Suicidal Ideation in Individuals with Cerebral Palsy: A Narrative Review of Risk Factors, Clinical Implications, and Research Gaps
Abstract
1. Introduction
2. Materials and Methods
2.1. Data Source and Search Strategy
2.2. Selection Procedures
3. Overview of the Literature
3.1. Prevalence of Mental Health Disorders in Cerebral Palsy
3.2. Suicidal Ideation and Risk Factors in CP
3.3. Structural and Systemic Barriers to Detection and Care
3.4. Protective Factors and Opportunities for Intervention
3.5. Implications and Practical Recommendations
3.6. Research Gaps and Future Directions
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
CP | Cerebral Palsy |
WHO | World Health Organization |
SI | Suicidal Ideation |
OSF | Open Science Framework |
MeSH | Medical Subject Headings |
CBT | Cognitive Behavioural Therapy |
AAC | Augmentative and Alternative Communication |
QoL | Quality of Life |
References
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ID | Author | Year | Country | Sample | Sample Age Mean ± SD (Range) | Sex (M:F) | Ethnicity | Outcome Measures | Main Findings | CP-Related Associations |
---|---|---|---|---|---|---|---|---|---|---|
#1 | Bhatnagar et al. [18] | 2024 | United States (Midwest), North America | 216,794 | 4.3 ± 5.1 years (0–21 years) | 55% M | 76,2% White, 94,7% non-Hispanic | CCSR | Higher anxiety, ADHD, and conduct/impulsivity; lower rates of depression and suicidal ideation (potential underdiagnosis) | Males showed higher ADHD and conduct problems; GMFCS levels III–V linked to more psychiatric diagnoses; Black and other ethnicities had higher rates of OCD, mood, and trauma/stress disorders. |
#2 | Bjorgaas et al. [6] | 2013 | Norway, Europe | 47 | 8.5 years (4–12 years) | NR | NR | Kiddie-SADS SDQ | 67% above 90th percentile (SDQ); 57% diagnosed with ≥1 psychiatric disorder (Kiddie-SADS); SDQ sensitive but not specific | Multiple co-occurring symptoms; peer relationship problems very common |
#3 | Clark et al. [21] | 2000 | United Kingdom (London), Europe | 47 | NR (4–12 years) | NR | NR | NR | High rates of bulbar problems (80%), drooling (86%), otitis media (60%), reflux/nutrition/aspiration issues (40%); mild tetraplegia in 91%, learning difficulties in 81%, neuropsychiatric problems in 41%, epilepsy in 28%; mean age at diagnosis 6 years; 32% had perisylvian polymicrogyria on neuroimaging. | Multisystem condition; overlapping phenotype with bilateral perisylvian syndrome; classified as a form of CP |
#4 | Honan et al. [19] | 2023 | Australia (Sydney), Oceania | 42 | 31.5 ± 13.5 years (NR) | NR | NR | DASS-21, DERS | High emotional difficulties: 33% showed moderate–severe depression and 60% moderate–severe anxiety; poor emotion regulation (DERS) closely linked to higher depression, anxiety, and stress. | Problematic emotion regulation associated with increased depression, anxiety, and stress |
#5 | Lal et al. [20] | 2022 | Canada, North America | NA | NR (13–24 years) | NR | NR | NA | Most common mental health issues: depression/mood (73% of studies), anxiety (39%), and social/behavioural difficulties (33%) | Parent reports indicate higher mental health problems in CP compared to controls |
#6 | Parkes et al. [22] | 2008 | Europe | 818 | NR (8–12 years) | NR | NR | SDQ | Higher odds of emotional and behavioural difficulties in children with CP versus typically developing peers | Physical and environmental contributors to psychological distress in CP |
#7 | Power et al. [23] | 2019 | Bangladesh, Asia | 327 | 15.1 ± 1.6 years (CP); 14.9 ± 1.6 years (controls) (NR) | 31.2% F (CP); 31.8% (controls) | NR | CPQoL-Teens, KIDSCREEN-27, SDQ | Adolescents with CP had poorer HRQoL and higher SDQ total difficulties than controls; odds of a “probable” SDQ total score were 7.8 times higher (self) and 12.0 times higher (proxy). | CP in rural areas associated with lower quality of life, compromised mental health, and impact of scarce resources |
#8 | Slaman et al. [24] | 2015 | Netherlands, Europe | 57 | NR (16–24 years) | NR | NR | FSS, CIS-f, HRQoL, GMFM, SSEBS, IMI, GSE | Reduced fatigue and pain; improved mental health and social support; effects partly mediated by increased physical activity and fitness. | Improvements partly mediated by changes in physical activity and fitness; social support changes minimally explained by these, suggesting independent psychosocial factors |
#9 | Smith et al. [25] | 2019 | United Kingdom (London), Europe | 6820 | 33.3 ± 15.5 years (NR) | 46.8% F | NR | NR | Increased risk of depression and anxiety | Higher risk in CP without ID; no significant increase in CP with ID |
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Alito, A.; De Domenico, C.; Settimo, C.; Vinci, S.L.; Quartarone, A.; Cucinotta, F. Suicidal Ideation in Individuals with Cerebral Palsy: A Narrative Review of Risk Factors, Clinical Implications, and Research Gaps. J. Clin. Med. 2025, 14, 5587. https://doi.org/10.3390/jcm14155587
Alito A, De Domenico C, Settimo C, Vinci SL, Quartarone A, Cucinotta F. Suicidal Ideation in Individuals with Cerebral Palsy: A Narrative Review of Risk Factors, Clinical Implications, and Research Gaps. Journal of Clinical Medicine. 2025; 14(15):5587. https://doi.org/10.3390/jcm14155587
Chicago/Turabian StyleAlito, Angelo, Carmela De Domenico, Carmela Settimo, Sergio Lucio Vinci, Angelo Quartarone, and Francesca Cucinotta. 2025. "Suicidal Ideation in Individuals with Cerebral Palsy: A Narrative Review of Risk Factors, Clinical Implications, and Research Gaps" Journal of Clinical Medicine 14, no. 15: 5587. https://doi.org/10.3390/jcm14155587
APA StyleAlito, A., De Domenico, C., Settimo, C., Vinci, S. L., Quartarone, A., & Cucinotta, F. (2025). Suicidal Ideation in Individuals with Cerebral Palsy: A Narrative Review of Risk Factors, Clinical Implications, and Research Gaps. Journal of Clinical Medicine, 14(15), 5587. https://doi.org/10.3390/jcm14155587