Mechanical Unloading of the Left Ventricle before Coronary Reperfusion in Preclinical Models of Myocardial Infarction without Cardiogenic Shock: A Meta-Analysis
Abstract
:1. Introduction
2. Methods
2.1. Study Selection, Eligibility Criteria and Risk of Bias
2.2. Endpoint Definitions
2.3. Statistical Analysis
3. Results
4. Discussion
5. Limitations
6. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Study | Animals | Method of Ischemia | Protocol of Ischemia | Time of MCS Activation | MCS | Delayed Reperfusion | IS Assessment |
---|---|---|---|---|---|---|---|
Achour 2005 [17] | Mongrel dogs | LAD ligation | Ischemia: 120 min Reperfusion: 240 min | Last 15 min of ischemia | TV LVAD | No | Histopathology (TTC staining) |
Briceno 2019 [18] | Yorkshire swine | Balloon inflation into the LAD | Ischemia: 120 min Reperfusion: 180 min | Last 30 min of ischemia | Impella CP | No | Histopathology (TTC staining) |
Esposito 2018 [5] | Yorkshire swine | Stent inflation into the LAD | Ischemia: 90 min (control arm) vs. 120 min (unloading arm)Reperfusion: 120 min | Last 30 min of ischemia | Impella CP | Yes (30 min) | Histopathology (TTC staining) |
Kapur 2015 [20] | Yorkshire swine | Stent inflation into the LAD | Ischemia: 90 min (control arm) vs. 150 min Reperfusion: 120 min | Last 60 min of ischemia | Impella CP | Yes (60 min) | Histopathology (TTC staining) |
LeDoux 2008 [22] | Yorkshire swine | LAD ligation | Ischemia: 60 min Reperfusion: 240 min | Last 15 min of ischemia | IABP | No | Histopathology (TTC staining) |
Meyns 2003 [23] | Dorset sheep | Ligation of the two major diagonal branches of the LAD | Ischemia: 60 min Reperfusion: 120 min | From the onset if ischemia | Impella LV | No | Histopathology (TTC staining) |
Catinella 1983 [19] | Mongrel dogs | LAD ligation | Ischemia: 240 min Reperfusion: NA | After 15 min of ischemia | LA-FA bypass | No | Histopathology (TTC staining) |
Ko 2020 [21] | Yorkshire swine | Ligation of the LAD | Ischemia: 60 min (control arm) vs. 90 min (unloading arm)Reperfusion: 120 min | Last 30 min of ischemia | Impella CP | Yes (30 min) | Histopathology (TTC staining) |
Yoshitake 2012 [26] | Landrace, Large White, and Duroc (LWD) swine | Ligation of the LAD | Ischemia: 120 min Reperfusion: 240 min | Last 30 min of ischemia | Impella LD | No | Histopathology (TTC staining) |
Sunagawa 2018 [24] | Mongrel dogs | Ligation of the left circumflex | Ischemia: 180 min Reperfusion: 180 min | Last 120 min of ischemia | Impella CP | No | Histopathology (TTC staining) |
Tamareille 2008 [25] | Yorkshire swine | Ligation of the LAD (distal third) | Ischemia: 60 minReperfusion: 240 min | Last 15 min of ischemia | A-Med LVAD | No | Histopathology (TTC staining) |
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Benenati, S.; Crimi, G.; Macchione, A.; Giachero, C.; Pescetelli, F.; Balbi, M.; Porto, I.; Vercellino, M. Mechanical Unloading of the Left Ventricle before Coronary Reperfusion in Preclinical Models of Myocardial Infarction without Cardiogenic Shock: A Meta-Analysis. J. Clin. Med. 2022, 11, 4913. https://doi.org/10.3390/jcm11164913
Benenati S, Crimi G, Macchione A, Giachero C, Pescetelli F, Balbi M, Porto I, Vercellino M. Mechanical Unloading of the Left Ventricle before Coronary Reperfusion in Preclinical Models of Myocardial Infarction without Cardiogenic Shock: A Meta-Analysis. Journal of Clinical Medicine. 2022; 11(16):4913. https://doi.org/10.3390/jcm11164913
Chicago/Turabian StyleBenenati, Stefano, Gabriele Crimi, Andrea Macchione, Corinna Giachero, Fabio Pescetelli, Manrico Balbi, Italo Porto, and Matteo Vercellino. 2022. "Mechanical Unloading of the Left Ventricle before Coronary Reperfusion in Preclinical Models of Myocardial Infarction without Cardiogenic Shock: A Meta-Analysis" Journal of Clinical Medicine 11, no. 16: 4913. https://doi.org/10.3390/jcm11164913
APA StyleBenenati, S., Crimi, G., Macchione, A., Giachero, C., Pescetelli, F., Balbi, M., Porto, I., & Vercellino, M. (2022). Mechanical Unloading of the Left Ventricle before Coronary Reperfusion in Preclinical Models of Myocardial Infarction without Cardiogenic Shock: A Meta-Analysis. Journal of Clinical Medicine, 11(16), 4913. https://doi.org/10.3390/jcm11164913