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Assisted Reproductive Technology: Recent Developments and Future Perspectives
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Assisted Reproductive Technology: Recent Developments and Future Perspectives

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Reproductive Medicine & Andrology".

Deadline for manuscript submissions: closed (10 February 2025) | Viewed by 646

Special Issue Editors

Dr. Hiva Alipour

E-Mail Website
Guest Editor
Regenerative Medicine, Department of Health Science and Technology, Aalborg University, 9260 Gistrup, Denmark
Interests: male infertility, assisted teproductive technology; reproductive biology; regenerative and reproductive Medicine
Prof. Dr. Ole Bjarne Christiansen

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Aalborg University Hospital, Reberbansgade, DK-9000 Aalborg, Denmark
Interests: recurrent pregnancy loss; reproductive immunology; recurrent miscarriage
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ulrik Schiøler Kesmodel

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Aalborg University Hospital, Reberbansgade, DK-9000 Aalborg, Denmark
Interests: epidemiology; gynecology and obstetrics; reproduction and fertility; endometriosis

Special Issue Information

Dear Colleagues,

Fertility treatments have undergone a transformative shift since the introduction of assisted reproductive technology (ART), and the rapid evolution of ART over the last few decades stands as a remarkable achievement in restorative medicine on the global scale. Assisted reproduction remains a dynamic and continually evolving field characterized by consistently refined protocols, enhanced success rates, and the emergence of innovative technologies, continuously improving the efficacy and accessibility of assisted conception and reproductive interventions.

This Special Issue focuses on the new trends, advancements, and innovations in ART techniques and procedures, encompassing various aspects, including testicular sperm retrieval, ovulation induction, sperm function and quality assessment, oocyte quality assessment, in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), enhanced embryo selection techniques, preimplantation genetic testing (PGT), and recurrent pregnancy loss (RPL). Additionally, this Special Issue explores scientific breakthroughs shedding light on reproductive physiology, pathophysiology, endocrinology, and hormonal regulation, all of which can significantly affect ART’s outcomes. Furthermore, it is timely and relevant to examine the current and prospective roles of artificial intelligence (AI) in shaping the landscape of ART.

Dr. Hiva Alipour
Prof. Dr. Ole Bjarne Christiansen
Prof. Dr. Ulrik Schiøler Kesmodel
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • assisted reproductive technology (ART)
  • infertility
  • recurrent miscarriage
  • selection techniques
  • artificial intelligence

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Published Papers (1 paper)

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22 pages, 3237 KiB  
Systematic Review
Oral Dydrogesterone Versus Vaginal Progesterone for Luteal Phase Support in Frozen–Thawed Embryo Transfer Cycles: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
by Konstantinos Stavridis, Dimitrios Balafoutas, Theodoros Kalampokas, Vassiliki Benetou, Evangelia Samoli, Nikolaos Vlahos and Maria-Iosifina Kasdagli
J. Clin. Med. 2025, 14(9), 3238; https://doi.org/10.3390/jcm14093238 - 7 May 2025
Viewed by 224
Abstract
Background/Objectives: Until recently, oral dydrogesterone has only been established in fresh in vitro fertilization (IVF) cycles, whereas its role in luteal phase support (LPS) for frozen embryo transfer (FET) cycles remains unclear. The aim of this study is to determine whether oral [...] Read more.
Background/Objectives: Until recently, oral dydrogesterone has only been established in fresh in vitro fertilization (IVF) cycles, whereas its role in luteal phase support (LPS) for frozen embryo transfer (FET) cycles remains unclear. The aim of this study is to determine whether oral dydrogesterone as LPS in FET cycles results in pregnancy rates comparable to vaginal progesterone, focusing primarily on ongoing pregnancy rates, but also on clinical pregnancy, miscarriage, and live birth rates. Methods: The study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Five databases (Embase, MEDLINE®, APA PsycInfo, Global Health, and HMIC) and two additional sources were searched from inception to November 28, 2024. Only randomized controlled trials (RCTs) were included. A common effects model combined risk estimates, and heterogeneity was assessed using I2. Study quality was evaluated with Risk of Bias 2 (RoB2), and evidence certainty was graded using GRADE. Results: Overall, five RCTs with a total of 636 women were included in the meta-analysis. The comparison between oral dydrogesterone and vaginal progesterone for LPS did not yield significant differences for any of the outcomes studied. For ongoing pregnancies, the pooled odds ratio (OR) was 0.90 (95% CI: 0.59–1.35), with no heterogeneity (I2 = 8.7%). For miscarriage events, the OR was 1.41 (95% CI: 0.63–3.13, I2 = 0). For clinical pregnancies, the OR was 0.94 (95% CI: 0.62–1.42, I2 = 49.2%), with heterogeneity attributed to dosage. For live births, the pooled OR was 1.08 (95% CI: 0.67–1.75, I2 = 0%). Two studies were assessed as high risk of bias, two as low risk, and one as moderate. The GRADE assessment indicated low to moderate certainty of evidence. Conclusions: Oral dydrogesterone and vaginal progesterone yield comparable reproductive outcomes for LPS in FET cycles. Given its ease of administration, dydrogesterone may serve as a viable alternative in future FET protocols. However, further RCTs are needed to assess its efficacy against other progesterone administration routes. Full article
(This article belongs to the Special Issue Assisted Reproductive Technology: Recent Developments and Future Perspectives)
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