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Rheumatoid Arthritis: Challenges, Innovations and Outcomes

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: 15 December 2025 | Viewed by 692

Special Issue Editor


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Guest Editor
Department of Precision and Regenerative Medicine and Jonian Area, Università Degli Studi di Bari Facoltà di Medicina e Chirurgia, 70124 Bari, Italy
Interests: myositis; rheumatoid arthritis; connective tissue diseases; systemic vasculitis

Special Issue Information

Dear Colleagues,

Rheumatoid arthritis (RA) remains a prevalent autoimmune condition characterized by systemic inflammation and joint destruction, leading to significant morbidity and healthcare burden. The proposed Special Issue, titled "Rheumatoid Arthritis: Challenges, Innovations, and Outcomes", aims to encapsulate the current research landscape, identifying persistent challenges within diagnosis, treatment, and patient management. It seeks to highlight innovative approaches that promise to redefine clinical practices, from advancements in biotechnological treatments to novel therapeutic strategies and diagnostic tools.

This Special Issue will explore the multidisciplinary efforts underway to improve outcomes for RA patients, including the development of personalized medicine approaches, the integration of digital health technologies, and the evaluation of socio-economic factors affecting patient care. It invites contributions that address the core problems in RA management, such as early detection, prediction of treatment responses, and mitigation of long-term complications.

We aim to mobilize a global community of researchers, clinicians, and healthcare professionals to share their findings, insights, and experiences. By doing so, this Special Issue intends to foster a collaborative environment conducive to accelerating progress in combating RA; improving patient quality of life; and ultimately, achieving better health outcomes.

Dr. Marco Fornaro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • rheumatoid arthritis
  • pathogenesis
  • treatments
  • outcomes
  • autoimmunity

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Published Papers (1 paper)

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Research

13 pages, 1207 KiB  
Article
Subaxial Subluxation (SAS) and Cervical Deformity in Patients with Rheumatoid Arthritis in Relation to Selected Sagittal Balance Parameters
by Robert Wróblewski, Małgorzata Mańczak and Robert Gasik
J. Clin. Med. 2025, 14(14), 4954; https://doi.org/10.3390/jcm14144954 - 13 Jul 2025
Viewed by 281
Abstract
Introduction: Synovitis and damage to natural stabilizers of many axial and peripheral joints make patients with rheumatoid arthritis particularly susceptible to sagittal balance disorders of the axial skeleton. This may determine the high individual variability of cervical spine deformities as well as differences [...] Read more.
Introduction: Synovitis and damage to natural stabilizers of many axial and peripheral joints make patients with rheumatoid arthritis particularly susceptible to sagittal balance disorders of the axial skeleton. This may determine the high individual variability of cervical spine deformities as well as differences in the rate of development of disease symptoms in these patients, such as radiculopathy and myelopathy. Methods: In the scientific literature, in addition to systemic factors, more and more attention is paid to work on biomechanical factors in the development of cervical spine instability. One of the methods for assessing the influence of biomechanical factors, which can also be used in everyday practice, is the analysis of radiological parameters of sagittal balance. Results: Among the selected sagittal balance parameters studied, a statistical relationship between C4 and C5 distance and the OI parameter has been found, indicating a relationship to a parameter that remains constant throughout an individual’s life in the group of patients with disease duration over 20 years. Conclusions: The development of instability and deformity in the subaxial segment of the cervical spine in patients with rheumatoid arthritis may be the result of insufficiently understood components of biomechanical factors; hence, further research in this field is necessary. Full article
(This article belongs to the Special Issue Rheumatoid Arthritis: Challenges, Innovations and Outcomes)
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