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Drug- and Ion-Releasing Implants
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Drug- and Ion-Releasing Implants

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Tissue Engineering and Regenerative Medicine".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 1195

Editors

Prof. Dr. Michael D. Roach

E-Mail Website
Guest Editor
Department of Biomedical Materials Science, University of Mississippi Medical Center, Jackson, MS, USA
Interests: implant surface coatings; anodization; additive manufacturing of implant materials; corrosion and corrosion fatigue; failure analysis; implant alloy development
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Amol V. Janorkar

E-Mail Website
Guest Editor
Biomedical Materials Science, School of Dentistry, University of Mississippi Medical Center, Jackson, MS 39216, USA
Interests: synthesis and modification of polymeric biomaterials; tissue engineering; multi-component drug delivery systems; in vitro tissue and disease models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue explores the latest advances in drug- and ion-releasing implants, highlighting innovations in biomaterials, controlled-release mechanisms, and clinical applications. Topics include novel fabrication techniques, bioactive coatings, and the integration of ions for therapeutic modulation into or onto metallic-, ceramic-, and polymeric-based implants. By bringing together interdisciplinary research, this Special Issue aims to advance the development of implants that enhance patient outcomes and redefine the boundaries of biomedical engineering.

Prof. Dr. Michael D. Roach
Prof. Dr. Amol V. Janorkar
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery
  • ion releasing
  • controlled release
  • implant coatings
  • surface modification

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Published Papers (1 paper)

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Research

20 pages, 2967 KB  
Article
Using Citric-Acid-Based Anodization to Form Magnesium-Doped Carbonated Apatite-Containing Oxides on Solid and 3D-Printed Titanium Substrates
by Amisha Parekh, Arunendu Ettuthaiyil Sambasivan, Mikyle Paul, Arash Soltani, Aya Ali, John Tucker, Jonathan W. Pegues, Nima Shamsaei, Amol V. Janorkar and Michael D. Roach
J. Funct. Biomater. 2026, 17(4), 190; https://doi.org/10.3390/jfb17040190 - 14 Apr 2026
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Abstract
With increasing life expectancy and an aging global population, the demand for orthopedic and dental implants is increasing. Recently developed, citric-acid-based anodization processes facilitate the production of more bioactive oxide layers by incorporating important bone minerals such as Ca, P, and Mg and [...] Read more.
With increasing life expectancy and an aging global population, the demand for orthopedic and dental implants is increasing. Recently developed, citric-acid-based anodization processes facilitate the production of more bioactive oxide layers by incorporating important bone minerals such as Ca, P, and Mg and forming bone-like crystalline compounds such as carbonated apatite on titanium implant materials. The primary goal of the present study was to evaluate the applicability of these anodization processes to solid and 3D-printed titanium alloy substrates. The anodized oxides produced on each solid or 3D-printed lattice substrate revealed multi-scaled surface roughness profiles as evidenced by scanning electron microscopy, optical microscopy, and surface roughness analyses. Additionally, each oxide group was shown to incorporate substantial amounts of Ca, P, and Mg bone-mineral dopants and form AB-type carbonated apatite, as shown using a combination of energy-dispersive spectroscopy, X-ray photoelectron spectroscopy, X-ray diffraction, and attenuated total reflectance–Fourier transform infrared spectroscopy analyses. Finally, each oxide group showed sustained Ca, P, and Mg ion release during an inductively coupled plasma spectroscopy dissolution assessment, and demonstrated early apatite-forming ability during simulated body fluid bioactivity testing. The findings of this study show much promise for the applicability of these novel oxide coatings to a wide variety of future titanium implant applications. Full article
(This article belongs to the Special Issue Drug- and Ion-Releasing Implants)
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