Special Issue "Diffusion-Weighted Magnetic Resonance Imaging (DWI): Clinical Potential and Applications"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nuclear Medicine & Radiology".

Deadline for manuscript submissions: 28 February 2022.

Special Issue Editor

Dr. Anna Caroli
E-Mail Website
Guest Editor
Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy
Interests: Medical imaging; image processing; DWI; renal MRI; ADPKD

Special Issue Information

Dear Colleagues,

Diffusion-weighted magnetic resonance imaging (DWI) is a non-invasive method sensitive to local water motion in the tissue. DWI signal can be interpreted using a variety of models, which attempt to capture not only simple diffusion effects, but also perfusion and anisotropy. As a tool to probe the microstructure, including the presence and potentially the degree of fibrosis, DWI has the potential to become an effective imaging biomarker.

Since its introduction in the 1980s, DWI has been increasingly used, first in the brain, then in oncology and, in the recent years, also to investigate whole-body pathophysiology, including but not limited to the kidney, liver, pancreas, and prostate. Moreover, thanks to its non-invasiveness, DWI has been widely adopted in the pediatric population.

The present Special Issue aims to highlight DWI’s clinical potential and provide an overview of possible applications in different clinical contexts, raising awareness among clinicians of a promising non-invasive functional MRI tool that, after long being used for research, is now ready to enter the clinics.

Dr. Anna Caroli
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • MRI
  • DWI
  • diffusion
  • microstructure
  • apparent diffusion coefficient
  • intravoxel incoherent motion

Published Papers (1 paper)

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Research

Article
Diffusion-Weighted MRI in the Evaluation of Renal Parenchymal Involvement during Febrile Urinary Tract Infections in Children: Preliminary Data
J. Clin. Med. 2021, 10(11), 2239; https://doi.org/10.3390/jcm10112239 - 21 May 2021
Viewed by 398
Abstract
Background: Urinary tract infection (UTI) is the most common infection in pediatric-age patients. Acute pyelonephritis (PNA) represents a worrying situation in pediatric patients due to the risk of sepsis and long-term cicatricial consequences. The purpose of this retrospective study is to evaluate [...] Read more.
Background: Urinary tract infection (UTI) is the most common infection in pediatric-age patients. Acute pyelonephritis (PNA) represents a worrying situation in pediatric patients due to the risk of sepsis and long-term cicatricial consequences. The purpose of this retrospective study is to evaluate the diagnostic role of DW-MRI in relation to clinical data, to understand if there are any clinical parameters useful in identifying which patients should undergo it. Methods: According to inclusion and exclusion criteria, we enrolled 51 patients ≤15 years old admitted to our Institute between September 2012 and April 2020 with a febrile UTI who underwent DW-MRI evaluation. Clinical, laboratory and imaging data were collected. Statistical analysis was performed. Results: 34 of 51 patients with an fUTI (66.7%) showed signs of acute parenchymal involvement at DW-MRI evaluation. In 27 of these 34 (79.4%), DW-MRI showed multiple areas of pyelonephritis. A statistically significant relationship (p = 0.0004) between older age at admission and pyelonephritis was demonstrated. No statistically significant relationship was found between the other clinical, anamnestic and laboratory parameters and the outcome of DWI. Only two ultrasound examinations allowed the identification of pathological areas on the renal parenchyma. Conclusions: From these preliminary investigations, we can say that selecting the patients with fUTI on whom to perform a DW-MRI is difficult. Nevertheless, thanks to the low cost, the very rare need for sedation and the accuracy in identifying pyelonephritic areas, the use of DW-MRI in patients with febrile UTI seems recommendable. Full article
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