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Multimodal Ophthalmic Imaging and Therapeutic Advances in Retinal Diseases: Real-World...
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Multimodal Ophthalmic Imaging and Therapeutic Advances in Retinal Diseases: Real-World Insights and Clinical Outcomes

A special issue of Journal of Clinical & Translational Ophthalmology (ISSN 2813-1053).

Deadline for manuscript submissions: closed (15 June 2025) | Viewed by 825

Special Issue Editors

Dr. Stefano Mercuri

E-Mail Website
Guest Editor
Department of Neurosciences, Psychology, Drug Research, and Child Health, Eye Clinic, University of Florence, AOU Careggi, 50139 Florence, Italy
Interests: retinal imaging; surgical retina; retinal diseases; fluorescein angiography; OCT; OCT-angiography; age-related macular degeneration; retinal dystrophies
Special Issues, Collections and Topics in MDPI journals
Dr. Fabrizio Giansanti

E-Mail Website
Guest Editor
Department of Neurosciences, Psychology, Drug Research, and Child Health, Eye Clinic, University of Florence, AOU Careggi, 50139 Florence, Italy
Interests: surgical retina; medical retina; clinical ophtalmology; phakic intraocular lenses; aphakia; epiretinal membrane; OCT; vitrectomy; dry eye syndromes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, multimodal imaging has become the gold standard in the diagnosis of retinal diseases. Different ocular imaging techniques have increased the accuracy and subclassifications of retinal conditions, allowing for identification of predisposing anatomical factors, specific diagnostic criteria, and prognistic imaging biomarkers to identify the correct diagnosis and predict treatment response. The presence of a specific biomarker can give a hint to the physician to predict disease prognosis and final visual outcomes, allowing them to correctly communicate with the patient and caregivers.

New imaging technologies have given insights in retinal diseases, among which are optical coherence tomography (OCT), OCT-angiography, and adaptive optics imaging.

This Special Issue of the Journal of Clinical and Translational Ophthalmology joint with Journal of Clinical Medicine focuses on the multimodal imaging of retinal diseases with a focus on diagnostic techniques, biomarkers of disease activity, new therapeutic agents, and protocols in real-world settings.

You may choose our Joint Special Issue in Journal of Clinical Medicine.

Dr. Stefano Mercuri
Dr. Fabrizio Giansanti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical & Translational Ophthalmology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • surgical retina
  • medical retina
  • imaging
  • multimodal imaging
  • uveitis
  • OCT

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Published Papers (1 paper)

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Research

13 pages, 1280 KiB  
Article
Seven-Year Outcomes of Aflibercept in Neovascular Age-Related Macular Degeneration in a Teaching Hospital Setting
by Antoine Barloy, Florent Boulanger, Benjamin Jany and Thi Ha Chau Tran
J. Clin. Transl. Ophthalmol. 2025, 3(3), 14; https://doi.org/10.3390/jcto3030014 - 30 Jul 2025
Viewed by 373
Abstract
Background: In clinical practice, visual outcomes with anti-VEGF therapy may be worse than those observed in clinical trials. In this study, we aim to investigate the long-term outcomes of neovascularization treated with intravitreal aflibercept injections (IAI) in a teaching hospital setting. Methods: This [...] Read more.
Background: In clinical practice, visual outcomes with anti-VEGF therapy may be worse than those observed in clinical trials. In this study, we aim to investigate the long-term outcomes of neovascularization treated with intravitreal aflibercept injections (IAI) in a teaching hospital setting. Methods: This is a retrospective, single-center study including 81 nAMD patients (116 eyes), those both newly diagnosed and switched from ranibizumab. All patients had a follow-up duration of at least seven years. Treatment involved three monthly injections followed by either a pro re nata (PRN) or treat and extend regimen. Follow-up care was primarily conducted by training physicians. The primary endpoint was the change in best-corrected visual acuity (BCVA) over seven years. Secondary endpoints included central retinal thickness changes, qualitative OCT parameters, macular atrophy progression, injection frequency, and treatment adherence. Results: Among the 116 eyes, 52 (44.8%) completed the seven-year follow-up. Visual acuity improved by +2.1 letters in the overall population (+6.3 letters in treatment-naive eyes) after the loading phase but gradually declined, resulting in a loss of −12.3 letters at seven years. BCVA remained stable (a loss of fewer than 15 letters) in 57.7% of eyes. Central retinal thickness (CRT) decreased significantly during follow-up in both naive and switcher eyes. Macular atrophy occurred in 94.2% of eyes, progressing from 1.42 mm2 to 8.55 mm2 over seven years (p < 0.001). The mean number of injections was 4.1 ± 1.8 during the first year and 3.7 per year thereafter. Advanced age at diagnosis was a risk factor for loss to follow-up, with bilaterality being a protective factor against loss to follow-up (p < 0.05). Conclusions: This study highlights the challenges faced by a retina clinic in a teaching hospital. Suboptimal functional and anatomical outcomes in real life may derive from insufficient patient information and inconsistent monitoring, which contributes to undertreatment and affects long-term visual outcomes. It also raises concerns about supervision in a teaching hospital which needs to be improved. Full article
(This article belongs to the Special Issue Multimodal Ophthalmic Imaging and Therapeutic Advances in Retinal Diseases: Real-World Insights and Clinical Outcomes)
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