Special Issue "Clinical Advances in Chronic Intestinal Diseases Treatment"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editors

Dr. Jose E. Mesonero
E-Mail Website
Guest Editor
Department of Pharmacology and Physiology, University of Zaragoza, Zaragoza, Spain
Interests: Gastroenterology; Gastrointestinal Disorders; Endocrinology; Intestinal transport; Serotonin
Dr. Eva Latorre
E-Mail Website
Guest Editor
Department of Biochemistry and Molecular and Cellular Biology, University of Zaragoza, Zaragoza, Spain
Interests: Serotonergic system, Immunity, RNA biology, Microbiota

Special Issue Information

Dear Colleagues,

Over the past two decades, several advances have been made in the management of patients with chronic intestinal diseases from both evaluative and therapeutic perspectives. Among other chronic intestinal pathologies, irritable bowel syndrome (IBS), involving gut-brain axis alterations that causes abdominal pain, bloating, and alternating diarrhea and constipation, and inflammatory bowel disease (IBD), characterized by chronic inflammation of the gastrointestinal tract, are the best known and with the highest incidence and prevalence. Both chronic conditions, with significant overlap in terms of symptoms, pathophysiology, and treatment, need to be managed over long term and sometimes with overlay treatments.

However, new clinical approaches with novel mechanisms of action could offer new options for treatment of chronic intestinal diseases not optimally caracterized and controlled. Integration of novel approaches into clinical practice together with emerging strategies for management of chronic intestinal diseases will allow physicians to improve patient outcomes and potentially alter the progressive course of these diseases. Chronic intestinal diseases have a significant effect on the quality of life of affected patients and the increasing number of cases worldwide is a growing concern. Because of the overall burden of these diseases and its multifactorial etiology, efforts have been made to improve the medical management of these conditions.

This special issue aims to gather in one collection reviews and original contributions to illustrate the state of the art to provide novel approaches for the treatment of chronic intestinal diseases and the envisaged future in the management of these pathologies. On behalf of the Journal of Clinical Medicine you are cordially invited to contribute an article to the Special Issue “Clinical Advances in Chronic Intestinal Diseases Treatment”. Research articles, Reviews and Communications are welcome.

Dr. Jose E. Mesonero
Dr. Eva Latorre
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Functional Intestinal Disorders
  • Inflammatory Bowel Disease
  • Irritable Bowel Syndrome
  • Crohn’s Disease
  • Ulcerative Colitis
  • Celiac Disease
  • Microbiota
  • Gut-brain axis
  • Biosimilars
  • Alternative pharmacological treatments

Published Papers (3 papers)

