Advances in Breast Reconstruction: New Technologies Improving Clinical Outcomes

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine".

Deadline for manuscript submissions: 18 September 2025 | Viewed by 328

Special Issue Editor


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Guest Editor
Division of Plastic and Reconstructive Surgery, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy
Interests: plastic and reconstructive surgery; microsurgery; breast surgery; wound healing; cosmetic surgery; hand surgery

Special Issue Information

Dear Colleagues,

Breast reconstruction is a critical component of post-mastectomy care and congenital breast malformation correction. Recent advancements in surgical techniques, biomaterials, fat grafting, and artificial intelligence (AI) have significantly enhanced reconstructive outcomes, improving both functional and esthetic results. This Special Issue will highlight the latest clinical applications of emerging technologies in breast reconstruction, providing a platform for research that directly impacts patient care.

Acellular dermal matrices (ADMs) have improved implant-based reconstruction by enhancing tissue integration and reducing complications. Next-generation prostheses and implant designs offer greater biocompatibility and durability, leading to better long-term outcomes. The integration of AI into surgical planning and intraoperative decision-making is revolutionizing precision in reconstructive procedures, reducing complications, and allowing personalized treatments. Additionally, innovations in corrective surgery for congenital and acquired breast deformities, including Poland syndrome and tuberous breast, are providing new surgical strategies to optimize patient-centered care.

Furthermore, lipofilling has gained increased importance in both primary and secondary breast reconstruction. Advances in fat grafting techniques, stem cell-enriched fat transfer, and the combination of lipofilling with other reconstructive approaches have expanded its indications, allowing for enhanced volume restoration, improved contouring, and better soft tissue quality. Currently, researchers are investigating the role of lipofilling in radiotherapy-damaged tissues, its regenerative potential, and the long-term effects on oncological safety.

For this Special Issue, we welcome original research and systematic reviews focusing on clinically relevant innovations in breast reconstruction, including lipofilling advancements, biomaterial innovations, AI-assisted techniques, and novel corrective procedures. We encourage submissions that explore the impact of new surgical approaches on patient outcomes, complication rates, and long-term safety. By gathering the latest evidence-based findings, we aim to advance the field of reconstructive surgery and improve clinical practice in breast reconstruction.

Dr. Luigi Antonio Valdatta
Guest Editor

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Keywords

  • breast reconstruction
  • acellular dermal matrix (ADM)
  • artificial intelligence in surgery
  • advanced prostheses
  • breast malformation correction
  • 3D printing in reconstruction
  • robotic-assisted breast surgery
  • regenerative surgery

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Published Papers (1 paper)

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Research

16 pages, 2528 KiB  
Article
Long-Term Shape and Volume Retention of Acellular Dermal Matrix in Oncoplastic Breast-Conserving Surgery: A 2-Year Retrospective Study
by Hyung-suk Yi, Jeong-jin Park, Jin-hyung Park, Hong-Il Kim, Jong-Hyouk Yun, Sung-ui Jung, Jin-hyuk Choi, Ku-sang Kim and Yoon-soo Kim
J. Clin. Med. 2025, 14(9), 3002; https://doi.org/10.3390/jcm14093002 - 26 Apr 2025
Viewed by 241
Abstract
Background/Objectives: To quantitatively assess the long-term volume stability of acellular dermal matrix (ADM) in oncoplastic breast-conserving surgery (OBCS) and analyze surgical and aesthetic outcomes. Methods: This retrospective study examined 172 breast cancer patients who underwent OBCS with immediate ADM-based volume replacement [...] Read more.
Background/Objectives: To quantitatively assess the long-term volume stability of acellular dermal matrix (ADM) in oncoplastic breast-conserving surgery (OBCS) and analyze surgical and aesthetic outcomes. Methods: This retrospective study examined 172 breast cancer patients who underwent OBCS with immediate ADM-based volume replacement (2020–2022). Patients received either diced ADM with sheet ADM (n = 102) or diced ADM with paste ADM (n = 70). The ADM volume was evaluated using MRI at 6, 12, and 24 months postoperatively. Results: Long-term volume stability was achieved in both groups with minimal volume reduction (4.3–4.5%) at 24 months (p < 0.001). Early surgical complications included hematoma (4.1%), seroma (2.3%), and wound issues (1.2%), with no infections or ADM non-incorporation. Contour irregularities occurred in 16.3% of cases. Radiotherapy (87% of patients) did not significantly impact ADM volume retention. Conclusions: ADM provides predictable, durable volume replacement in OBCS, with excellent volume stability even with radiotherapy. This quantitative assessment of ADM volume retention over two years supports ADM as a reliable option for breast-conserving surgery, potentially expanding treatment options for patients with unfavorable tumor-to-breast volume ratios. Full article
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