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New Perspective of Oral and Maxillo-Facial Surgery

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 677

Special Issue Editors


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Guest Editor
Department of Life Science, Health, and Health Professions, LINK Campus University, Via del Casale di San Pio V, 44, 00165 Rome, Italy
Interests: oral and maxillofacial surgery; orthognathic surgery; oral surgery; TMJ disorders; TMJ surgery; craniofacial mal-formations; 3D printing custom-made

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Guest Editor
Maxillofacial Surgery Unit, Santa Maria Hospital, 93455 Terni, Italy
Interests: oral and maxillofacial surgery; orthognathic surgery; minimally invasive surgery; artificial Intelligence; CAD-CAM; endoscopic surgery; head-neck oncology; 3D printing custom-made

E-Mail Website
Guest Editor
1. Department of Orthodontics, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, 20123 Milan, Italy
2. Department of Life Sciences, Health and Healthcare Professions, Link Campus University, 00165 Rome, Italy
Interests: diagnosis and treatment plan in orthodontics of II and III class malocclusions; maxillo-facial surgery; sleep apnea syndrome; oral microbiome; diagnostic and therapeutic technologies in the orofacial field from childhood to adulthood; orthodontic fixed appliances; invisalign appliances; interceptive appliances

Special Issue Information

Dear Colleagues,

Oral and maxillofacial surgery is undergoing a paradigm shift, driven by rapid advancements in artificial intelligence (AI), deep and machine learning, and next-generation surgical technologies. The integration of these innovations with minimally invasive procedures, CAD-CAM systems, 3D printing, and patient-specific custom-made surgical solutions is reshaping the field, enabling unprecedented precision, efficiency, and personalization in surgical planning and execution.

This Special Issue aims to showcase groundbreaking research and cutting-edge developments that are revolutionizing oral and maxillofacial surgery. Topics of interest include, but are not limited to:

  • AI-Driven Innovations:
    • Machine learning algorithms for automated diagnosis, risk assessment, and treatment planning
    • AI-powered predictive modeling for surgical outcomes and complications
    • Deep learning applications in medical imaging, including segmentation, classification, and anomaly detection
    • AI-assisted robotic surgery and real-time intraoperative decision support
  • Advanced Surgical Technologies and Digital Workflows:
    • CAD-CAM and in-house custom-made surgical solutions for patient-specific implants, prosthetics, and anatomical models
    • 3D printing applications for personalized bone grafts, soft tissue scaffolds, and surgical guides
    • Virtual surgical planning (VSP) and augmented reality (AR) in preoperative simulations and intraoperative navigation
    • Integration of computational biomechanics and digital twin technology for precision surgery
  • Minimally Invasive and Regenerative Approaches:
    • Robotics and endoscopic techniques for less invasive interventions
    • AI-optimized strategies for accelerating tissue healing and regeneration
    • Bioengineered scaffolds and tissue-engineered constructs enhanced by machine learning algorithms
    • Advanced biomaterials for improved osseointegration and functional restoration

This Special Issue encourages multidisciplinary collaborations between surgeons, bioengineers, data scientists, and computational researchers to bridge the gap between cutting-edge technology and clinical application. We welcome original research, systematic reviews, and clinical trials that focus on the translational impact of these innovations, aiming to redefine standards in patient care.

By bringing together global expertise, this Special Issue will serve as a platform for transformative advancements, fostering the next generation of precision-driven, AI-enhanced, and patient-centered surgical solutions.

Dr. Valentino Vellone
Dr. Umberto Committeri
Prof. Dr. Alessandra Lucchese
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • maxillofacial surgery
  • esthetic surgery
  • orthognatic surgery
  • TMJ disorders
  • TMJ surgery
  • dental implant surgery
  • 3D imaging
  • printing applications
  • tissue engineering
  • personalized treatment planning
  • artificial intelligence
  • squamous cell carcinoma
  • skin tumors
  • plastic and reconstructive surgery
  • head and neck surgery
  • ENT surgery

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Published Papers (1 paper)

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Research

14 pages, 3462 KiB  
Article
Temporo-Mandibular Joint Functional Arthroplasty: Does It Improve the Short-Term Quality of Life in Patients with Painful Anterior Disc Displacement Without Reduction? A Retrospective Cohort Study
by Fabrizio Spallaccia, Silvia De Tomaso, Giulio Cirignaco, David Faustino Angelo, Luigi Angelo Vaira and Valentino Vellone
J. Clin. Med. 2025, 14(8), 2560; https://doi.org/10.3390/jcm14082560 - 8 Apr 2025
Viewed by 388
Abstract
Background: Anterior disc displacement without reduction (ADDwoR) of the temporomandibular joint (TMJ) often leads to persistent pain and reduced quality of life (QoL). Conservative treatments frequently fail to provide adequate symptom relief. Objective: To assess the short-term (≥6 months) effectiveness of [...] Read more.
Background: Anterior disc displacement without reduction (ADDwoR) of the temporomandibular joint (TMJ) often leads to persistent pain and reduced quality of life (QoL). Conservative treatments frequently fail to provide adequate symptom relief. Objective: To assess the short-term (≥6 months) effectiveness of functional arthroplasty in reducing pain and improving QoL in patients with ADDwoR unresponsive to conservative therapies. Methods: A retrospective cohort study was conducted on 105 patients (median age 38 years, 80% female) treated at Santa Maria Hospital from January 2018 to December 2021. All patients had unilateral painful ADDwoR confirmed via MRI and underwent functional arthroplasty. Primary outcomes included pain reduction (VAS) and QoL improvements (QoL-TMJ questionnaire). Covariates such as age, gender, and baseline mood disturbances were analyzed for associations with surgical outcomes. Statistical analyses included the Wilcoxon rank test, Friedman’s ANOVA, and Spearman’s rank correlation. Results: Postoperative VAS scores significantly decreased (8.0 pre-op vs. 2.0 post-op, p < 0.001). QoL-TMJ scores improved significantly in pain (p < 0.001), activity (p < 0.05), mood (p < 0.001), and anxiety (p < 0.01), but no significant changes were observed in chewing and speaking functions. Improvements in QoL correlated strongly with pain reduction. Gender and age did not influence the outcomes, though females reported higher baseline mood disturbances. Conclusions: Functional arthroplasty effectively reduces pain and improves QoL in patients with ADDwoR, regardless of age or gender. However, limited improvement in chewing and speaking abilities highlights the need for targeted interventions. Future studies should assess the long-term outcomes to confirm the sustained benefits of this procedure. Full article
(This article belongs to the Special Issue New Perspective of Oral and Maxillo-Facial Surgery)
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