Obstructive Sleep Apnea (OSA)—New Pathways for Targeted Therapy
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Respiratory Medicine".
Deadline for manuscript submissions: closed (15 August 2022) | Viewed by 14907
Special Issue Editor
Interests: pulmonary medicine; sleep disorders; respiratory diseases; interstitial lung disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Obstructive sleep apnea syndrome (OSAS) is a chronic and prevalent disorder characterized by repetitive episodes of apneas and hypopneas during sleep. OSAS has been associated with inceased morbidity and mortality and has emerged as an important potential etiologic factor of several cardiometabolic diseases, including hypertension, atrial fibrillation, stroke, insulin resistance (IR), and diabetes mellitus.
The primary cause of OSAS is considered to be a narrow or collapsible upper airway (UA). However, in some patients, the impairment of the UA may be modest and other factors such as a low respiratory arousal threshold, respiratory control instability (high loop gain), and differences in pharyngeal dilator muscle control during sleep may play a crucial role, constituting potential therapeutic targets of OSAS.
Most of the treatment options for OSAS, including continuous positive airway pressure (CPAP), mandibular advancement devices, UA surgery, and hypoglossal nerve stimulation, are focused on improving the impaired UA anatomy. The ‘gold standard‘ of OSAS treatment remains CPAP; however, it has a rather low compliance rate. There also remain gaps in our scientific and clinical knowledge of different pathways for targeted therapy for OSAS. There is a need to identify key clinical phenotypes of OSAS in order to employ a more targeted treatment approach and also to identify predictive factors in order to facilitate personalized treatment of this disease.
Dr. Athanasia Pataka
Guest Editor
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Keywords
- Obstructive sleep apnea syndrome
- Phenotypes
- Targeted treatment
- CPAP
- Mandibular advancement devices
- UA surgery
- Hypoglossal nerve stimulation
- Medications
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