Integration of Clinical and Molecular Studies in Understanding the Pathogenesis of Hearing Loss: From Cause to Cure

Dear Colleagues,

Hearing loss affects at least 1 in 1000 newborns, is a major cause of disability in children and adults, and markedly affects quality of life. Inner ear malfunction, also called sensorineural hearing loss, is caused by damage to the sensory cells and/or nerve fibers of the inner ear. Genetic alterations, exposure to drugs or noise, as well as aging are among the causes of sensorineural hearing loss. Moreover, structures of the central hearing system may also be affected, potentially contributing to hearing loss. An accurate clinical appraisal plays a fundamental role in assisting patients with hearing loss. At the same time, identification of the precise molecular mechanism of hearing loss is essential to develop novel therapies. Therefore, a close integration of clinical and molecular studies is necessary to progress from cause to cure. In research-based medical care, clinical observations stimulate research, which paves the way for novel therapeutic strategies and eventually leads back to the bedside for their implementation.

The scope of this Special Issue is to collect and contribute to the dissemination of novel insights on the causes of hearing loss. Clinical studies must be accompanied by evidence illuminating the molecular mechanism of the disease and suggesting novel options and targets for therapy. The submission of original articles is encouraged; review articles as well as commentaries will also be accepted. Please note that case studies, case series, study protocols and mini reviews will not be considered.

Dr. Silvia Dossena
Dr. Sebastian Roesch
Guest Editors

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