Special Issue "Advances in Preterm Delivery"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 31 May 2021.

Special Issue Editor

Prof. Dr. Eyal Sheiner
Guest Editor
Department of Obstetrics and Gynecology, Soroka University Medical Center, Israel
Interests: obstetrics; high risk pregnancy; clinical studies; placental abruption; placenta previa; pregnancy as a window of opportunity to detect long-term diseases; obesity in pregnancy; maternal-fetal medicine; perinatal outcome

Special Issue Information

Dear colleagues,

Preterm delivery (PTD; <37 weeks’ gestation) complicates 5%–13% of deliveries worldwide depending on the geographical and demographical characteristics of the population tested. Based on data from 184 countries, the global average preterm birth rate in 2010 was 11.1%, giving a worldwide total of 14.9 million. It is the leading cause of perinatal morbidity and mortality, as well as maternal morbidity. In fact, prematurity has both short- and long-term consequences for affected offspring and can leave these individuals with lifelong disabilities, even after the available interventions are attempted. Morbidity and mortality increase in proportion to decreasing gestational age, and numbers are especially grave in those defined as “very” preterm (<32 weeks) and “extremely” preterm (<28 weeks). 

Many factors can predispose to the development of preterm birth, but it is useful to categorize preterm birth into three general etiologic groups: spontaneous labor with intact membranes, preterm premature rupture of membranes (PPROM) leading to preterm birth, and labor induction due to maternal or fetal factors. While various risk factors for preterm birth are well recognized, the etiology for preterm birth is multifactorial. Preterm parturition is a syndrome resulting from premature activation of the common pathway of parturition, including: an increased myometrial contractility; cervical ripening/dilatation and effacement; and membrane/decidual activation. The activation of human parturition is the result of anatomical, physiological, biochemical, endocrinological, immunological, and clinical events that occur in the mother and/or fetus in both term and preterm labor. In most cases of spontaneous labor at term, there is synchronous activation of the common pathway. However, preterm parturition is the clinical presentation of different underlying mechanisms, including intrauterine infection, uteroplacental ischemia, uterine over-distention, cervical disease, allergic phenomena, and endocrine disorders.

Because the prevalence of preterm birth is so high, it is thought to put more financial, medical, and emotional stress on affected communities than any other perinatal issue. In past years, most of the research interest resulted in the prevention of preterm birth in order to alleviate the complications of prematurity. However, recent evidence suggests that the effect of preterm birth goes beyond the impact on the future health of both the mother and her offspring and the specific delivery in which preterm delivery has occurred.

We sincerely welcome your submission to the Journal of Clinical Medicine.

Prof. Dr. Eyal Sheiner
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Epidemiology of PTD
  • Risk factors
  • Symptoms
  • Classification
  • Pathophysiology
  • Genetics
  • Diagnosis
  • Ultrasound
  • Multiple gestations
  • Prevention
  • Intervention
  • Complications
  • Long-term consequences for the mother and child

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:


Open AccessArticle
Identification of Vaginal Microbial Communities Associated with Extreme Cervical Shortening in Pregnant Women
J. Clin. Med. 2020, 9(11), 3621; https://doi.org/10.3390/jcm9113621 - 10 Nov 2020
The vaginal microbiota plays a critical role in pregnancy. Bacteria from Lactobacillus spp. are thought to maintain immune homeostasis and modulate the inflammatory responses against pathogens implicated in cervical shortening, one of the risk factors for spontaneous preterm birth. We studied vaginal microbiota [...] Read more.
The vaginal microbiota plays a critical role in pregnancy. Bacteria from Lactobacillus spp. are thought to maintain immune homeostasis and modulate the inflammatory responses against pathogens implicated in cervical shortening, one of the risk factors for spontaneous preterm birth. We studied vaginal microbiota in 46 pregnant women of predominantly Caucasian ethnicity diagnosed with short cervix (<25 mm), and identified microbial communities associated with extreme cervical shortening (≤10 mm). Vaginal microbiota was defined by 16S rRNA gene sequencing and clustered into community state types (CSTs), based on dominance or depletion of Lactobacillus spp. No correlation between CSTs distribution and maternal age or gestational age was revealed. CST-IV, dominated by aerobic and anaerobic bacteria different than Lactobacilli, was associated with extreme cervical shortening (odds ratio (OR) = 15.0, 95% confidence interval (CI) = 1.56–14.21; p = 0.019). CST-III (L. iners-dominated) was also associated with extreme cervical shortening (OR = 6.4, 95% CI = 1.32–31.03; p = 0.02). Gestational diabetes mellitus (GDM) was diagnosed in 10/46 women. Bacterial richness was significantly higher in women experiencing this metabolic disorder, but no association with cervical shortening was revealed by statistical analysis. Our study confirms that Lactobacillus-depleted microbiota is significantly associated with an extremely short cervix in women of predominantly Caucasian ethnicity, and also suggests an association between L. iners-dominated microbiota (CST III) and cervical shortening. Full article
(This article belongs to the Special Issue Advances in Preterm Delivery)
Show Figures

Figure 1

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

1. Prevention of preterm delivery
Back to TopTop