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New Perspective of Oral and Maxillo-Facial Surgery
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New Perspective of Oral and Maxillo-Facial Surgery

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1204

Special Issue Editors

Dr. Valentino Vellone

E-Mail Website
Guest Editor
Department of Life Science, Health, and Health Professions, LINK Campus University, Via del Casale di San Pio V, 44, 00165 Rome, Italy
Interests: oral and maxillofacial surgery; orthognathic surgery; oral surgery; TMJ disorders; TMJ surgery; craniofacial mal-formations; 3D printing custom-made
Dr. Umberto Committeri

E-Mail Website
Guest Editor
Maxillofacial Surgery Unit, Santa Maria Hospital, 93455 Terni, Italy
Interests: oral and maxillofacial surgery; orthognathic surgery; minimally invasive surgery; artificial Intelligence; CAD-CAM; endoscopic surgery; head-neck oncology; 3D printing custom-made
Prof. Dr. Alessandra Lucchese

E-Mail Website
Guest Editor
1. Department of Orthodontics, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, 20123 Milan, Italy
2. Department of Life Sciences, Health and Healthcare Professions, Link Campus University, 00165 Rome, Italy
Interests: diagnosis and treatment plan in orthodontics of II and III class malocclusions; maxillo-facial surgery; sleep apnea syndrome; oral microbiome; diagnostic and therapeutic technologies in the orofacial field from childhood to adulthood; orthodontic fixed appliances; invisalign appliances; interceptive appliances

Special Issue Information

Dear Colleagues,

Oral and maxillofacial surgery is undergoing a paradigm shift, driven by rapid advancements in artificial intelligence (AI), deep and machine learning, and next-generation surgical technologies. The integration of these innovations with minimally invasive procedures, CAD-CAM systems, 3D printing, and patient-specific custom-made surgical solutions is reshaping the field, enabling unprecedented precision, efficiency, and personalization in surgical planning and execution.

This Special Issue aims to showcase groundbreaking research and cutting-edge developments that are revolutionizing oral and maxillofacial surgery. Topics of interest include, but are not limited to:

  • AI-Driven Innovations:
    • Machine learning algorithms for automated diagnosis, risk assessment, and treatment planning
    • AI-powered predictive modeling for surgical outcomes and complications
    • Deep learning applications in medical imaging, including segmentation, classification, and anomaly detection
    • AI-assisted robotic surgery and real-time intraoperative decision support
  • Advanced Surgical Technologies and Digital Workflows:
    • CAD-CAM and in-house custom-made surgical solutions for patient-specific implants, prosthetics, and anatomical models
    • 3D printing applications for personalized bone grafts, soft tissue scaffolds, and surgical guides
    • Virtual surgical planning (VSP) and augmented reality (AR) in preoperative simulations and intraoperative navigation
    • Integration of computational biomechanics and digital twin technology for precision surgery
  • Minimally Invasive and Regenerative Approaches:
    • Robotics and endoscopic techniques for less invasive interventions
    • AI-optimized strategies for accelerating tissue healing and regeneration
    • Bioengineered scaffolds and tissue-engineered constructs enhanced by machine learning algorithms
    • Advanced biomaterials for improved osseointegration and functional restoration

This Special Issue encourages multidisciplinary collaborations between surgeons, bioengineers, data scientists, and computational researchers to bridge the gap between cutting-edge technology and clinical application. We welcome original research, systematic reviews, and clinical trials that focus on the translational impact of these innovations, aiming to redefine standards in patient care.

By bringing together global expertise, this Special Issue will serve as a platform for transformative advancements, fostering the next generation of precision-driven, AI-enhanced, and patient-centered surgical solutions.

