Advances in Ischemic/Reperfusion Injury in Acute Myocardial Infarction

Dear Colleagues,

acute myocardial infarction is associated with high rates of morbidity and mortality. Timely reperfusion is a mainstay for myocardial salvage and infarct size limitation, however, the reperfusion itself may trigger a lethal tissue injury which is known as myocardial ischemia/reperfusion injury. Myocardial reperfusion injury may substantially limit the benefit of reperfusion and negatively impact on final infarct size and clinical outcome.

In the past decades, remarkable advances were made in the understanding of the molecular pathways of myocardial reperfusion injury, this led to the development of strategies, drugs and also devices targeting reperfusion injury, aiming to limit the impact of reperfusion injury on infarct size. Altough favourable results in pre-clinical and animal studies, many novel treamens failed in the translational pathway and still a strategy to effectively limit the reperfusion injury during primary coronary interventions is lacking.

In this special issue of the Journal of Clinical Medicine will focus on presenting results of pre-clinical and clinical studies abour myocardial ischemia/reperfusion injury, with a particular emphasis on translational models and strategies that may applied in clinical setting during primary coronary interventions.

Dr. Gabriele Crimi
Guest Editor

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