Importance of Genetic Variants for the Hepatic Metabolism of Xenobiotics
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 5612
Special Issue Editor
Interests: molecular pharmacology; pharmacogenetics; personalized medicine; drug development; pharmacogenomics; liver diseases
Special Issue Information
Dear Colleagues,
Inter-individual differences in drug response and toxicity are major issues for pharmacological therapy. Genetic variability in genes involved in hepatic metabolism constitutes a major driving force behind differences in drug pharmacokinetics. Seminal research has unraveled a plethora of associations between polymorphisms in phase 1 and phase 2 drug-metabolizing genes, as well as drug transporters with differences in drug disposition. However, a substantial fraction of the heritable variability in drug response remains unexplained. Importantly, the increasing availability of sequencing technologies has opened new avenues for pharmacogenetic studies of liver metabolism with promising prospects for the individualization of therapy.
This Special Issue aims to provide the latest research on the genetics of hepatic drug metabolism. To this end, we invite original research articles, meta-analyses, and reviews that focus on associations between genetic variability in hepatic genes and drug metabolism phenotypes. Furthermore, we welcome socioeconomic analyses of genotype-guided prescription and contributions that provide novel concepts and perspectives for the implementation of pharmacogenomics into clinical care, including evaluations of emerging technologies for point-of-care diagnostics, biobanking, as well as methods that facilitate analyses of pharmacogenomic complexity.
Dr. Volker M. Lauschke
Guest Editor
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Keywords
- pharmacogenomics
- personalized medicine
- precision medicine
- public health
- cytochrome P450
- drug metabolism
- companion diagnostics
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