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Nanomaterials for Applications in Translation Medicine
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Nanomaterials for Applications in Translation Medicine

A special issue of International Journal of Translational Medicine (ISSN 2673-8937).

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 6943

Special Issue Editor

Prof. Dr. Amol V. Janorkar

E-Mail Website
Guest Editor
Biomedical Materials Science, School of Dentistry, University of Mississippi Medical Center, Jackson, MS 39216, USA
Interests: synthesis and modification of polymeric biomaterials; tissue engineering; multi-component drug delivery systems; in vitro tissue and disease models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanomaterials, defined as having particles or surface features smaller than 100 nm, are gaining prominence in healthcare research. Nanoparticles are being used as drug delivery vehicles to carry a variety of drugs to specific target areas in the body. Nano-featured surfaces have been used as cell culture substrates in vitro. Certain implant surfaces have also been modified to achieve nano-scale features to elicit desirable interactions with the host tissue. While some of the original nanomaterials used carbon nanotubes and metallic nanospheres, recent years have seen the development of nanoparticles of a variety of shapes and a diverse set of base materials (ceramics, synthetic polymers, natural polymers, etc.). Similarly, while many nanomaterials were originally developed for their cytotoxic capability for cancer treatment applications, current research also focuses on more “biocompatible” nanomaterials that can induce tissue growth and induce favorable cell phenotypes. To track this incredible evolution in nanomaterials and their applications, this Special Issue titled “Nanomaterials for Applications in Translation Medicine” invites papers describing novel methods of nanomaterials synthesis, specific characterization techniques that analyze materials at the nanoscale, as well as applications of nanomaterials for drug delivery, in vitro cell culture, and in vivo delivery.

You may share this invitation with your team members and colleagues; co-authors are most welcome.

Please let me know if you and your colleagues are interested in submitting a manuscript for this Special Issue.

Thank you and looking forward to hearing from you.

Prof. Dr. Amol V. Janorkar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Translational Medicine is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterial synthesis
  • drug delivery
  • nanomaterial characterization
  • cell-nanomaterial interaction
  • biomaterials

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Published Papers (3 papers)

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Research

11 pages, 1887 KiB  
Article
Water-Soluble Carbon Nanotube Enhances Gossypol Production in Cotton Cell Suspension Culture
by Sameer Dixit, Akanchha Shukla, Santosh Kumar Upadhyay and Praveen Chandra Verma
Int. J. Transl. Med. 2022, 2(4), 607-617; https://doi.org/10.3390/ijtm2040046 - 5 Dec 2022
Cited by 1 | Viewed by 2086
Abstract
Plant secondary metabolites are well-recognized medicinally important compounds. Gossypol is an important plant secondary metabolite with several medicinal properties. Carbon nanotubes (CNTs) are allotropes of carbon with diverse applicability in chemical, physical, and biological sciences due to their high surface area. The current [...] Read more.
Plant secondary metabolites are well-recognized medicinally important compounds. Gossypol is an important plant secondary metabolite with several medicinal properties. Carbon nanotubes (CNTs) are allotropes of carbon with diverse applicability in chemical, physical, and biological sciences due to their high surface area. The current study demonstrates the enhancement of gossypol production in cotton cell suspension culture in culture media supplemented with water-soluble carbon nanotubes. The fresh and dry weights of cotton cell suspension culture grown in MS media with 20 µg/mL CNTs were, respectively, 1.9 and 2.13 fold higher than in control MS media after one month. The net enhancement of gossypol production in MS media supplemented with 20 µg/mL CNTs was 2.47 fold higher than the control. Confocal and SEM imaging showed the presence CNTs on the cell surface, which mediated the formation of extra channels that resulted in high biomass production in cotton cell suspension culture. The gossypol produced by this cell suspension culture showed antiproliferative activity against the prostate cancer cell line. Thus, this study demonstrated a new method for enhanced gossypol production, which can prove beneficial for the production of other plant-based biological active compounds. Full article
(This article belongs to the Special Issue Nanomaterials for Applications in Translation Medicine)
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15 pages, 2574 KiB  
Article
Characterization of Engineered Cerium Oxide Nanoparticles and Their Effects on Lung and Macrophage Cells
by Michael Bushell, Filip Kunc, Xiaomei Du, Andre Zborowski, Linda J. Johnston and David C. Kennedy
Int. J. Transl. Med. 2022, 2(4), 522-536; https://doi.org/10.3390/ijtm2040039 - 17 Oct 2022
Cited by 1 | Viewed by 2216
Abstract
Cerium oxide nanoparticles are promising materials as novel nanoscale therapeutics and are commonly used materials in industrial processes. Most cytotoxicity studies on cerium oxide nanoparticles are made from in-lab prepared materials making comparison between studies challenging, especially when performed on unique cell lines [...] Read more.
Cerium oxide nanoparticles are promising materials as novel nanoscale therapeutics and are commonly used materials in industrial processes. Most cytotoxicity studies on cerium oxide nanoparticles are made from in-lab prepared materials making comparison between studies challenging, especially when performed on unique cell lines under non-standard conditions. Using commercially available nanoparticles we show that particle stability/agglomeration may be critical in determining the cytotoxicity in some cell lines, while in other cell lines, larger sized primary particles are linked to higher cytotoxicity, contrasting what has been reported in the literature for smaller cerium nanoparticles. To accelerate the development of cerium oxide enabled commercial processes and biomedical innovations, a clearer understanding of the interactions between cerium oxide nanoparticles and cells is needed to better understand their fate in and impact on biological systems. Full article
(This article belongs to the Special Issue Nanomaterials for Applications in Translation Medicine)
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7 pages, 1781 KiB  
Article
Antifungal Activity of Angelica gigas with Enhanced Water Solubility of Decursin and Decursinol Angelate by Hot-Melt Extrusion Technology against Candida albicans
by Suji Ryu, Ha Yeon Lee, Seoul-Hee Nam and Jong-Suep Baek
Int. J. Transl. Med. 2022, 2(4), 515-521; https://doi.org/10.3390/ijtm2040038 - 30 Sep 2022
Cited by 1 | Viewed by 1724
Abstract
Hot-melt extrusion (HME) has been an alternative technique to improve the solubility and bioavailability of active molecules with low water solubility. In this study, HME-Angelica gigas Nakai (AGN) was prepared to increase the aqueous solubility of decursin (D) and decursinol angelate (DA), [...] Read more.
Hot-melt extrusion (HME) has been an alternative technique to improve the solubility and bioavailability of active molecules with low water solubility. In this study, HME-Angelica gigas Nakai (AGN) was prepared to increase the aqueous solubility of decursin (D) and decursinol angelate (DA), the active ingredients of AGN. Compared with unprocessed AGN, HME-AGN showed enhanced water solubility of D and DA. The HME-AGN exhibited improved antioxidant activity by the DPPH radical scavenging method. The antifungal activity was confirmed against Candida albicans (C. albicans). There was a decrease in CFU in the plate treated with the HME-AGN extract compared with the plate treated with the AGN extract, and F2 showed the highest antifungal activity. Full article
(This article belongs to the Special Issue Nanomaterials for Applications in Translation Medicine)
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