Advanced MR Imaging of Hepatocellular Carcinoma and Cirrhosis: A Multidisciplinary Overview

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nuclear Medicine & Radiology".

Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 2806

Special Issue Editors


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Guest Editor
IRCCS Fondazione SDN, Naples, Italy
Interests: radiology

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Guest Editor
IRCCS Synlab SDN, Naples, Italy
Interests: PET/MR; EEG/fMRI; neurology; psychiatry; connectome; disorders of consciousness; dementia

Special Issue Information

Dear Colleagues,

Hepatocellular carcinoma (HCC) is one of the most common cancers with a high mortality rate. Imaging plays a central role in HCC differential diagnosis and staging, and treatment response assessment, including ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI). While many efforts have been spent to standardize imaging assessment by LI-RADS, recent growing interest has been focused on assessing tissue properties using quantitative imaging, employing advanced diffusion models in MRI or emerging methods for quantification of tumor heterogeneity, such as radiomics. Finally, the recent development of novel molecular targeting tools (e.g., aptamers) against HCC may provide new options for a better treatment efficacy and tailored medicine approaches. The associations of these new quantitative parameters with clinical, pathologic, and genomic features remains again largely underestimated.

Special consideration will be given to papers covering hot topics including differential diagnosis between HCC and other focal liver lesions, quantitative approaches for tumor heterogeneity assessment, correlation studies among different omics, molecular imaging, and new biomarker/tool investigations. New insights from preclinical imaging in animal models of HCC are also welcome.

Dr. Lorenzo Mannelli
Dr. Carlo Cavaliere
Guest Editors

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Keywords

  • hepatocellular carcinoma
  • radiomics
  • MR imaging
  • predictive modeling
  • bioinformatics
  • biomarkers
  • aptamer
  • genomic
  • data correlation

Published Papers (1 paper)

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Review

23 pages, 1131 KiB  
Review
The Role of Non-Gaussian Models of Diffusion Weighted MRI in Hepatocellular Carcinoma: A Systematic Review
by Liberatore Tramontano, Carlo Cavaliere, Marco Salvatore and Valentina Brancato
J. Clin. Med. 2021, 10(12), 2641; https://doi.org/10.3390/jcm10122641 - 15 Jun 2021
Cited by 10 | Viewed by 2334
Abstract
The importance of Diffusion Weighted Imaging (DWI) in hepatocellular carcinoma (HCC) has been widely handled in the literature. Due to the mono-exponential model limitations, several studies recently investigated the role of non-Gaussian DWI models in HCC. However, their results are variable and inconsistent. [...] Read more.
The importance of Diffusion Weighted Imaging (DWI) in hepatocellular carcinoma (HCC) has been widely handled in the literature. Due to the mono-exponential model limitations, several studies recently investigated the role of non-Gaussian DWI models in HCC. However, their results are variable and inconsistent. Therefore, the aim of this systematic review is to summarize current knowledge on non-Gaussian DWI techniques in HCC. A systematic search of the literature, including PubMed, Google Scholar, MEDLINE, and ScienceDirect databases, was performed to identify original articles since 2010 that evaluated the role of non-Gaussian DWI models for HCC diagnosis, grading, response to treatment, and prognosis. Studies were grouped and summarized according to the non-Gaussian DWI models investigated. We focused on the most used non-Gaussian DWI models (Intravoxel Incoherent Motion (IVIM), Diffusion Kurtosis Imaging (DKI), and Stretched Exponential—SE). The quality of included studies was evaluated by using QUADAS-2 and QUIPS tools. Forty-three articles were included, with IVIM and DKI being the most investigated models. Although the role of non-Gaussian DWI models in clinical settings has not fully been established, our findings showed that their parameters may potentially play a role in HCC. Further studies are required to identify a standardized DWI acquisition protocol for HCC diagnosis, grading, response to treatment, and prognosis. Full article
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