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New Insights into Diabetes and Cardiovascular Diseases
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New Insights into Diabetes and Cardiovascular Diseases

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: 10 October 2025 | Viewed by 483

Special Issue Editor

Dr. Simona Giubilato

E-Mail Website
Guest Editor
Cardiology Department, Cannizzaro Hospital, 95126 Catania, Italy
Interests: coronary artery disease; cardiovascular intensive care; anthitrombotic therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the last decade, there has been remarkable progress in our understanding of the molecular and pathophysiological mechanisms linking diabetes to cardiovascular diseases. Furthermore, recent years have seen the discovery of new pharmacological approaches that not only address hyperglycemia but also offer significant cardiovascular benefits.

In particular, the emergence of SGLT2 inhibitors (SGLT2is) and GLP-1 receptor agonists (GLP-1as) has revolutionized the management of diabetic patients with cardiovascular diseases. These therapies have demonstrated improved outcomes in both atherosclerotic cardiovascular diseases and heart failure, marking a significant shift in therapeutic strategies and patient care.

For this Special Issue, we welcome contributions from researchers and clinicians to explore the latest findings in this critical area. We encourage the submission of original research, reviews, and clinical studies that delve into the mechanisms by which diabetes exacerbates cardiovascular disease, the impact of emerging therapies, and the potential for these innovations to improve prognosis.

We look forward to your valuable contributions to this Special Issue, which aims to shape the future of diabetes and cardiovascular disease management.

Dr. Simona Giubilato
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetes
  • cardiovascular diseases
  • heart failure
  • pharmacological approaches
  • SGLT2 inhibitors
  • GLP-1 receptor agonists

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Published Papers (1 paper)

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Research

21 pages, 2291 KiB  
Article
Active Detection of Glucose Metabolism Disorders Prior to Coronary Artery Bypass Grafting: Associations with In-Hospital Postoperative Complications
by Alexey N. Sumin, Natalia A. Bezdenezhnykh, Ekaterina. V. Belik, Andrew V. Bezdenezhnykh, Olga V. Gruzdeva and Olga L. Barbarash
J. Clin. Med. 2025, 14(9), 3123; https://doi.org/10.3390/jcm14093123 - 30 Apr 2025
Viewed by 222
Abstract
Background/Objectives: Patients with coronary artery disease undergoing coronary artery bypass grafting (CABG) have a high prevalence of type 2 diabetes mellitus (T2DM) and prediabetes. Glucose metabolism disorders (GMDs) are often asymptomatic and remain undetected, but untreated they can have adverse effects. To evaluate [...] Read more.
Background/Objectives: Patients with coronary artery disease undergoing coronary artery bypass grafting (CABG) have a high prevalence of type 2 diabetes mellitus (T2DM) and prediabetes. Glucose metabolism disorders (GMDs) are often asymptomatic and remain undetected, but untreated they can have adverse effects. To evaluate the possibilities of active screening in identifying T2DM and prediabetes before CABG and to assess the impact of GMD on the incidence of postoperative complications. Methods: This study included 1021 patients who underwent CABG in 2016–2018 at the department of cardiovascular surgery, whose glycemic status was determined. All patients had their glycated hemoglobin (HbA1c) levels measured; those without a previous diagnosis of diabetes underwent an oral glucose tolerance test. The frequency of newly diagnosed diabetes and prediabetes was evaluated. Postoperative complication rates were analyzed among patient groups with various types of GMDs and normal blood glucose levels. Results: Screening before CABG increased the number of patients with established type 2 diabetes from 20.9 to 27.8% and the number of people with prediabetes from 2.7% to 31.7%. When analyzing hospital complications, patients with type 2 diabetes compared to patients with normoglycemia were significantly more likely to develop heart failure (p = 0.010), multiple organ failure (p = 0.002), require extracorporeal homeostasis correction (p = 0.011), and wound dehiscence (p = 0.004). Nine patients (0.9%) died following CABG without being discharged from the hospital, with 90% of these deaths occurring in patients with GMDs. Any GMD (diabetes or prediabetes) was associated with an increased incidence of postoperative heart failure (OR 1.259; p = 0.011), rhythm disturbances (OR 1.236; p = 0.010), major cardiovascular complications and/or heart failure (OR 1.193; p = 0.039), and all cardiovascular complications (OR 1.455; p = 0.002). In the presence of any GMD, the risk of multiple organ failure increased by 2.5 times (OR 2.506; p = 0.014), extracorporeal correction of homeostasis increased by 1.8 times (OR 1.821; p = 0.034), and diastasis of the wound edges increased by 1.3 times (OR 1.266; p = 0.005). It is important that, when adjusting for gender and age, the effect of GMD on the described complications remained significant. Conclusions: Active preoperative detection established an extremely high prevalence of GMD in patients with multivessel coronary artery disease (59.5%). T2DM and prediabetes are significant predictors of postoperative complications of coronary artery bypass grafting. Full article
(This article belongs to the Special Issue New Insights into Diabetes and Cardiovascular Diseases)
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