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New Insights into Corneal Disease and Transplantation
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New Insights into Corneal Disease and Transplantation

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: closed (30 June 2025) | Viewed by 223

Special Issue Editor

Dr. Cristina Bovone

E-Mail Website
Guest Editor
1. Department of Environmental Sciences and Prevention, University of Ferrara, Ferrara, Italy
2. Department of Ophthalmology, Ospedali Privati Forlì "Villa Igea", Forlì, Italy
Interests: cornea; ophthalmology; keratoplasty; anterior segment surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue represents an opportunity for ophthalmologists to publish their innovative works focused on the recent advances into corneal disease and transplantation. Potential areas of interest include, but are not limited to: lamellar keratoplasty, high-tech intraoperative tools, machine learning and artificial intelligence, and novel surgical techniques. I have the pleasure to invite you to submit your work for consideration in this Special Issue entitled "New Insights into Corneal Disease and Transplantation". Original research articles (clinical research), reviews, and interesting images are welcome. All papers will be fully open access upon publication after peer review.

Dr. Cristina Bovone
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lamellar keratoplasty
  • DSAEK
  • DMEK
  • DALK
  • keratoconus
  • corneal dystrophies
  • bullous keratopathy
  • corneal infection
  • anterior segment-OCT

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Review

16 pages, 1291 KiB  
Review
Pellucid Marginal Degeneration: A Comprehensive Review of Pathophysiology, Diagnosis, and Management Strategies
by Michael Tsatsos, Konstantina Koulotsiou, Ioannis Giachos, Ioannis Tsinopoulos and Nikolaos Ziakas
J. Clin. Med. 2025, 14(15), 5178; https://doi.org/10.3390/jcm14155178 - 22 Jul 2025
Abstract
Purpose: Pellucid Marginal Degeneration (PMD) is a rare ectatic corneal disorder characterized by inferior peripheral thinning and significant irregular astigmatism. Despite its clinical similarities to keratoconus, PMD presents unique diagnostic and therapeutic challenges. This review aims to provide a comprehensive update on the [...] Read more.
Purpose: Pellucid Marginal Degeneration (PMD) is a rare ectatic corneal disorder characterized by inferior peripheral thinning and significant irregular astigmatism. Despite its clinical similarities to keratoconus, PMD presents unique diagnostic and therapeutic challenges. This review aims to provide a comprehensive update on the pathophysiology, clinical features, diagnostic approaches, and management strategies for PMD, emphasizing the latest advancements in treatment options. Methods: A systematic literature search was performed in MEDLINE (via PubMed), Google Scholar, and Scopus up to February 2025 using the terms: “pellucid marginal degeneration,” “PMD,” “ectatic corneal disorders,” “keratoplasty in PMD,” “corneal cross-linking in PMD,” “ICRS in PMD,” “toric IOL PMD” and their Boolean combinations (AND/OR). The search was restricted to English-language studies involving human subjects, including case reports, case series, retrospective studies, clinical trials, and systematic reviews. A total of 76 studies met the inclusion criteria addressing treatment outcomes in PMD. Results: PMD is characterized by a crescent-shaped band of inferior corneal thinning, leading to high irregular astigmatism and reduced visual acuity. Diagnosis relies on advanced imaging techniques such as Scheimpflug-based corneal tomography, which reveals the characteristic “crab-claw” pattern. Conservative management includes rigid gas-permeable (RGP) lenses and scleral lenses, which provide effective visual rehabilitation in mild to moderate cases. Surgical options, such as CXL, ICRS, and toric IOLs, are reserved for advanced cases, with varying degrees of success. Newer techniques such as CAIRS, employing donor tissue instead of synthetic rings, show promising outcomes in corneal remodeling with potentially improved biocompatibility. Penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK) remain definitive treatments for severe PMD, though they are associated with significant risks, including graft rejection and postoperative astigmatism. Conclusions: PMD is a complex and progressive corneal disorder that requires a tailored approach to management. Early diagnosis and intervention are critical to optimizing visual outcomes. While conservative measures are effective in mild cases, surgical interventions offer promising results for advanced disease. Further research is needed to refine treatment protocols and improve long-term outcomes for patients with PMD. Full article
(This article belongs to the Special Issue New Insights into Corneal Disease and Transplantation)
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