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Research

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Article
Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease: A Multicentre Study of Geteccu
J. Clin. Med. 2021, 10(19), 4402; https://doi.org/10.3390/jcm10194402 (registering DOI) - 26 Sep 2021
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Abstract
Background: The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab. Aims: To evaluate the impact of biologics on the risk [...] Read more.
Background: The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab. Aims: To evaluate the impact of biologics on the risk of PC. Methods: A retrospective study was performed in 37 centres. Patients treated with biologics within 12 weeks before surgery were considered “exposed”. The impact of the exposure on the risk of 30-day PC and the risk of infections was assessed by logistic regression and propensity score-matched analysis. Results: A total of 1535 surgeries were performed on 1370 patients. Of them, 711 surgeries were conducted in the exposed cohort (584 anti-TNF, 58 vedolizumab and 69 ustekinumab). In the multivariate analysis, male gender (OR: 1.5; 95% CI: 1.2–2.0), urgent surgery (OR: 1.6; 95% CI: 1.2–2.2), laparotomy approach (OR: 1.5; 95% CI: 1.1–1.9) and severe anaemia (OR: 1.8; 95% CI: 1.3–2.6) had higher risk of PC, while academic hospitals had significantly lower risk. Exposure to biologics (either anti-TNF, vedolizumab or ustekinumab) did not increase the risk of PC (OR: 1.2; 95% CI: 0.97–1.58), although it could be a risk factor for postoperative infections (OR 1.5; 95% CI: 1.03–2.27). Conclusion: Preoperative administration of biologics does not seem to be a risk factor for overall PC, although it may be so for postoperative infections. Full article
(This article belongs to the Special Issue Clinical Advances in Chronic Intestinal Diseases Treatment)
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Article
Clinical Outcomes of Pediatric Chronic Intestinal Pseudo-Obstruction
J. Clin. Med. 2021, 10(11), 2376; https://doi.org/10.3390/jcm10112376 - 28 May 2021
Cited by 2 | Viewed by 603
Abstract
Chronic intestinal pseudo-obstruction (CIPO) is an extremely rare condition with symptoms of recurrent intestinal obstruction without any lesions. The outcomes of pediatric CIPO and predictors for the outcomes have not yet been well established. We analyzed the clinical outcomes and associated factors for [...] Read more.
Chronic intestinal pseudo-obstruction (CIPO) is an extremely rare condition with symptoms of recurrent intestinal obstruction without any lesions. The outcomes of pediatric CIPO and predictors for the outcomes have not yet been well established. We analyzed the clinical outcomes and associated factors for the outcomes of pediatric CIPO. We retrospectively reviewed 66 primary CIPO patients diagnosed between January 1985 and December 2017. We evaluated parenteral nutrition (PN) factors such as PN duration, PN use over 6 months, home PN, and mortality as outcomes. We selected onset age, presence of urologic symptoms, pathologic type, and involvement extent as predictors. The early-onset CIPO was found in 63.6%, and 21.2% of the patients presenting with urologic symptoms. Of the 66 patients, 47 and 11 had neuropathy and myopathy, respectively. The generalized involvement type accounted for 83.3% of the cases. At the last follow-up, 24.2% of the patients required home PN management. The mean duration of PN was 11.8 ± 21.0 months. The overall mortality rate of primary CIPO was 18.2%. PN factors were predicted by the urologic symptoms and extent of involvement. However, mortality was predicted by pathologic type. The onset age was not significantly associated with the outcomes. CIPO with urologic symptoms and generalized CIPO had poor PN outcomes. Myopathy is suggested as a predictor of mortality in children with primary CIPO. Full article
(This article belongs to the Special Issue Clinical Advances in Chronic Intestinal Diseases Treatment)
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Review

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Review
Neurotransmitter Dysfunction in Irritable Bowel Syndrome: Emerging Approaches for Management
J. Clin. Med. 2021, 10(15), 3429; https://doi.org/10.3390/jcm10153429 - 31 Jul 2021
Cited by 1 | Viewed by 718
Abstract
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder whose aetiology is still unknown. Most hypotheses point out the gut-brain axis as a key factor for IBS. The axis is composed of different anatomic and functional structures intercommunicated through neurotransmitters. However, the implications [...] Read more.
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder whose aetiology is still unknown. Most hypotheses point out the gut-brain axis as a key factor for IBS. The axis is composed of different anatomic and functional structures intercommunicated through neurotransmitters. However, the implications of key neurotransmitters such as norepinephrine, serotonin, glutamate, GABA or acetylcholine in IBS are poorly studied. The aim of this review is to evaluate the current evidence about neurotransmitter dysfunction in IBS and explore the potential therapeutic approaches. IBS patients with altered colorectal motility show augmented norepinephrine and acetylcholine levels in plasma and an increased sensitivity of central serotonin receptors. A decrease of colonic mucosal serotonin transporter and a downregulation of α2 adrenoceptors are also correlated with visceral hypersensitivity and an increase of 5-hydroxyindole acetic acid levels, enhanced expression of high affinity choline transporter and lower levels of GABA. Given these neurotransmitter dysfunctions, novel pharmacological approaches such as 5-HT3 receptor antagonists and 5-HT4 receptor agonists are being explored for IBS management, for their antiemetic and prokinetic effects. GABA-analogous medications are being considered to reduce visceral pain. Moreover, agonists and antagonists of muscarinic receptors are under clinical trials. Targeting neurotransmitter dysfunction could provide promising new approaches for IBS management. Full article
(This article belongs to the Special Issue Clinical Advances in Chronic Intestinal Diseases Treatment)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

1. Neurotransmitter Dysfunction in Irritable Bowel Syndrome: Emerging Approaches for Management

2. Which is the first biologic we should choose in an IBD patient?

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