Management of Endotoxemia and Sepsis

Dear Colleagues,

Endotoxin is considered a key signaling molecule in the pathogenesis of shock—the higher the endotoxin level, the more severe the clinical symptoms. The dysfunction of vital organs and coagulation abnormalities often lead to the development of organ failure and death. Therefore, a therapy aimed at reducing the level of endotoxin may improve the clinical condition of patients and reduce mortality rates. In patients with sepsis, anti-endotoxin drug therapies have failed to show significant clinical benefits, and studies on the elimination of circulating endotoxins using extracorporeal methods such as adsorbent-based hemoperfusion or continuous renal replacement therapy have found inconsistent results. Therefore, studies on novel therapeutic strategies of neutralizing and eliminating endotoxins and accurate methods of endotoxin detection are vitally important for the future management of critically ill patients. In this Special Issue of the Journal of Clinical Medicine, we will discuss the etiology, clinical manifestations, diagnostic, and optimal strategies that can reduce endotoxemia and improve organ function. Preclinical research based on animal or human models as well as clinical studies including patients are welcome for submission.

Dr. Barbara Adamik
Guest Editor

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