Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.2
3.0
Journals
JCM
Special Issues
Clinical Advances in the Diagnosis and Treatment of Glaucoma and...
jcm-logo
Submit to JCM Review for JCM Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Clinical Advances in the Diagnosis and Treatment of Glaucoma and Ocular Hypertension

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 1162

Special Issue Editor

Prof. Dr. Paolo Fogagnolo

E-Mail Website
Guest Editor
Department of Health Sciences, Università degli Studi di Milano, 20122 Milan, Italy
Interests: cornea; ocular surface; cataract; glaucoma; refractive surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the last few years, the diagnosis of glaucoma has been significantly modified by the clinical introduction of innovative devices. The use of new sophisticated statistical models pursues the early detection of progression at any stage of the disease. Very recently, the first steps toward the integration of structural and functional data have been accomplished. There is increased awareness of progression at any stage of the disease by integrating structural and functional data. There is increased awareness of the importance of limiting ocular surface damage induced by treatments in order to achieve adequate adherence and preserve the quality of life in glaucoma patients. New medications are now available, and neuroprotection is frequently used as a complementary treatment for intraocular pressure reduction. Finally, the recent clinical introduction of several devices for minimally invasive glaucoma surgery has strongly modified the frequency and time at which patients are allocated to surgery. Following these innovations and despite the availability of specific guidelines, decision-making processes for glaucoma patients have become more complex, also due to increased attention to socioeconomic burdens and cost effectiveness analyses.

In this Special Issue, we seek to outline new advances in the glaucoma field, focusing on strategies to improve the clinical management of our patients.

Prof. Dr. Paolo Fogagnolo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glaucoma
  • cornea
  • ocular surface
  • quality of life
  • treatment of glaucoma
  • progression
  • intraocular pressure

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

24 pages, 3212 KiB  
Article
Association of Inflammatory and Ischemic Markers with Posterior Segment Parameters in Pseudoexfoliation Syndrome and Glaucoma
by Muhammed Fatih Satilmaz, Feyzahan Uzun, Hüseyin Findik, Mehtap Atak, Muhammet Kaim, Murat Okutucu and Mehmet Gökhan Aslan
J. Clin. Med. 2025, 14(11), 3833; https://doi.org/10.3390/jcm14113833 - 29 May 2025
Viewed by 309
Abstract
Objective: This study aimed to investigate the structural, vascular, and biochemical alterations in patients with pseudoexfoliation syndrome (PES) and pseudoexfoliative glaucoma (PXG) and to evaluate the associations between serum biomarkers, the retinal nerve fiber layer (RNFL), choroidal thickness (CT), and vessel density (VD) [...] Read more.
Objective: This study aimed to investigate the structural, vascular, and biochemical alterations in patients with pseudoexfoliation syndrome (PES) and pseudoexfoliative glaucoma (PXG) and to evaluate the associations between serum biomarkers, the retinal nerve fiber layer (RNFL), choroidal thickness (CT), and vessel density (VD) in these groups. Methods: All subjects underwent spectral-domain optical coherence tomography (SD-OCT) and OCT angiography (OCTA) to assess RNFL thickness, CT, and VD. Serum levels of inflammatory and oxidative stress biomarkers—including malondialdehyde (MDA), glutathione (GSH), interleukin-6 (IL-6), nitric oxide (NO), inducible NO synthase (iNOS), galectin-3, and SCUBE-1—were analyzed, and regression and ROC curve analyses were performed to evaluate predictive value and diagnostic performance. Results: A total of 80 patients were included and are listed as follows: 25 controls, 30 with PES, and 25 with PXG. There were no significant differences among groups in terms of age or gender. RNFL thickness, CT, and VD were significantly reduced in the PXG group compared to the PES and control groups (p < 0.001). PXG patients showed the most pronounced reductions in both peripapillary and macular CT, as well as superficial and deep VD. Serum iNOS, SCUBE-1, galectin-3, and MDA levels were significantly elevated in PXG, while GSH levels were lower (p < 0.001); NO levels showed no significant differences. In the PES and PXG groups, several ocular parameters correlated significantly with serum biomarkers, particularly iNOS, MDA, and GSH. Regression analysis in PXG patients identified iNOS and MDA as significant predictors of RNFL thickness and VD. ROC analysis demonstrated that MDA and GSH exhibited the highest diagnostic accuracy among the tested biomarkers for distinguishing PXG patients from controls. Conclusions: PXG is associated with significant structural, vascular, and biochemical alterations, including reduced RNFL thickness, choroidal thinning, and decreased VD. Altered serum levels of MDA and GSH were significantly associated with these ocular changes and demonstrated the highest diagnostic accuracy among the biomarkers evaluated. These findings support their potential utility as non-invasive biomarkers for distinguishing PXG from PES and healthy controls and for monitoring disease progression. Full article
(This article belongs to the Special Issue Clinical Advances in the Diagnosis and Treatment of Glaucoma and Ocular Hypertension)
►▼ Show Figures

