Recent Advances in NIR-II Fluorescence Imaging-Based Cancer Treatment

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 1477

Special Issue Editor

School of Science, Harbin Institute of Technology, Shenzhen 518055, China
Interests: polymer chemistry; molecular imaging probes; nanomedicines; prodrugs; aggregation-induced emission; fluorescence imaging; photoacoustic imaging; microscopy; wide-field imaging; two photon imaging; second harmonic imaging
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Dear Colleagues,

NIR-II (Near-Infrared II) fluorescence imaging has emerged as a promising tool for advancing cancer theranostics, particularly in drug delivery. This innovative approach involves utilizing the unique optical properties of NIR-II light, which penetrates biological tissues more effectively than visible wavelengths. By employing NIR-II fluorescence imaging, researchers can visualize and track drug delivery processes with unprecedented depth and clarity, enhancing precision in cancer theranostics. Integrating NIR-II fluorescence imaging into drug delivery systems allows real-time monitoring of therapeutic agents, enabling dynamic assessments of their distribution, pharmacokinetics, pharmacodynamics, and overall efficacy within the tumor microenvironment. Apart from this, NIR-II fluorescence can be combined with other imaging modalities, which could be useful for different biomedical applications. In reality, NIR-II fluorescence imaging-guided drug delivery holds great promise for improving the accuracy and efficiency of cancer theranostics, accompanying a new era of personalized and targeted cancer treatment strategies.

Dr. Bing Guo
Guest Editor

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Keywords

  • NIR-II (Near-Infrared II) fluorescence
  • cancer theranostics
  • drug delivery
  • targeted cancer treatment

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Published Papers (1 paper)

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Review

22 pages, 7760 KiB  
Review
Chemodynamic Therapy of Glioblastoma Multiforme and Perspectives
by Zia Ullah, Yasir Abbas, Jingsi Gu, Sai Ko Soe, Shubham Roy, Tingting Peng and Bing Guo
Pharmaceutics 2024, 16(7), 942; https://doi.org/10.3390/pharmaceutics16070942 - 15 Jul 2024
Viewed by 1117
Abstract
Glioblastoma multiforme (GBM), a potential public health issue, is a huge challenge for the advanced scientific realm to solve. Chemodynamic therapy (CDT) based on the Fenton reaction emerged as a state-of-the-art therapeutic modality to treat GBM. However, crossing the blood–brain barrier (BBB) to [...] Read more.
Glioblastoma multiforme (GBM), a potential public health issue, is a huge challenge for the advanced scientific realm to solve. Chemodynamic therapy (CDT) based on the Fenton reaction emerged as a state-of-the-art therapeutic modality to treat GBM. However, crossing the blood–brain barrier (BBB) to reach the GBM is another endless marathon. In this review, the physiology of the BBB has been elaborated to understand the mechanism of crossing these potential barriers to treat GBM. Moreover, the designing of Fenton-based nanomaterials has been discussed for the production of reactive oxygen species in the tumor area to eradicate the cancer cells. For effective tumor targeting, biological nanomaterials that can cross the BBB via neurovascular transport channels have also been explored. To overcome the neurotoxicity caused by inorganic nanomaterials, the use of smart nanoagents having both enhanced biocompatibility and effective tumor targeting ability to enhance the efficiency of CDT are systematically summarized. Finally, the advancements in intelligent Fenton-based nanosystems for a multimodal therapeutic approach in addition to CDT are demonstrated. Hopefully, this systematic review will provide a better understanding of Fenton-based CDT and insight into GBM treatment. Full article
(This article belongs to the Special Issue Recent Advances in NIR-II Fluorescence Imaging-Based Cancer Treatment)
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