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Interventional Cardiology: Recent Advances and Future Perspectives
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Interventional Cardiology: Recent Advances and Future Perspectives

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 25 April 2026 | Viewed by 2740

Special Issue Editors

Dr. Cristina Aurigemma

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Guest Editor
Dipartimento di Scienze Cardiovascolari—CUORE, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
Interests: structural intervention; acute heart failure; acute coronary syndrome
Special Issues, Collections and Topics in MDPI journals
Dr. Luigi Cappannoli

E-Mail Website
Guest Editor
Dipartimento di Scienze Cardiovascolari—CUORE, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
Interests: acute heart failure; chronic heart failure; coronary intervention
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Interventional cardiology has rapidly evolved, offering innovative approaches to diagnosing and treating cardiovascular diseases. Recent advances in percutaneous coronary interventions (PCIs), structural heart interventions, and imaging technologies have significantly improved patient outcomes. The integration of artificial intelligence and novel biomaterials is further shaping the future of personalized cardiovascular care. Transcatheter therapies, including transcatheter aortic valve implantation (TAVI) and mitral valve repair, have expanded treatment options for high-risk patients. In addition, new pharmacological strategies and antithrombotic regimens are continuing to optimize procedural success and long-term safety. Despite these advancements, challenges remain in relation to patient selection, the long-term durability of devices, and managing complex coronary and structural heart disease. This Special Issue will explore the latest developments in interventional cardiology, emerging technologies, and future directions to enhance procedural efficacy and patient-centered care.

Dr. Cristina Aurigemma
Dr. Luigi Cappannoli
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • interventional cardiology
  • percutaneous coronary intervention (PCI)
  • transcatheter aortic valve implantation (TAVI)
  • structural heart disease
  • coronary artery disease
  • imaging and artificial intelligence
  • antithrombotic therapy
  • future technologies in cardiology
  • personalized cardiovascular care
  • minimally invasive interventions

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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9 pages, 259 KB  
Article
Impact of Baseline Atrial Fibrillation on Conduction Disturbances After TAVR: Insights from a Large Cohort Study
by Ziad Arow, Omar Oliva, Laurent Bonfils, Laurent Lepage, Hana Vaknin-Assa, Abid Assali, Didier Tchetche and Nicolas Dumonteil
J. Clin. Med. 2025, 14(21), 7705; https://doi.org/10.3390/jcm14217705 - 30 Oct 2025
Viewed by 399
Abstract
Background: Pre-existing atrial fibrillation (AF) is common among patients undergoing transcatheter aortic valve replacement (TAVR). However, evidence regarding its impact on the risk of permanent pacemaker (PPM) implantation and other conduction disturbances (CDs) after TAVR remains inconsistent. The aim of this study [...] Read more.
Background: Pre-existing atrial fibrillation (AF) is common among patients undergoing transcatheter aortic valve replacement (TAVR). However, evidence regarding its impact on the risk of permanent pacemaker (PPM) implantation and other conduction disturbances (CDs) after TAVR remains inconsistent. The aim of this study was to assess the effect of baseline heart rhythm on the risk of conduction abnormalities following TAVR. Methods: This study included patients with severe AS who underwent TAVR using either balloon-expandable (BEVs) or self-expanding valves (SEVs). The primary endpoint was the incidence of PPM implantation and new or worsening left bundle branch block (LBBB) after TAVR according to baseline rhythm (sinus rhythm vs. AF). Secondary endpoints were predictors of PPM implantation, LBBB, the occurrence of periprocedural stroke, and in-hospital mortality. Results: A total of 5195 TAVR patients were included: 3560 with baseline sinus rhythm and 1635 with baseline AF. PPM implantation was more frequent in patients with AF than in those with sinus rhythm (17% vs. 15%, p = 0.033), whereas new or worsening LBBB was less common (11% vs. 14%, p = 0.026). After adjustment with multivariable logistic regression, these associations were no longer statistically significant (PPM implantation: OR 1.156, 95% CI 0.969–1.379, p = 0.108; new or worsening LBBB: OR 0.826, 95% CI 0.676–1.010, p = 0.062). Independent peri-procedural predictors of PPM implantation included baseline first-degree AV block, pre-procedural RBBB, the use of self-expandable valves, implantation of larger valve sizes (≥23 mm), and the need for valve repositioning. Conclusions: In this large cohort, baseline AF was not associated with an increased risk of PPM implantation or new onset LBBB compared with sinus rhythm. These findings suggest that baseline rhythm alone should not be considered an independent predictor of PPM implantation or CDs following TAVR. Full article
(This article belongs to the Special Issue Interventional Cardiology: Recent Advances and Future Perspectives)
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9 pages, 273 KB  
Article
Suture or Device? A Real-World Analysis of the Closure Strategies in Patients Undergoing LAA Occlusion
by Saif Zako, Kathrin Klein, Asena Öz, Maei Elsobki, Philipp Mourikis, Carolin Helten, David Naguib, Malte Kelm, Tobias Zeus and Amin Polzin
J. Clin. Med. 2025, 14(15), 5245; https://doi.org/10.3390/jcm14155245 - 24 Jul 2025
Viewed by 759
Abstract
Background: Left atrial appendage occlusion (LAAO) is a valuable alternative to long-term anticoagulation in patients with atrial fibrillation (AF) and a high bleeding risk. However, effective vascular closure following large-bore venous access remains a clinical challenge, particularly in patients with multiple comorbidities. [...] Read more.
Background: Left atrial appendage occlusion (LAAO) is a valuable alternative to long-term anticoagulation in patients with atrial fibrillation (AF) and a high bleeding risk. However, effective vascular closure following large-bore venous access remains a clinical challenge, particularly in patients with multiple comorbidities. This study compares two venous closure techniques—Z-sutures and the suture-mediated ProGlide™ device—regarding their safety and efficacy in patients undergoing LAAO. Methods: We conducted a single-center observational study including 163 patients treated with LAAO between 2021 and 2024. Closure was achieved via a Z-suture (n = 126) or the ProGlide™ (n = 37) based on operator preference. The primary endpoint was clinically relevant bleeding (BARC ≥ 2). The secondary endpoints included 30-day mortality and hospital stay duration. Results: The Z-suture group included older and more comorbid patients. Despite these differences, the bleeding rates were comparable between groups. Clinically relevant bleeding was infrequent (Z-suture: 12.6%; ProGlide™: 13.5%). No 30-day deaths occurred in either group, and their hospital stay durations were similar. Conclusions: Both the Z-suture and ProGlide™ techniques demonstrated comparable safety and efficacy. Due to their simplicity and potential cost advantage, Z-sutures may be a practical alternative in routine care for high-risk patients. Full article
(This article belongs to the Special Issue Interventional Cardiology: Recent Advances and Future Perspectives)
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Review

