Special Issue "Depression and Self-Injury in Adolescents: Mechanisms of Disease and Clinical Improvement"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Psychiatry".

Deadline for manuscript submissions: 31 July 2021.

Special Issue Editor

Dr. Kathryn R. Cullen
Guest Editor
Division of Child & Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Medical School, University of Minnesota, Minneapolis, MN 55454 USA
Interests: depression; self-injury; adolescents; neurobiology; treatment; mechanisms

Special Issue Information

Dear Colleagues,

Depression and self-injurious behavior are serious clinical problems that commonly emerge during the adolescent period and represent significant risk factors for suicide attempts and death by suicide in youth. Currently available evidence-based treatments are not effective for all adolescents struggling with depression and/or self-injury, underscoring the need to expand our tool chest and our ability to tailor treatments to optimally suit particular individuals. The field is just now beginning to understand some of the mechanisms underlying depression and self-injury in adolescents, and these new neurobiological insights can serve to guide novel intervention strategies. The goal of this Special Issue is to update the field on the cutting-edge research on depression and self-injury in adolescents, with a particular focus on research that sheds light on neurobiological mechanisms of disease and of clinical improvement within a neurodevelopmental framework. While papers reporting on unique, multimodal datasets from cross-sectional samples will be considered, we are particularly interested in studies with prospective, longitudinal study designs. Scientific contributions to this collection could include results from clinical trials which examined neurobiological or other relevant mechanisms along with clinical outcomes. Alternatively, insights into mechanisms of disease evolution and/or clinical improvement could be gleaned from results of naturalistic longitudinal studies.

Dr. Kathryn R. Cullen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • depression
  • self-injury
  • adolescent
  • treatment
  • mechanisms
  • clinical improvement

Published Papers

This special issue is now open for submission.
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