Dr. Valentino Vellone
Dr. Umberto Committeri
Prof. Dr. Alessandra Lucchese
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • maxillofacial surgery
  • esthetic surgery
  • orthognatic surgery
  • TMJ disorders
  • TMJ surgery
  • dental implant surgery
  • 3D imaging
  • printing applications
  • tissue engineering
  • personalized treatment planning
  • artificial intelligence
  • squamous cell carcinoma
  • skin tumors
  • plastic and reconstructive surgery
  • head and neck surgery
  • ENT surgery

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

11 pages, 783 KiB  
Article
Effects of the Application of an Oxygen-Enriched Oil-Based Dressing (NovoX®-Drop) After Extraction of Impacted Lower Third Molars: A Randomized Controlled Study
by Valeria Mitro, Francesco Giovacchini, Massimiliano Gilli, Gabriele Monarchi, Angela Rosa Caso, Antonio Bimonte, Guido Lombardo and Antonio Tullio
J. Clin. Med. 2025, 14(14), 4986; https://doi.org/10.3390/jcm14144986 - 15 Jul 2025
Viewed by 100
Abstract
Objective: Lower third impacted molar extraction, despite being a routinary procedure for oral and maxillo-facial surgeons, may often result in a significantly negative impact in patient’s post-operatory quality of life. Among others, treatments based on oxygen-enriched oils have been shown to provide valuable [...] Read more.
Objective: Lower third impacted molar extraction, despite being a routinary procedure for oral and maxillo-facial surgeons, may often result in a significantly negative impact in patient’s post-operatory quality of life. Among others, treatments based on oxygen-enriched oils have been shown to provide valuable therapeutic benefits in promoting wound healing, and therefore improving the immediate post-operatory symptomatology. The aim of this triple-blinded randomized controlled study is to supplement the existing evidence in the scientific literature by assessing the effectiveness of NovoX®-Drop (Moss S.p.A., Lesa, Novara), a specific type of oxygen enriched oil-based device in reducing pain and inflammatory stimulus of post-surgical wounds following the extraction of lower third impacted molars. Materials and methods: Seventy-one patients undergoing surgical extraction of a single lower third impacted molar were randomly assigned to receive either NovoX®-Drop (Group A) or a glycerin-based gel (Group B). Additionally, both patient groups followed the same standard therapy with amoxicillin-clavulanic acid and ibuprofen. Data were collected preoperative (T0) and after three (T3) and seven (T7) days postoperative in order to assess the following outcomes: mean visual analogue scale (VAS) score during the seven days protocol treatment, total duration of nonsteroidal anti-inflammatory drug (NSAID) usage, trismus (maximum mouth opening) and facial oedema. Results: Group A (treatment group) reported significatively lower pain levels at T7 compared to group B (average VAS value during the week: Group A: 3.57 ± 0.39 cm; Group B: 4.47 ± 0.40 cm; p-value = 0.0014) despite a significatively shorter period of NSAID usage (average NSAID usage duration: Group A: 2.43 ± 0.38 days; Group B: 3.38 ± 0.44 days; p-value = 0.00001). Therefore, trismus seems to be better controlled in group A, although the difference between the groups did not reach the threshold for statistical significance. Conclusions: The results of this study suggest that application of NovoX®-Drop is capable of significantly reducing the post-operatory pain as well as NSAID usage, representing a promising and effective option for third impacted molar extraction surgery management. Full article
(This article belongs to the Special Issue New Perspective of Oral and Maxillo-Facial Surgery)
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16 pages, 1963 KiB  
Article
Temporomandibular Joint Ankylosis: Long-Term Outcomes with One-Stage Resection and Reconstruction Using Total Joint Alloplastic Replacement—A 20-Year Experience
by Giovanni Gerbino, Michela Omedè, Elisa Raveggi, Sara Silvestri, Emanuele Zavattero and Guglielmo Ramieri
J. Clin. Med. 2025, 14(13), 4639; https://doi.org/10.3390/jcm14134639 - 30 Jun 2025
Viewed by 328
Abstract
Background/Objectives: Temporomandibular joint (TMJ) ankylosis, characterized by osseous–fibrous fusion, severely impairs mandibular function. While alloplastic total joint replacement (TJR) is the gold standard, long-term outcomes remain understudied. The aim of this study is to evaluate the long-term esthetic and functional outcomes of prosthetic [...] Read more.
