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Cardiac Electrophysiology: Clinical Advances and Practice Updates—2nd Edition
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Cardiac Electrophysiology: Clinical Advances and Practice Updates—2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 15 December 2025 | Viewed by 1425

Special Issue Editor

Dr. Ibrahim Marai

E-Mail Website
Guest Editor
1. The Lydia and Carol Kittner, Lea and Benjamin Davidai Division of Cardiovascular Medicine and Surgery, Baruch Padeh Medical Center, Poriya, Israel
2. The Azrieli Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel
Interests: atrial fibrillation ablation; lead extraction; postoperative atrial fibrillation; ventricular tachycardia ablation; syncope
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is my pleasure to invite you to contribute to the Special Issue entitled “Cardiac Electrophysiology: Clinical Advances and Practice Updates—2nd Edition”. In the first volume, we published 15 papers. For more details, please visit:
https://www.mdpi.com/journal/jcm/special_issues/8X8K3QLO69

Nowadays, the interventional treatment of cardiac arrhythmias represents a continuous challenge. This is mainly due to the widening of indications for implantable electronic devices (CIEDs) and for catheter ablation (CA), as well as the continuous improvement of these technologies. Despite updates in the international guidelines and worldwide consensus, evidence gaps persist at all points. The aim of this Special Issue is to provide a comprehensive overview of the advances in the diagnosis and treatment of cardiac arrhythmias, with a particular interest in the use of innovative techniques and technologies in interventional therapies. Therefore, researchers in the field of clinical arrhythmology and electrophysiology are encouraged to submit their findings as original articles or reviews to this Special Issue.

Dr. Ibrahim Marai
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiac arrhythmias
  • cardiac implantable electronic device
  • catheter ablation
  • sudden cardiac death
  • lead extraction
  • atrial fibrillation
  • ventricular tachycardia
  • defibrillator therapy

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Related Special Issue

Published Papers (2 papers)

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Research

14 pages, 1059 KB  
Article
Nationwide Trends in Hospitalizations for Sudden Cardiac Arrest Before and During the COVID Outbreak
by Sarah Daoudi, Ariel Furer, Kevin John, Fadi Chalhoub, Jennifer Chee, Margaret Infeld, Gabby Elbaz-Greener, Munther Homoud, James Udelson, Christopher Madias and Guy Rozen
J. Clin. Med. 2025, 14(21), 7517; https://doi.org/10.3390/jcm14217517 - 23 Oct 2025
Viewed by 191
Abstract
Background/Objectives: Sudden cardiac arrest (SCA) accounts for ~50% of cardiovascular mortality in the U.S. Cardiovascular complications are common in acute and post-acute COVID-19 infection. We aimed to examine nationwide trends in SCA-related hospitalizations in the United States before and during the COVID-19 [...] Read more.
Background/Objectives: Sudden cardiac arrest (SCA) accounts for ~50% of cardiovascular mortality in the U.S. Cardiovascular complications are common in acute and post-acute COVID-19 infection. We aimed to examine nationwide trends in SCA-related hospitalizations in the United States before and during the COVID-19 outbreak. Methods: Using data from the National Inpatient Sample, we conducted a retrospective analysis of hospitalizations for SCA in the U.S. between 2016 and 2020. Sociodemographic and clinical characteristics and in-hospital mortality were compared between the pre-COVID (2016–2019) and COVID (2020) eras. Multivariable analysis was performed to identify factors associated with mortality. Results: Among a weighted total of 153,100 SCA hospitalizations between 2016 and 2020, the median age was 65 years, 62.7% were male, and 66.6% were white. There was a trend towards fewer hospitalizations in 2020 compared to prior years (n = 28,585 vs. naverage = 32,129, p = 0.07). In-hospital mortality remained unchanged between the pre-COVID and COVID eras (47.7% vs. 47.3%, p = 0.66). Increased mortality was associated with female sex (OR: 1.21; 95% CI: 1.15–1.28; p < 0.001), non-white race (OR: 1.24; 95% CI: 1.15–1.28; p < 0.001), history of renal failure (OR: 1.08; 95% CI: 1.02–1.15; p = 0.007), and diabetes (OR: 1.32; 95% CI: 1.25–1.39; p < 0.001). In 2020, 1.5% of the study population was diagnosed with COVID-19 infection, which was found to be independently associated with increased in-hospital mortality (OR: 1.57; 95% CI: 1.27–1.95; p < 0.001). Conclusions: In 2020, there was a trend towards a decrease in hospitalizations for SCA, while COVID-19 infection was independently associated with higher in-hospital mortality among patients admitted with SCA. Full article
(This article belongs to the Special Issue Cardiac Electrophysiology: Clinical Advances and Practice Updates—2nd Edition)
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16 pages, 2204 KB  
Article
Reviewing Strategies and Our Approach to Mapping and Ablation of Left Ventricular Summit Arrhythmias
by Ziad Abuiznait, Mohamad Ghanayem, Nizar Andria, Ali Sakhnini, Edo Birati and Ibrahim Marai
J. Clin. Med. 2025, 14(17), 6120; https://doi.org/10.3390/jcm14176120 - 29 Aug 2025
Viewed by 725
Abstract
Background: Left ventricular (LV) summit is an important origin for ventricular arrhythmias (VAs). However, the complex electroanatomic structure of LV summit and the surrounding anatomic sites makes ablation of this arrhythmia challenging. Aim: In this paper, we review the main strategies to mapping [...] Read more.
Background: Left ventricular (LV) summit is an important origin for ventricular arrhythmias (VAs). However, the complex electroanatomic structure of LV summit and the surrounding anatomic sites makes ablation of this arrhythmia challenging. Aim: In this paper, we review the main strategies to mapping and ablation of LV summit VAs and summarize our experience in this challenging ablation. Methods: To summarize our experience, we included all consecutive patients with outflow VAs referred to our institute for ablation between 2019 and 2024 who were eventually diagnosed with LV summit origin based on electroanatomical mapping and ablation result using stepwise and sequential ablation approach. Results: A total of 38 patients were found to have VAs from LV summit origin. Overall five patients had history of at least one failed ablation. V1 transition was seen in 15 patients, V2 transition in 12 patients, and V3 transition in 11 patients. Four patients had R wave pattern break in lead V2. Ablation was performed from the earliest activation or from one of the adjacent sites using stepwise and sequential approach. Acute suppression of VAs occurred in 35 patients without complications, except one case of pseudoaneurysm of femoral artery. Conclusions: Stepwise and sequential ablation approach can suppress VAs originating from LV summit in most patients. Full article
(This article belongs to the Special Issue Cardiac Electrophysiology: Clinical Advances and Practice Updates—2nd Edition)
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