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20 pages, 2578 KB  
Review
TAVI for Bicuspid Aortic Valve: Addressing Technical Challenges and Optimizing Outcomes
by Donato Antonio Paglianiti, Cristina Aurigemma, Marco Busco, Luigi Cappannoli, Francesco Bianchini, Enrico Romagnoli, Mattia Lunardi, Francesco Fracassi, Lazzaro Paraggio, Antonino Buffon, Rocco Antonio Montone, Antonio Maria Leone, Carlo Trani and Francesco Burzotta
J. Clin. Med. 2025, 14(21), 7860; https://doi.org/10.3390/jcm14217860 - 5 Nov 2025
Viewed by 942
Abstract
Bicuspid aortic valve (BAV) is the most common congenital valvular anomaly, affecting roughly 1–2% of the population and predisposing to premature aortic stenosis and thoracic aortopathy. Surgical aortic valve replacement (SAVR) remains the standard therapy, while transcatheter aortic valve implantation (TAVI) is increasingly [...] Read more.
Bicuspid aortic valve (BAV) is the most common congenital valvular anomaly, affecting roughly 1–2% of the population and predisposing to premature aortic stenosis and thoracic aortopathy. Surgical aortic valve replacement (SAVR) remains the standard therapy, while transcatheter aortic valve implantation (TAVI) is increasingly adopted across a broader range of risk profiles due to accumulating evidence and advancements in device technology. Observational registries and early trial data indicate that TAVI is technically feasible in selected BAV anatomies, with device-success rates exceeding 90%. Nonetheless, bicuspid morphology is still technically demanding, with several possible pitfalls during transcatheter procedure and pre-procedural planning compared with tricuspid valve. The rates of moderate-to-severe paravalvular leak (PVL), permanent pacemaker implantation (PPI), and annular complications remain high, especially in the presence of extensive calcifications with raphe or tapered roots, underscoring the importance of meticulous multimodality imaging, dedicated sizing algorithms, and device-specific strategies. Long-term durability signals are encouraging but remain limited, underlining the need for prospective trials with extended follow-up. This review summarizes current knowledge on BAV anatomy and its management, exploring the available evidence supporting the role of transcatheter approach in this challenging and unique scenario. Full article
(This article belongs to the Special Issue Interventional Cardiology: Recent Advances and Future Perspectives)
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