseases
  • MRI
  • photoacoustic imaging
  • NIR-II (near-infrared II) fluorescence
  • computed tomography
  • SPECT and PET imaging

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

17 pages, 10421 KiB  
Article
Ultrasound-Enhanced Tumor Penetration of Carrier-Free Nanodrugs for High-Efficiency Chemo-Photodynamic Therapy of Breast Cancer
by Yun Xiang, Shiyu Liang and Ping Wang
J. Funct. Biomater. 2025, 16(6), 206; https://doi.org/10.3390/jfb16060206 - 3 Jun 2025
Viewed by 301
Abstract
In recent years, chemo-photodynamic combinational therapy has become increasingly popular in treating breast cancer. However, the limited accumulation of nanodrugs into tumors (less than 1% of the injected dose) impacts therapeutic efficacy to an extreme extent. Herein, the photosensitizer Chlorin e6 (Ce6) and [...] Read more.
In recent years, chemo-photodynamic combinational therapy has become increasingly popular in treating breast cancer. However, the limited accumulation of nanodrugs into tumors (less than 1% of the injected dose) impacts therapeutic efficacy to an extreme extent. Herein, the photosensitizer Chlorin e6 (Ce6) and the chemotherapeutic drug rhein were self-assembled to form a carrier-free nanodrug (RC NPs) with good stability and a high drug loading rate (nearly 100%). In vitro, the phototoxicity of RC NPs resulted in a mere 17.8% cell viability. Ultrasound (US) irradiation was applied to increase the permeability of tumor blood vessels, thus greatly enhancing the drug accumulation of RC NPs in tumor tissues (1.5 times that of the control group). After uptake by tumor cells, Ce6 could produce a significant amount of reactive oxygen species (ROS) when exposed to laser irradiation, while rhein could inhibit tumor cell proliferation and affect mitochondrial membrane potential, inducing tumor cell apoptosis through the mitochondria-dependent apoptosis pathway, thus effectively realizing the combined effect of PDT and chemotherapy. The final tumor inhibition rate reached 93.7%. Taken together, RC NPs strengthen the enhanced permeability and retention (EPR) effect when exposed to US irradiation and exhibit better tumor suppression, which provides new insights into chemo-photodynamic combination treatment for clinical breast cancer. Full article
(This article belongs to the Special Issue Recent Advances in Biomaterials for Imaging and Disease Treatment)
Show Figures

Figure 1

Back to TopTop