Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
5.7
3.0
Journals
JCM
Special Issues
Current Clinical Treatments and Challenges for Cardiovascular Diseases
share announcement

Current Clinical Treatments and Challenges for Cardiovascular Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1327

Special Issue Editors

Dr. Georgios Bouras

E-Mail Website
Guest Editor
Yale School of Medicine, Yale University, New Heaven, CT 06510, USA
Interests: heart failure; acute myocardial infarction; revascularization; cardiovascular disease; percutaneous coronary intervention; cardiogenic shock; atrial fibrillation; chronic coronary artery disease
Dr. Christos Kourek

E-Mail Website
Guest Editor
Clinical Ergospirometry, Exercise & Rehabilitation Laboratory, 1st Critical Care Medicine Department, Evangelismos Hospital, National and Kapodistrian University of Athens, 157 72 Athens, Greece
Interests: heart failure; endothelial progenitor cells; endothelium; myocardial infarction; revascularization; cardiopulmonary resuscitation; myocarditis; cardiopulmonary exercise testing; exercise training; rehabilitation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide, despite significant advances in diagnosis and treatment over the past decades. With an aging population and the rising prevalence of risk factors such as obesity, hypertension, and diabetes, the global burden of CVD continues to grow.

This Special Issue aims to explore the latest clinical approaches and emerging challenges in the treatment of cardiovascular disease. The scope encompasses a broad range of topics, including pharmacological therapies, surgical interventions, innovative medical devices, and lifestyle-based treatment strategies.

We invite cutting-edge research and review articles addressing novel therapeutic approaches, personalized medicine, and advancements in cardiovascular disease management. Contributions on emerging challenges, such as drug resistance, comorbidities, and the integration of new technologies in treatment strategies, are highly encouraged.

We are seeking original research, comprehensive literature and systematic reviews that push the boundaries of current knowledge and offer innovative solutions to the complex challenges in cardiovascular care.

Dr. Georgios Bouras
Dr. Christos Kourek
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heart failure
  • coronary artery disease
  • atrial fibrillation
  • cardiomyopathies
  • hypertension

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

15 pages, 241 KiB  
Article
Gender-Specific Outcomes in TAVI with Self-Expandable Valves: Insights from a Large Real-World Registry
by Alessandro Sticchi, Dario Grassini, Francesco Gallo, Stefano Benenati, Won-Keun Kim, Arif A. Khokhar, Tobias Zeus, Stefan Toggweiler, Roberto Galea, Federico De Marco, Antonio Mangieri, Damiano Regazzoli, Bernhard Reimers, Luis Nombela-Franco, Marco Barbanti, Ander Regueiro, Tommaso Piva, Josep Rodés-Cabau, Italo Porto, Antonio Colombo and Francesco Gianniniadd Show full author list remove Hide full author list
J. Clin. Med. 2025, 14(9), 3144; https://doi.org/10.3390/jcm14093144 - 1 May 2025
Abstract
Background/Objectives: Aortic stenosis (AS) is the most prevalent valvular heart disease in developed countries and imposes an increasing burden on aging populations. Although transcatheter aortic valve implantation (TAVI) has transformed the treatment of severe AS, current guidelines do not differentiate management based [...] Read more.
Background/Objectives: Aortic stenosis (AS) is the most prevalent valvular heart disease in developed countries and imposes an increasing burden on aging populations. Although transcatheter aortic valve implantation (TAVI) has transformed the treatment of severe AS, current guidelines do not differentiate management based on gender. This study aimed to investigate gender-based differences in procedural complications and one-year clinical outcomes in patients treated with next-generation self-expandable TAVI devices. Methods: This retrospective, multicenter international registry included 3862 consecutive patients who received either the ACURATE neo or Evolut R/Pro valve. Patients were stratified by gender; propensity score matching (PSM) adjusted for baseline differences. The primary endpoint was a composite of all-cause mortality or stroke at one year. Secondary endpoints included major vascular complications, major or life-threatening bleeding and acute kidney injury (AKI). Results: Of 3353 patients included (64.5% female), women were older (82.3 ± 5.6 vs. 81.1 ± 6.2 years, p < 0.001) and had higher STS scores (5.2 ± 3.9 vs. 4.5 ± 3.4%, p < 0.001). In the unmatched population, major vascular complications occurred in 7.7% of females versus 4.1% of males (p < 0.001), life-threatening bleeding in 2.8% vs. 1.4% (p = 0.016) and AKI in 8.5% vs. 5.7% (p = 0.009). After PSM, the primary endpoint was more frequent in females (9.4% vs. 6.0%, p = 0.014), largely driven by stroke (2.8% vs. 1.2%, p = 0.024), while overall mortality was similar (11.3% vs. 9.5%, p = 0.264). Conclusions: Despite comparable long-term survival, female patients undergoing TAVI with self-expandable valves experience higher rates of procedural complications, notably stroke and major vascular events. These findings underscore the need for tailored procedural strategies to improve outcomes in female patients. Full article
(This article belongs to the Special Issue Current Clinical Treatments and Challenges for Cardiovascular Diseases)

Review

Jump to: Research

16 pages, 3370 KiB  
Review
Campylobacter jejuni-Related Myocarditis: A Case Report and Review of the Literature
by Virginia Zouganeli, Christos Kourek, Vasiliki Bistola, Maria Mademli, Ioannis Grigoropoulos, Konstantinos Thomas, Sotirios Tsiodras, Gerasimos Filippatos and Dimitrios Farmakis
J. Clin. Med. 2024, 13(24), 7551; https://doi.org/10.3390/jcm13247551 - 11 Dec 2024
Viewed by 1054
Abstract
Campylobacter jejuni, a common cause of gastroenteritis worldwide, has also been associated with rare extraintestinal infections, including myocarditis. We report a unique case of a 24-year-old male who presented with febrile diarrhea and acute chest pain. Diagnostic investigations revealed elevated cardiac troponin [...] Read more.
Campylobacter jejuni, a common cause of gastroenteritis worldwide, has also been associated with rare extraintestinal infections, including myocarditis. We report a unique case of a 24-year-old male who presented with febrile diarrhea and acute chest pain. Diagnostic investigations revealed elevated cardiac troponin levels, normal electrocardiography findings, and myocardial inflammation on cardiac magnetic resonance imaging, confirming the diagnosis of acute myocarditis. Stool cultures identified Campylobacter jejuni as the causative agent. The patient was managed with supportive care, including hydration and electrolyte replacement, and a three-day course of azithromycin (500 mg daily). He achieved a full recovery and was discharged after eight days, with subsequent follow-up demonstrating the complete resolution of myocardial dysfunction. This case emphasizes the need to consider Campylobacter jejuni-related myocarditis in the differential diagnosis of young patients presenting with chest pain and diarrhea, along with an overview of its diagnostic and therapeutic challenges. Full article
(This article belongs to the Special Issue Current Clinical Treatments and Challenges for Cardiovascular Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop