Special Issue "Advances in Neurosurgery: Intraoperative Neurophysiology"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".

Deadline for manuscript submissions: 25 October 2023 | Viewed by 686

Special Issue Editor

Hospital Universitario Ramón y Cajal, Departamento de Neurofisiología Clínica, Madrid, Spain
Interests: clinical neurophysiology; movement disorders; imaging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The concept of neurophysiology-assisted Neurosurgery is well-established, and intraoperative neuromonitoring has rapidly become of routine use in many neurosurgical centers. Over the last 20 years, there have been many advances in the field of intraoperative monitoring. Intraoperative Neurophysiological methodologies for monitoring the nervous system can provide surgeons with real-time data that have been shown to correspond with post-operative neurological status. Over the past few years, novel neurophysiological monitoring and mapping techniques have emerged, particularly with regards to the intraoperative mapping of subcortical connectivity, both in the awake and asleep setting, as well as the monitoring of brainstem reflexes, spinal cord mapping, and intraoperative neurophysiology of the cerebellum.

This Special Issue will focus on recent methodologies that may either prove beneficial or are commonly used in neuromonitoring. The purpose is to describe the integration of neuromonitoring with surgical procedures.

This Special Issue is compiled for neurosurgeons, neurophysiologists, neurologists, anaesthesiologists, interventional neuroradiologists, orthopaedic surgeons, and plastic surgeons.

Dr. Ignacio Regidor Bailly-Bailliere
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • neurosurgery
  • intraoperative neurophysiological monitoring
  • neurosurgical procedures
  • neuromonitoring
  • multimodality
  • intraoperative neurophysiology
  • vascular surgery
  • epilepsy surgery
  • brain tumor surgery
  • spine
  • stereotaxic techniques
  • quality of life

Published Papers (1 paper)

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Predictive Value of Motor Evoked Potentials in the Resection of Intradural Extramedullary Spinal Tumors in Children
J. Clin. Med. 2023, 12(1), 41; https://doi.org/10.3390/jcm12010041 - 21 Dec 2022
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This study aimed to evaluate the predictive value of motor evoked potentials (MEP) in the resection of pediatric intradural extramedullary (IDEM) tumors. Additionally, we aimed to assess the impact of MEP alerts on the extent of tumor resection. Medical records of pediatric patients [...] Read more.
This study aimed to evaluate the predictive value of motor evoked potentials (MEP) in the resection of pediatric intradural extramedullary (IDEM) tumors. Additionally, we aimed to assess the impact of MEP alerts on the extent of tumor resection. Medical records of pediatric patients who underwent resection of IDEM tumors with the assistance of MEP between March 2011 and October 2020 were reviewed. The occurrence of postoperative motor deficits was correlated with intraoperative MEP alerts. Sixteen patients were included. MEP alerts appeared in 2 patients (12.5%), being reflective of new postoperative motor deficits. Among the remaining 14 patients without any intraoperative MEP alerts, no motor decline was found. Accordingly, MEP significantly predicted postoperative motor deficits, reaching sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 100% (p < 0.001). In the absence of MEP alerts, 11 out of 14 patients (78.6%) underwent GTR, while no patient with intraoperative IONM alerts underwent GTR (p = 0.025). Although MEP alerts limit the extent of tumor resection, the high sensitivity and PPV of MEP underline its importance in avoiding iatrogenic motor deficits. Concurrently, high specificity and NPV ensure safer tumor excision. Therefore, MEP can reliably support surgical decisions in pediatric patients with IDEM tumors. Full article
(This article belongs to the Special Issue Advances in Neurosurgery: Intraoperative Neurophysiology)
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