Background/Objectives: Temporomandibular joint (TMJ) ankylosis, characterized by osseous–fibrous fusion, severely impairs mandibular function. While alloplastic total joint replacement (TJR) is the gold standard, long-term outcomes remain understudied. The aim of this study is to evaluate the long-term esthetic and functional outcomes of prosthetic replacement and to retrospectively analyze our 20-year experience. Methods: A retrospective observational study (2003–2024) was conducted at a tertiary referral center in Turin and enrolled patients who underwent alloplastic total joint replacement for TMJ ankylosis. Data collected included demographic variables, etiology, characteristics of the ankylosis, prosthesis type (stock/custom), surgical details, and outcomes (maximal interincisal opening [MIO], pain, quality of life, diet consistency, Helkimo index, complications). Results: Among 28 patients (61% female, mean age 51.8 years), etiologies included post-traumatic (39%), osteoarthritis (32%), congenital (25%) and neoplastic (4%) causes. Custom prostheses were used in 57% of cases. Median follow-up was 11.5 years. Significant improvements were observed in MIO (p = 0.001), pain level (p = 0.001), quality of life (p = 0.001), diet score (p = 0.002), and Helkimo index (p = 0.001). Complications included facial nerve dysfunction (32.1%), salivary leakage (14.3%), and one recurrence (2.2%). Conclusions: Alloplstic TJR provides durable functional and esthetic restoration for TMJ ankylosis, with custom prostheses excelling in complex anatomies. Long-term stability (>10 years) supports its role as a definitive solution. Full article
(This article belongs to the Special Issue New Perspective of Oral and Maxillo-Facial Surgery)
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14 pages, 3462 KiB  
Article
Temporo-Mandibular Joint Functional Arthroplasty: Does It Improve the Short-Term Quality of Life in Patients with Painful Anterior Disc Displacement Without Reduction? A Retrospective Cohort Study
by Fabrizio Spallaccia, Silvia De Tomaso, Giulio Cirignaco, David Faustino Angelo, Luigi Angelo Vaira and Valentino Vellone
J. Clin. Med. 2025, 14(8), 2560; https://doi.org/10.3390/jcm14082560 - 8 Apr 2025
Viewed by 420
Abstract
Background: Anterior disc displacement without reduction (ADDwoR) of the temporomandibular joint (TMJ) often leads to persistent pain and reduced quality of life (QoL). Conservative treatments frequently fail to provide adequate symptom relief. Objective: To assess the short-term (≥6 months) effectiveness of [...] Read more.
Background: Anterior disc displacement without reduction (ADDwoR) of the temporomandibular joint (TMJ) often leads to persistent pain and reduced quality of life (QoL). Conservative treatments frequently fail to provide adequate symptom relief. Objective: To assess the short-term (≥6 months) effectiveness of functional arthroplasty in reducing pain and improving QoL in patients with ADDwoR unresponsive to conservative therapies. Methods: A retrospective cohort study was conducted on 105 patients (median age 38 years, 80% female) treated at Santa Maria Hospital from January 2018 to December 2021. All patients had unilateral painful ADDwoR confirmed via MRI and underwent functional arthroplasty. Primary outcomes included pain reduction (VAS) and QoL improvements (QoL-TMJ questionnaire). Covariates such as age, gender, and baseline mood disturbances were analyzed for associations with surgical outcomes. Statistical analyses included the Wilcoxon rank test, Friedman’s ANOVA, and Spearman’s rank correlation. Results: Postoperative VAS scores significantly decreased (8.0 pre-op vs. 2.0 post-op, p < 0.001). QoL-TMJ scores improved significantly in pain (p < 0.001), activity (p < 0.05), mood (p < 0.001), and anxiety (p < 0.01), but no significant changes were observed in chewing and speaking functions. Improvements in QoL correlated strongly with pain reduction. Gender and age did not influence the outcomes, though females reported higher baseline mood disturbances. Conclusions: Functional arthroplasty effectively reduces pain and improves QoL in patients with ADDwoR, regardless of age or gender. However, limited improvement in chewing and speaking abilities highlights the need for targeted interventions. Future studies should assess the long-term outcomes to confirm the sustained benefits of this procedure. Full article
(This article belongs to the Special Issue New Perspective of Oral and Maxillo-Facial Surgery)
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