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Dear Colleagues，

Bipolar disorder is a disabling illness due to its early onset, severity and chronicity. Its global prevalence in 2019 was estimated at nearly 40 million patients, and the disorder poses a risk for patients’ well-being, not only through direct negative outcomes but also through indirect effects associated with poverty, suicide and co-morbid health issues. Furthermore, bipolar disorder places a considerable burden on families and significant others. These facts point to the significance of appropriate therapeutic interventions for bipolar disorder. To a large extent, the first onset of the disorder will require hospitalization, with a high chance for subsequent re-entries to a clinical environment. The aim of this Special Issue is to highlight the difficulties in the clinical handling of bipolar disease and any new treatment solutions.

Dr. Georgios Floros
Guest Editor

Manuscript Submission Information

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Keywords

bipolar disorder
manic episode
mixed episode
patient adherence
psychosocial burden
harm reduction

Published Papers (2 papers)

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Review

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13 pages, 418 KiB

Open AccessReview

Bipolar Disorder and Gaming Disorder—Compatible or Incompatible Diagnoses?

by Georgios Floros and Ioanna Mylona

J. Clin. Med. 2023, 12(19), 6251; https://doi.org/10.3390/jcm12196251 - 28 Sep 2023

Viewed by 925

Abstract

Gaming Disorder (GD) is one of the latest additions in the psychiatric taxonomy, following its official inclusion in the latest revision of the International Classification of Diseases (ICD-11). This narrative review examines the rationale of an exclusion criterion for the diagnosis of GD, that of disordered gaming being limited exclusively during an episode of elevated mood in bipolar disorder. The history of the formulation of diagnostic criteria for the disorder and all relevant published studies are examined critically, and conclusions are drawn as to the potential validity and usability of the exclusion criterion. Suggestions are offered for future research to elucidate not only the relevance of the exclusion criterion but also the differential diagnosis of GD with pathological gambling (PG). Full article

(This article belongs to the Special Issue Advances in Clinical Management of Bipolar Disorder: 2nd Edition)

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Other

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17 pages, 1299 KiB

Open AccessSystematic Review

Antimanic Efficacy, Tolerability, and Acceptability of Clonazepam: A Systematic Review and Meta-Analysis

by Andreas S. Lappas, Bartosz Helfer, Katarzyna Henke-Ciążyńska, Myrto T. Samara and Nikos Christodoulou

J. Clin. Med. 2023, 12(18), 5801; https://doi.org/10.3390/jcm12185801 - 06 Sep 2023

Cited by 1 | Viewed by 1794

Abstract

(1) Background: The use of benzodiazepines for the treatment of acute mania remains prevalent. This systematic review and meta-analysis provides an updated assessment of Clonazepam’s antimanic efficacy, tolerability, and acceptability. (2) Methods: A systematic search of multiple databases and clinical trial registries was conducted, aiming to identify any controlled studies of Clonazepam vs. placebo or any other pharmacotherapy for the treatment of acute mania. Pairwise meta-analytic evaluations were performed. (3) Results: Six studies were included with a total number of 192 participants, all of which were randomized controlled trials. Clonazepam may be superior to a placebo in the acute phase of treatment and no different to Lithium and Haloperidol in terms of efficacy, both acutely and in the medium to long term. Clonazepam may be an acceptable and well-tolerated treatment for acute mania, especially when used as an augmentation strategy. Comparisons were underpowered, with minimal sample sizes and only one study per comparison in many cases, thus limiting the generalizability of our findings and hindering firm clinical conclusions. (4) Conclusions: Given the prevalence of benzodiazepine use in current practice, more and larger studies are urgently needed. Full article

(This article belongs to the Special Issue Advances in Clinical Management of Bipolar Disorder: 2nd Edition)

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