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Multimodal Ophthalmic Imaging and Therapeutic Advances in Retinal Diseases: Real-World Insights and Clinical Outcomes

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: 15 June 2025 | Viewed by 775

Special Issue Editors

Dr. Stefano Mercuri

E-Mail Website
Guest Editor
Department of Neurosciences, Psychology, Drug Research, and Child Health, Eye Clinic, University of Florence, AOU Careggi, 50139 Florence, Italy
Interests: retinal imaging; surgical retina; retinal diseases; fluorescein angiography; OCT; OCT-angiography; age-related macular degeneration; retinal dystrophies
Special Issues, Collections and Topics in MDPI journals
Dr. Fabrizio Giansanti

E-Mail Website
Guest Editor
Department of Neurosciences, Psychology, Drug Research, and Child Health, Eye Clinic, University of Florence, AOU Careggi, 50139 Florence, Italy
Interests: surgical retina; medical retina; clinical ophtalmology; phakic intraocular lenses; aphakia; epiretinal membrane; OCT; vitrectomy; dry eye syndromes
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, multimodal imaging has become the gold standard in the diagnosis of retinal diseases. Different ocular imaging techniques have increased the accuracy and subclassifications of retinal conditions, allowing for identification of predisposing anatomical factors, specific diagnostic criteria, and prognistic imaging biomarkers to identify the correct diagnosis and predict treatment response. The presence of a specific biomarker can give a hint to the physician to predict disease prognosis and final visual outcomes, allowing them to correctly communicate with the patient and caregivers.

New imaging technologies have given insights in retinal diseases, among which are optical coherence tomography (OCT), OCT-angiography, and adaptive optics imaging.

This Special Issue of the Journal of Clinical and Translational Ophthalmology joint with Journal of Clinical Medicine focuses on the multimodal imaging of retinal diseases with a focus on diagnostic techniques, biomarkers of disease activity, new therapeutic agents, and protocols in real-world settings.

You may choose our Joint Special Issue in Journal of Clinical & Translational Ophthalmology.

Dr. Stefano Mercuri
Dr. Fabrizio Giansanti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • surgical retina
  • medical retina
  • imaging
  • multimodal imaging
  • uveitis
  • OCT

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Published Papers (1 paper)

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Research

13 pages, 2166 KiB  
Article
7 Tesla MRI Reveals Brain Structural Abnormalities and Neural Plasticity in RPGR-Related Retinitis Pigmentosa
by Katarzyna Nowomiejska, Katarzyna Baltaziak, Aleksandra Czarnek-Chudzik, Michał Toborek, Anna Niedziałek, Katarzyna Wiśniewska, Mateusz Midura, Robert Rejdak and Radosław Pietura
J. Clin. Med. 2025, 14(5), 1617; https://doi.org/10.3390/jcm14051617 - 27 Feb 2025
Viewed by 497
Abstract
Objectives: The purpose was to quantitatively examine brain structures using 7 Tesla MRI in the presence of visual loss caused by retinitis pigmentosa (RP) related to retinitis pigmentosa GTPase regulator (RPGR) gene pathogenic variants. Methods: Twelve male patients with RP (mean visual acuity [...] Read more.
Objectives: The purpose was to quantitatively examine brain structures using 7 Tesla MRI in the presence of visual loss caused by retinitis pigmentosa (RP) related to retinitis pigmentosa GTPase regulator (RPGR) gene pathogenic variants. Methods: Twelve male patients with RP (mean visual acuity 0.4) related to confirmed RPGR pathogenic variants and fifteen healthy volunteers were examined with 7 Tesla MRI of the brain. Measures of the lateral geniculate nucleus (LGN) volume were performed manually by three independent investigators (radiologists) using ITK-SNAP (Insight Segmentation and Registration Toolkit) software. Other brain structures were evaluated using the open-source automated software package FreeSurfer. Prior to the 7 Tesla MRI, patients underwent an ophthalmic examination and a 1.5 Tesla MRI. Results: The mean LGN volume (right—100 mm3, left—96 mm3) and left lingual gyrus volume (6162 mm3) were significantly lower in RPGR patients in comparison to the control group (129 mm3, 125 mm3, and 7310 mm3, respectively), whilst some brain regions related to other sensory information such as the left isthmus cingulate (3690 mm3) and entorhinal cortex (right—1564 mm3, left 1734 mm3) were significantly or almost significantly higher in the RPGR group than in the control group (2682 mm3, 960 mm3, and 1030 mm3, respectively). Moreover, compared to the control group, the RPGR group’s thalamus-to-LGN ratio was substantially higher. Conclusions: The use of the 7 Tesla MRI revealed numerous structural abnormalities of the visual pathway in patients with RPGR-related RP. The reorganization of the structures of the brain demonstrated in patients with RPGR-related RP reveals a certain degree of plasticity in response to visual loss. These findings may help improve diagnostic and therapeutic strategies for RP patients and contribute to the development of precision medicine. Full article
(This article belongs to the Special Issue Multimodal Ophthalmic Imaging and Therapeutic Advances in Retinal Diseases: Real-World Insights and Clinical Outcomes)
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