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State of the Art: Clinical Use of Durable Left Ventricular...
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State of the Art: Clinical Use of Durable Left Ventricular Assist Devices

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: closed (24 March 2022) | Viewed by 16459

Special Issue Editors

Prof. Joyce W. Wald

E-Mail Website
Guest Editor
Penn Heart and Vascular Center, Perelman Center for Advanced MedicineEast Pavilion, 2nd Floor, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
Interests: advanced heart failure; alcoholic cardiomyopathy; circulatory assist devices; arrhythmogenic right ventricular dysplasia; arterial insufficiency
Dr. Juan Ortega-legaspi

E-Mail Website
Guest Editor
Penn Heart and Vascular Center, Perelman Center for Advanced MedicineEast Pavilion, 2nd Floor, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
Interests: acute decompensated heart failure; circulatory assist devices; alcoholic cardiomyopathy; arrhythmogenic right ventricular dysplasia; arterial insufficiency

Special Issue Information

Dear Colleagues,

The current issue will underline in detail the current data behind the use of all devices currently available for mechanical circulatory support (MCS) in the adult with special focus on clinical use, guidelines and evidence based data. It is a compendium of all the clinical scenarios that heart failure specialists, critical care physicians and cardiac surgeons can encounter in the patient with end stage heart failure. It will include the very important topic of patient selection. In addition, it will define those devices that are used as a bridge to recovery, durable destination devices or heart transplantation. Furthermore, as it is a field in constant evolution, it will also point out the areas where data is lacking and therefore further clinical research is needed.

Prof. Joyce W. Wald
Dr. Juan Ortega-legaspi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • End stage heart failure
  • Ventricular assist devices
  • Recovery
  • Adult congenital heart disease

Published Papers (5 papers)