Figure 1

11 pages, 865 KiB  
Article
Kahook Dual Blade Goniotomy Outcomes in the Underserved Dominican Republic Black and Afro-Latinx Population
by Cristos Ifantides, Hernan Bejar, Jennifer Patnaik, Erin Sieck, Mina Pantcheva, Cara Capitena Young, Margarita Arbaje and William McCollum
J. Clin. Med. 2025, 14(7), 2201; https://doi.org/10.3390/jcm14072201 - 24 Mar 2025
Viewed by 515
Abstract
Background/Objectives: Black and Afro-Latinx communities have a higher propensity for more-severe glaucoma at a younger age. This study aimed to use the Kahook Dual Blade (KDB) to treat all glaucoma subtypes and severity levels in this historically underserved community. Materials and Methods: This [...] Read more.
Background/Objectives: Black and Afro-Latinx communities have a higher propensity for more-severe glaucoma at a younger age. This study aimed to use the Kahook Dual Blade (KDB) to treat all glaucoma subtypes and severity levels in this historically underserved community. Materials and Methods: This study involved a retrospective analysis of surgical case records, with follow-up through 20 months. The subjects were glaucoma patients at Hospital Elias Santana in Santo Domingo, Dominican Republic. Inclusion criteria were age >18 years and a minimum follow-up of 1 year after surgery. All glaucoma subtypes and disease severities were included, including previous glaucoma procedures. Sequential patients undergoing KDB goniotomy alone or in combination with phacoemulsification cataract surgery were assessed. IOP data and number of medications were collected at specific time points: baseline, postoperative day 1, postoperative week 1, and postoperative months 1, 3, 6, 12, 16, and 20. Surgical outcome was determined using IOP and number of medications. Success was defined as either a 20% or more reduction in IOP or a decrease in at least one topical therapy. Recorded postoperative complications were hyphema, ocular hypertension, and need for additional glaucoma surgery. Results: A total of 90 eyes from 90 patients were included. A total of 100% of the patient population was Black or Afro-Latinx. The most common glaucoma subtype was primary open-angle (76.7%). Most of the eyes had severe glaucoma (53.3%). The mean preoperative baseline IOP was 20.5 mmHg. The mean postoperative IOP from all time points ranged from 12.9 to 13.5 mmHg (all time points were significantly lower than baseline IOP, p < 0.0001). A mean reduction in IOP percent of at least 31.5% was seen at every time point. There was a mean reduction of two medications by postoperative month 20. Surgical success was achieved in 95.6% of patients at postoperative month 1 and remained high throughout the study period (95.4% at month 20). Conclusions: KDB goniotomy achieved successful IOP and medication reduction across all levels of glaucoma severity. Surgical success rates were maintained to 20 months. While MIGS has historically been used as an intervention in mild-to-moderate glaucoma, our study results show that the KDB can play a significant role in all stages of glaucoma, including severe. MIGS should be considered as a favorable intervention in all disease severities in Black and Afro-Latinx communities around the world. Full article
(This article belongs to the Special Issue Clinical Advances in the Diagnosis and Treatment of Glaucoma and Ocular Hypertension)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop