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Mechanical Circulatory Support in Circulatory Failure: The State of the...
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Mechanical Circulatory Support in Circulatory Failure: The State of the Art

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Intensive Care".

Deadline for manuscript submissions: 20 May 2024 | Viewed by 877

Special Issue Editors

Dr. Raphaël Giraud

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Guest Editor
1. Intensive Care Unit, Geneva University Hospitals, CH-1205 Geneva, Switzerland
2. Geneva Hemodynamic Research Group, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland
3. Surgical Intensive Care Division, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland
Interests: anaesthetics; critical care medicine; hemodynamics; cardiac output; transesophageal echocardiography; echocardiography; mechanical ventilation; intensive care medicine
Special Issues, Collections and Topics in MDPI journals
Dr. Benjamin Assouline

E-Mail Website
Guest Editor
1. Division of Intensive Care, Department of Acute Medicine, Geneva University Hospitals, Geneva, Switzerland
2. Geneva Hemodynamic Research Group, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland
3. Faculty of Medicine, University of Geneva, Geneva, Switzerland
Interests: cardiogenic shock; acute respiratory distress syndrome; extracorporeal life support; mechanical circulatory support
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the last decade, temporary mechanical circulatory support (tMCS) has progressively become crucial to the management of critically ill patients presenting refractory circulatory failure.

Percutaneous devices are now widely employed as a bridge to recovery, long-term MCS, organ transplant or decision. The applications of temporary MCS are no longer restricted to patients presenting acute myocardial-infarction-associated cardiogenic shock (AMI-CS) or post-cardiotomy syndrome. Indeed, emerging applications have increased significantly in recent years, including, notably, septic cardiomyopathy, massive pulmonary embolism, obstetric catastrophes (embolic or cardiogenic), bridge to liver, lung and cardiac transplant and ECPR.

In addition to VA-ECMO, which is considered the gold-standard of extracorporeal life support in modern cardiac critical care, other devices (IMPELLA, the Protek-DUO and TandemHeart) are now available and increasingly employed.

While the evidence supporting MCS in numerous contexts remains scarce, several trials have recently been published on this topic. The aim of this Special Issue is to provide an update on the state of the art regarding the utilization and management of temporary MCS in refractory circulatory failure, beyond its usual applications in AMICS and post-cardiotomy-associated cardiogenic shock. We are seeking the submission of original research articles discussing the physiology and physiopathology of the application of tMCS, and articles that discuss fundamental and clinical research areas related to this topic.

You may choose our Joint Special Issue in Life.

Dr. Raphaël Giraud
Dr. Benjamin Assouline
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extracorporeal life support
  • venoarterial extra corporeal membrane oxygenation
  • cardiogenic shock
  • septic cardiomyopathy
  • transplant
  • acute liver failure
  • obstetric catastrophes
  • heart left ventricle venting

Published Papers (1 paper)

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Research

11 pages, 790 KiB  
Article
Patient-Related Factors Associated with Adverse Outcomes Following Weaning from Veno-Arterial Extracorporeal Membrane Oxygenation
by Marius Keller, Henning Gloeckner, Sibel Sari-Yavuz, Helene A. Haeberle, Christian Schlensak, Peter Rosenberger, Harry Magunia and Michael Koeppen
J. Clin. Med. 2023, 12(23), 7406; https://doi.org/10.3390/jcm12237406 - 29 Nov 2023
Viewed by 672
Abstract
Background: Veno-arterial extracorporeal membrane oxygenation (vaECMO) removal reflects a critical moment and factors of adverse outcomes are incompletely understood. Thus, we studied various patient-related factors during vaECMO removal to determine their association with outcomes. Methods: A total of 58 patients from a university [...] Read more.
Background: Veno-arterial extracorporeal membrane oxygenation (vaECMO) removal reflects a critical moment and factors of adverse outcomes are incompletely understood. Thus, we studied various patient-related factors during vaECMO removal to determine their association with outcomes. Methods: A total of 58 patients from a university hospital were included retrospectively. Demographic, clinical, and echocardiographic parameters were recorded while under vaECMO support, as well as the need for inotropic and vasoactive-inotropic scores (VIS). Successful weaning was defined as 28-day survival without reinitiation of vaECMO. Results: Patient age differed significantly between patients with a successful and a failed vaECMO weaning (54 ± 14 vs. 62 ± 12 years, p = 0.029). In univariable logistic regression, age (OR 0.952 (0.909–0.997), p = 0.038), the necessities for inotropic agents at the time of echocardiography (OR 0.333 (0.113–0.981), p = 0.046), and vaECMO removal (OR 0.266 (0.081–0.877), p = 0.030) as well as the dobutamine dose during removal (OR 0.649 (0.473–0.890), p = 0.007), were significantly associated with a successful weaning from vaECMO. Age (HR 1.048 (1.006–1.091), p = 0.024) and the VIS (HR 1.030 (1.004–1.056), p = 0.025) at the time of vaECMO removal were independently associated with survival in bivariable Cox regression. In Kaplan–Meier analysis, a VIS of >5.1 at vaECMO removal was associated with impaired survival (log-rank p = 0.025). Conclusions: In this cohort, age and the extent of vasoactive-inotropic agents were associated with adverse outcomes following vaECMO, whereas echocardiographic biventricular function during vaECMO support was not. Full article
(This article belongs to the Special Issue Mechanical Circulatory Support in Circulatory Failure: The State of the Art)
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