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Review

26 pages, 1681 KiB  
Review
LVAD as a Bridge to Remission from Advanced Heart Failure: Current Data and Opportunities for Improvement
by Christos P. Kyriakopoulos, Chris J. Kapelios, Elizabeth L. Stauder, Iosif Taleb, Rana Hamouche, Konstantinos Sideris, Antigone G. Koliopoulou, Michael J. Bonios and Stavros G. Drakos
J. Clin. Med. 2022, 11(12), 3542; https://doi.org/10.3390/jcm11123542 - 20 Jun 2022
Cited by 6 | Viewed by 2220
Abstract
Left ventricular assist devices (LVADs) are an established treatment modality for advanced heart failure (HF). It has been shown that through volume and pressure unloading they can lead to significant functional and structural cardiac improvement, allowing LVAD support withdrawal in a subset of [...] Read more.
Left ventricular assist devices (LVADs) are an established treatment modality for advanced heart failure (HF). It has been shown that through volume and pressure unloading they can lead to significant functional and structural cardiac improvement, allowing LVAD support withdrawal in a subset of patients. In the first part of this review, we discuss the historical background, current evidence on the incidence and assessment of LVAD-mediated cardiac recovery, and out-comes including quality of life after LVAD support withdrawal. In the second part, we discuss current and future opportunities to promote LVAD-mediated reverse remodeling and improve our pathophysiological understanding of HF and recovery for the benefit of the greater HF population. Full article
(This article belongs to the Special Issue State of the Art: Clinical Use of Durable Left Ventricular Assist Devices)
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13 pages, 1758 KiB  
Review
Durable Mechanical Circulatory Support in Adult Congenital Heart Disease: Reviewing Clinical Considerations and Experience
by Joshua Saef, Robert Montgomery, Ari Cedars, Wai H. Wilson Tang, Joseph W. Rossano, Katsuhide Maeda, Yuli Y. Kim and Sumeet S. Vaikunth
J. Clin. Med. 2022, 11(11), 3200; https://doi.org/10.3390/jcm11113200 - 03 Jun 2022
Cited by 6 | Viewed by 1726
Abstract
Adults with congenital heart disease (ACHD) patients are one of the fastest growing populations in cardiology, and heart failure (HF) is the most common cause of morbidity and mortality amongst them. The need for advanced HF therapies in ACHD patients stands to grow [...] Read more.
Adults with congenital heart disease (ACHD) patients are one of the fastest growing populations in cardiology, and heart failure (HF) is the most common cause of morbidity and mortality amongst them. The need for advanced HF therapies in ACHD patients stands to grow substantially. The anatomic considerations for placing durable mechanical circulatory support (MCS) devices in ACHD patients often require specialized approaches. Despite this, increasing evidence suggests that durable MCS can be implanted safely with favorable outcomes in ACHD patients. Expansion of MCS use in ACHD patients is imperative to improve their clinical outcomes. Knowledge of ACHD-specific anatomic and physiologic considerations is crucial to HF programs’ success as they work to provide care to this growing population. Full article
(This article belongs to the Special Issue State of the Art: Clinical Use of Durable Left Ventricular Assist Devices)
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14 pages, 1582 KiB  
Review
Predicting, Recognizing, and Treating Right Heart Failure in Patients Undergoing Durable LVAD Therapy
by Teresa S. Wang, Marisa Cevasco, Edo Y. Birati and Jeremy A. Mazurek
J. Clin. Med. 2022, 11(11), 2984; https://doi.org/10.3390/jcm11112984 - 25 May 2022
Cited by 8 | Viewed by 3034
Abstract
Despite advancing technology, right heart failure after left ventricular assist device implantation remains a significant source of morbidity and mortality. With the UNOS allocation policy change, a larger proportion of patients proceeding to LVAD are destination therapy and consist of an overall sicker [...] Read more.
Despite advancing technology, right heart failure after left ventricular assist device implantation remains a significant source of morbidity and mortality. With the UNOS allocation policy change, a larger proportion of patients proceeding to LVAD are destination therapy and consist of an overall sicker population. Thus, a comprehensive understanding of right heart failure is critical for ensuring the ongoing success of durable LVADs. The purpose of this review is to describe the effect of LVAD implantation on right heart function, review the diagnostic and predictive criteria related to right heart failure, and discuss the current evidence for management and treatment of post-LVAD right heart failure. Full article
(This article belongs to the Special Issue State of the Art: Clinical Use of Durable Left Ventricular Assist Devices)
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14 pages, 7207 KiB  
Review
Left Ventricular Assist Devices: A Primer for the Non-Mechanical Circulatory Support Provider
by Gregory S. Troutman and Michael V. Genuardi
J. Clin. Med. 2022, 11(9), 2575; https://doi.org/10.3390/jcm11092575 - 04 May 2022
Cited by 1 | Viewed by 3280
Abstract
Survival after implant of a left ventricular assist device (LVAD) continues to improve for patients with end-stage heart failure. Meanwhile, more patients are implanted with a destination therapy, rather than bridge-to-transplant, indication, meaning the population of patients living long-term on LVADs will continue [...] Read more.
Survival after implant of a left ventricular assist device (LVAD) continues to improve for patients with end-stage heart failure. Meanwhile, more patients are implanted with a destination therapy, rather than bridge-to-transplant, indication, meaning the population of patients living long-term on LVADs will continue to grow. Non-LVAD healthcare providers will encounter such patients in their scope of practice, and familiarity and comfort with the physiology and operation of these devices and common problems is essential. This review article describes the history, development, and operation of the modern LVAD. Common LVAD-related complications such as bleeding, infection, stroke, and right heart failure are reviewed and an approach to the patient with an LVAD is suggested. Nominal operating parameters and device response to various physiologic conditions, including hypo- and hypervolemia, hypertension, and device failure, are reviewed. Full article
(This article belongs to the Special Issue State of the Art: Clinical Use of Durable Left Ventricular Assist Devices)
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14 pages, 507 KiB  
Review
The History of Durable Left Ventricular Assist Devices and Comparison of Outcomes: HeartWare, HeartMate II, HeartMate 3, and the Future of Mechanical Circulatory Support
by Cecilia Berardi, Claudio A. Bravo, Song Li, Maziar Khorsandi, Jeffrey E. Keenan, Jonathan Auld, Sunny Rockom, Jennifer A. Beckman and Claudius Mahr
J. Clin. Med. 2022, 11(7), 2022; https://doi.org/10.3390/jcm11072022 - 05 Apr 2022
Cited by 4 | Viewed by 5405
Abstract
The utilization of left ventricular assist devices (LVADs) in end-stage heart failure has doubled in the past ten years and is bound to continue to increase. Since the first of these devices was approved in 1994, the technology has changed tremendously, and so [...] Read more.
The utilization of left ventricular assist devices (LVADs) in end-stage heart failure has doubled in the past ten years and is bound to continue to increase. Since the first of these devices was approved in 1994, the technology has changed tremendously, and so has the medical and surgical management of these patients. In this review, we discuss the history of LVADs, evaluating survival and complications over time. We also aim to discuss practical aspects of the medical and surgical management of LVAD patients and future directions for outcome improvement in this population. Full article
(This article belongs to the Special Issue State of the Art: Clinical Use of Durable Left Ventricular Assist Devices)
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