Advanced MR Imaging of Hepatocellular Carcinoma and Cirrhosis: A Multidisciplinary Overview

Dear Colleagues,

Hepatocellular carcinoma (HCC) is one of the most common cancers with a high mortality rate. Imaging plays a central role in HCC differential diagnosis and staging, and treatment response assessment, including ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI). While many efforts have been spent to standardize imaging assessment by LI-RADS, recent growing interest has been focused on assessing tissue properties using quantitative imaging, employing advanced diffusion models in MRI or emerging methods for quantification of tumor heterogeneity, such as radiomics. Finally, the recent development of novel molecular targeting tools (e.g., aptamers) against HCC may provide new options for a better treatment efficacy and tailored medicine approaches. The associations of these new quantitative parameters with clinical, pathologic, and genomic features remains again largely underestimated.

Special consideration will be given to papers covering hot topics including differential diagnosis between HCC and other focal liver lesions, quantitative approaches for tumor heterogeneity assessment, correlation studies among different omics, molecular imaging, and new biomarker/tool investigations. New insights from preclinical imaging in animal models of HCC are also welcome.

Dr. Lorenzo Mannelli
Dr. Carlo Cavaliere
Guest Editors

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